National University Hospital, Singapore: Breast Neoplasms trials

The registry lists 46 Breast Neoplasms studies with National University Hospital, Singapore as lead sponsor. 11 are open to participants now and 1 have results posted.

Phase 1 11Phase 2 20Phase 3 1No phase 23(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Community Study to Increase Mammogram Screening Among Overdue WomenEnrolling by invitationNCT07832396Not applicable
• Mepitel Film BreastRecruitingNCT07729423
• Tislelizumab in Combination With Bevacizumab and Capecitabine in Advanced Solid Tumors With Evaluation in Immunotherapy-Resistant and Central Nervous System DiseaseNot yet recruitingNCT07681297Phase 1/2
• Trial to Evaluate the Impact of Various Pragmatic Interventions to Increase Mammography Uptake Among Defaulted Repeat Screeners in SingaporeEnrolling by invitationNCT07651345Not applicable
• Trial to Evaluate the Impact of Various Behavioural Interventions to Increase Mammography Uptake Among Singaporean WomenEnrolling by invitationNCT07283107Not applicable
• Pembrolizumab and ADG106 in Advanced Solid Cancers and Triple Negative Breast CancerRecruitingNCT05491083Phase 1/2
• Optimizing and Personalising Azacitidine Combination Therapy for Treating Solid Tumours QPOP and CURATE.AIRecruitingNCT05381038Phase 1/2
• Lenvatinib+Letrozole Versus Fulvestrant in Metastatic ER+/HER2- Breast Cancer, Post Progression on Al + CDK4/6 InhibitorRecruitingNCT05181033Phase 2
• Quadratic Phenotypic Optimisation Platform (QPOP) Utilisation to Enhance Selection of Patient Therapy Through Patient Derived Organoids in Breast CancerRecruitingNCT05177432Phase 1
• Selinexor & Talazoparib in Advanced Refractory Solid Tumors; Advanced/Metastatic Triple Negative Breast Cancer (START)RecruitingNCT05035745Phase 1/2
• 12-week Exercise Intervention Program Versus Observation in Early Stage Breast Cancer Patients on the Impact on Mental Health, Quality of Life and Immune MarkersRecruitingNCT03518957Phase 3
• Trial to Evaluate the Impact of Various Interventions to Increase the Uptake of Surveillance Mammography in Eligible Women in SingaporeCompletedNCT06733155Not applicableResults posted
• Pulsed Electromagnetic Fields (PEMFs) - A Highly Selective Breast CAncer Treatment pLatform (PASCAL)CompletedNCT06332508Phase 1
• Multidisciplinary Rehabilitation Programme for Breast CancerCompletedNCT05306808Not applicable
• A Single Arm, Phase Ib/II Trial of Single Agent Pacritinib in Patients With 1q21.3 Amplified Solid Tumors Enriching for Interleukin-1 Receptor-associated Kinase 1 Pathway Activation (PAIR)Active, not recruitingNCT04520269Phase 1/2
• Phase II Study of FTD/TPI (Lonsurf) in Metastatic Breast Cancers With or Without Prior Exposure to Fluoropyrimidines (LONBRECA)Active, not recruitingNCT04280536Phase 1/2
• Metformin and Simvastatin in Addition to FulvestrantStatus unknownNCT03192293Phase 2
• Phase II Study of Single Agent LenvatinibStatus unknownNCT03168074Phase 2
• Dose-dense Doxorubicin/Cyclophosphamide With Intermittent Low-dose Sunitinib in Breast Cancer PatientsStatus unknownNCT02790580Phase 2
• Neoadjuvant Lenvatinib Combined With Letrozole in Hormone Receptor Positive Breast CancerActive, not recruitingNCT02562118Phase 1/2
• Dose-confirmation Study of ASLAN001 Combined With Weekly Paclitaxel and Carboplatin in Advanced Solid Tumours, Followed by a Study in Patients With Stage I-III HER2 Positive Breast CancerStatus unknownNCT02396108Phase 1/2
• A Prospective Study on Effect of Systemic Adjuvant Therapy on Cognitive and Brain Function of Breast Cancer PatientsStatus unknownNCT02078531
• Correlation Between Genetic Variants and Long-term Cardiac Effects Induced by Doxorubicin in Breast Cancer PatientsStatus unknownNCT02078388
• Using National University Cancer Institute of Singapore (NCIS) Registry to Measure Time Trends in Quality of Care for Breast Cancer Patients in a National Cancer CentreStatus unknownNCT01866631
• Study of Circulating and Tumor Biomarkers in Breast Cancer PatientsStatus unknownNCT01866202
• Prospective Study of UDP-gluconoryltransferase 2B17 Genotype as a Predictive Marker of Exemestane PK and PDStatus unknownNCT01655004Not applicable
• Uncovering Potential Breast Cancer Biomarkers Amp; Possible Drug Targets Using Advanced Quantitative Mass SpectrometryStatus unknownNCT01619514
• Knowledge and Attitudes of Patients and Healthcare Professionals on a Spectrum of Genetic Tests Relevant to Breast Cancer PatientsStatus unknownNCT01619306
• A Prospective Study to Evaluate the Effect of Systemic Adjuvant Therapy on the Cognitive Function of Breast Cancer PatientsStatus unknownNCT01596439
• Study of Preoperative Weekly Paclitaxel and Carboplatin With Lapatinib (Tykerb®) in Patients With ErbB2-Positive Stage I-III Breast CancerStatus unknownNCT01309607Phase 2
• Analysis of Prognostic and Predictive Genomic Signatures Using Archival Paraffin-embedded Tumor Specimens in Breast CancerStatus unknownNCT01247480
• Analysis of Prognostic and Predictive Genomic Signatures Using Archival Paraffin-embedded Breast Tumor - a Pilot StudyStatus unknownNCT01247467
• Breast Cancer Registry - National University Health System, SingaporeStatus unknownNCT01247441
• Comparative Genomic and Genetic Analysis of Paired Primary Breast - Metastatic Tumor Specimens Using High-throughput PlatformsStatus unknownNCT01227733
• Randomized Study of Doxorubicin and Cyclophosphamide With or Without Intermittent Sunitinib in the First-line Treatment of Locally Advanced or Metastatic Breast Cancer Patients With Measurable Primary Breast TumorStatus unknownNCT01176799Phase 2
• Development of Predictive Biomarkers and Novel Approached to Therapy in Breast CancerStatus unknownNCT01051492
• Biomarker Study of Breast TumorsStatus unknownNCT00941408
• Phase II Study of Simvastatin in Primary Breast Cancer; Test of Its Potential Selectivity on Basal Subtype Breast CancerStatus unknownNCT00807950Phase 2
• Tamoxifen Pharmacokinetics and CYP2D6 Polymorphisms in Asian Women With Hormone Receptor Positive Breast CancerCompletedNCT00717015
• Evaluation of Brain Function Before and After Standard Chemotherapy for Early Breast CancerCompletedNCT00713141
• Chemotherapy on Methylation Patterns in Breast Tumor Tissue Correlating With Clinical Response and OutcomesStatus unknownNCT00698477
• Validate Gene Expression and Proteomic Signatures Predictive of Treatment for Response for Breast Cancer PatientStatus unknownNCT00669773Phase 2
• Clinical Trial of SAHA in Patients With Breast CancerStatus unknownNCT00416130Phase 1/2
• Docetaxel Combined With Ketoconazole in Treatment of Breast CancerCompletedNCT00212095Phase 2
• Gene Expression Profiles in Predicting Chemotherapy Response in Breast CancerCompletedNCT00212082Phase 2
• Serum Proteomics to Predict Gemcitabine Sensitivity in Breast CancerCompletedNCT00212069Phase 2