National Heart, Lung, and Blood Institute (NHLBI): Graft vs Host Disease trials

The registry lists 24 Graft vs Host Disease studies with National Heart, Lung, and Blood Institute (NHLBI) as lead sponsor. 2 are open to participants now and 12 have results posted.

Phase 1 5Phase 2 15Phase 3 2No phase 5(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Long-term Evaluation and Follow-up Care of Patients Treated With Stem Cell TransplantsRecruitingNCT00106925
• Improved Methods of Cell Selection for Bone Marrow Transplant AlternativesRecruitingNCT00001529
• Using Fostamatinib to Treat Post-Hematopoietic Stem Cell Transplant Immune-mediated CytopeniasTerminatedNCT05502783Phase 2Results posted
• Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell DiseaseActive, not recruitingNCT03077542Phase 1/2Results posted
• Early Treatment of Acute Graft Versus Host Disease With Bone Marrow-Derived Mesenchymal Stem Cells and CorticosteroidsTerminatedNCT02379442Phase 1/2Results posted
• Calcineurin Inhibitor-Free Interventions BMT CTN 1301 for Prevention of Graft-versus-Host Disease (BMT CTN 1301)CompletedNCT02345850Phase 3Results posted
• Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)CompletedNCT02208037Phase 2Results posted
• Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant FailureActive, not recruitingNCT02105766Phase 2Results posted
• Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans SyndromeCompletedNCT01287078Phase 2Results posted
• Extension Study (Extended Access) of Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis ObliteransCompletedNCT01273207Phase 2Results posted
• Haploidentical PBMC Transplant for Severe Congenital AnemiasActive, not recruitingNCT00977691Phase 1/2Results posted
• Dexamethasone to Prevent Oral Chronic Graft-versus-Host DiseaseCompletedNCT00391170Phase 2Results posted
• Treatment for Acute Graft-Versus-Host Disease (BMT CTN 0302)CompletedNCT00224874Phase 2Results posted
• Selective T-Cell Depletion to Reduce GVHD (Patients) Receiving Stem Cell Tx to Treat Leukemia, Lymphoma or MDSCompletedNCT00025662Phase 2Results posted
• Extension Study (Extended Access) of Syk-inhibition Using Fostamatinib to Treat Posttransplant Immune-mediated CytopeniasWithdrawnNCT05509582Phase 2
• Bone Marrow Stromal Cell Infusions for Stem Cell Transplant ComplicationsCompletedNCT01633229Phase 1
• Blood and Marrow Transplant Clinical Research NetworkCompletedNCT00023530Not applicable
• The Role of Cyclosporine in Blood Cell Transplants With T-Cell Add-Back for Blood CancersCompletedNCT00001873Phase 2
• Cell Selection for Bone Marrow Transplants to Prevent Graft-Versus-Host-DiseaseCompletedNCT00001872
• HLA-Mismatched Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematological MalignanciesCompletedNCT00001748Phase 1
• Immunosuppressive Preparation Followed by Blood Cell Transplant for the Treatment of Blood Cancers in Older AdultsCompletedNCT00001637Phase 2
• Bone Marrow Transplant Studies for Safe and Effective Treatment of LeukemiaCompletedNCT00001623Not applicable
• Modified Bone Marrow Stem Cell Transplantation for Chronic Myelogenous LeukemiaCompletedNCT00001144Phase 2
• T-Cell Depletion in Unrelated Donor Marrow TransplantationCompletedNCT00000591Phase 3