National Institute of Allergy and Infectious Diseases (NIAID): Hypersensitivity trials

The registry lists 39 Hypersensitivity studies with National Institute of Allergy and Infectious Diseases (NIAID) as lead sponsor. 7 are open to participants now and 14 have results posted.

Early Phase 1 4Phase 1 6Phase 2 14No phase 17(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Beginning to Assess an Appropriate CONtrol for Oral Food Challenges in Alpha-Gal Syndrome (CoFAR-13) - BeACON4AGRecruitingNCT07611435Phase 2
• LYmph Node eXamination in Cat Allergen ImmunotherapyRecruitingNCT07447869Early Phase 1
• Study of Oral Food Challenge Biomarkers (SAFER)RecruitingNCT07279467
• Microbiome and Atopy in MaliRecruitingNCT07051902
• A Biorepository of Multiple Allergic Diseases (MADREP) With Longitudinal Follow-UpRecruitingNCT06732414
• Registry of Asthma Characterization and Recruitment 3 (RACR3)RecruitingNCT05272241
• Activation and Function of Eosinophils in Conditions With Blood or Tissue EosinophiliaRecruitingNCT00001406
• The Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Allergic Reaction to an Initial DoseCompletedNCT04977479Phase 2Results posted
• COVID19 SARS Vaccinations: Systemic Allergic Reactions to SARS-CoV-2 VaccinationsCompletedNCT04761822Phase 2Results posted
• Follow up of LEAP Participants and Their FamiliesCompletedNCT03546413Results posted
• Cockroach Nasal Allergen Challenge PilotCompletedNCT02710136Phase 1Results posted
• Anti-TSLP (AMG 157) Plus Antigen-Specific Immunotherapy for Induction of Tolerance in Individuals With Cat AllergyCompletedNCT02237196Phase 1/2Results posted
• Peanut Epicutaneous Phase II Immunotherapy Clinical TrialCompletedNCT01904604Phase 2Results posted
• Peanut Oral Immunotherapy in ChildrenCompletedNCT01867671Phase 2Results posted
• Persistence of Oral Tolerance to PeanutCompletedNCT01366846Phase 2Results posted
• Safety Evaluation of an Experimental Treatment, Intradermal Human Fcγ1-Fel d1 Fusion Protein (GFD), for Cat AllergyTerminatedNCT01292070Early Phase 1Results posted
• Study of Milk Allergy and Tolerance in ChildrenCompletedNCT00778258Phase 2Results posted
• A Randomized, Double-Blind Placebo-Controlled Peanut Sublingual Immunotherapy TrialCompletedNCT00580606Phase 1/2Results posted
• Oral Immunotherapy for Childhood Egg AllergyCompletedNCT00461097Phase 2Results posted
• Sublingual Cockroach Safety in Adults With Cockroach Allergy & Perennial Allergic Rhinitis With or Without AsthmaCompletedNCT00434421Phase 1Results posted
• Promoting Tolerance to Peanut in High-Risk ChildrenCompletedNCT00329784Phase 2Results posted
• A Randomized Prospective Clinical Trial of Fel d 1 Peptide ImmunotherapyCompletedNCT02311413Phase 2
• Impact of Vaccination on Th2 Immunity in InfancyTerminatedNCT02213341
• Cat Pilot Study - Environmental Exposure Chamber (EEC) vs. Nasal Allergen Challenge (NAC)CompletedNCT02163122Early Phase 1
• Immunopathogenesis of Food Allergy and Eosinophilic Gastrointestinal DisordersTerminatedNCT01212016
• Screening Protocol for Genetic Diseases of Allergic InflammationCompletedNCT00852943
• Normal Blood, Bone Marrow and Buccal Mucosa ProtocolCompletedNCT00806364
• An Interventional Study of Milk AllergyCompletedNCT00578656Early Phase 1
• Evaluation and Long-Term Follow-Up of Patients With Allergic and Inflammatory DisordersTerminatedNCT00557895
• An Observational Study of Childhood Food AllergyCompletedNCT00356174
• Urban Environmental Factors and Childhood AsthmaCompletedNCT00114881
• Clinical and Immunological Evaluation of Children With AllergiesCompletedNCT00102570
• Omalizumab (Xolair) and Allergy Shots For the Treatment of Seasonal AllergiesCompletedNCT00078195Phase 2
• Mechanisms of Allergen ImmunotherapyCompletedNCT00001910
• Phase II Efficacy Study of Aerosolized Recombinant Human IL-4 Receptor in AsthmaCompletedNCT00001909Phase 2
• T Cell Cytokine Changes During IL-4 Receptor Treatment for AsthmaCompletedNCT00001908
• Assessment of Lung Inflammation in Patients With Atopic Asthma Using Positron Emission TomographyCompletedNCT00001759
• A Phase I/II Study of Delayed-Type Hypersensitivity (DTH) Reactions to Intradermal HIV Envelope AntigenCompletedNCT00000782Phase 1
• A Phase I/II Dose Escalation Study of Intradermal gp160 to Evaluate Safety, Delayed Type Hypersensitivity (Skin Test) Responses and Immunogenicity in Asymptomatic HIV Seropositive Patients With More Than 400 CD4+ CellsCompletedNCT00000667Phase 1