Mayo Clinic: Irritable Bowel Syndrome trials

The registry lists 26 Irritable Bowel Syndrome studies with Mayo Clinic as lead sponsor. 3 are open to participants now and 12 have results posted.

Early Phase 1 1Phase 1 3Phase 2 10Phase 3 1Phase 4 2No phase 11(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Novel Pilot Study to Treat Symptoms of IBS With Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a NeuromodulatorRecruitingNCT06684470Early Phase 1
• Enabling Microbiomics- Driven Personalized NutritionEnrolling by invitationNCT06657001
• Mucosal and Microbiota Changes During Acute CampylobacteriosisRecruitingNCT03223077
• Comparison of Rimegepant and Placebo for Pain in IBSCompletedNCT06221111Phase 2Results posted
• Trial to Understand Efficacy of Colesevelam in Diarrhea Predominant IBS Patients With Bile Acid MalabsorptionCompletedNCT03270085Phase 2Results posted
• Biomarkers for Intestinal Permeability in Patients With ConstipationCompletedNCT02246647Results posted
• Effect of Ranolazine on Gastrointestinal Motor Function and Pain in Patients With IBS-DTerminatedNCT02239926Phase 2/3Results posted
• Ability of Mayo Clinic High-performance Liquid Chromatography (HPLC) Method to Measure Fecal Bile AcidsCompletedNCT02111603Phase 4Results posted
• Pregabalin on Colonic Motor and Sensory Function in Constipation Predominant Irritable Bowel SyndromeCompletedNCT01331213Phase 4Results posted
• Effect of Cannabinoid Agonist on Gastrointestinal and Colonic Motor Functions in Patients With Irritable Bowel Syndrome (IBS)CompletedNCT01253408Phase 2Results posted
• Effects of ROSE-010 on GI Transit in Constipation Predominant Irritable Bowel Syndrome (C-IBS) PatientsCompletedNCT01056107Phase 1/2Results posted
• A Placebo-Controlled Trial of Pregabalin (Lyrica) for Irritable Bowel SyndromeCompletedNCT00977197Phase 2Results posted
• Cheno Effect on Transit in Health and IBS-CCompletedNCT00912301Phase 2Results posted
• Does Welchol (Colesevelam Hydrochloride) Improve Colonic Transit in Diarrhea-predominant Irritable Bowel Syndrome (D-IBS)?CompletedNCT00911612Phase 2Results posted
• A Placebo-Controlled Trial of St. John's Wort for Irritable Bowel SyndromeCompletedNCT00587860Phase 2Results posted
• A Study of Varenicline in the Treatment of Visceral SensationCompletedNCT06854406Phase 1
• A Study of Hemp Hull WFI for IBS DiarrheaCompletedNCT06028035Not applicable
• Implementing a Low FODMAP Diet in Irritable Bowel Syndrome PatientsCompletedNCT03948854Not applicable
• Epidemiology and Pathophysiology of Post-Infectious Functional GI DisordersCompletedNCT03266068
• Analyzing IBS to Identify Biomarkers and Microbiome SignaturesCompletedNCT02419963Not applicable
• Gut Permeability, Sensitivity and SymptomatologyCompletedNCT02358564Not applicable
• Developing Novel Microbiota-Targeted Therapies for Irritable Bowel SyndromeCompletedNCT02249169
• Serum-Derived Bovine Immunoglobulin /Protein Isolate (SBI) 5.0 g Bid on Nutritional Status in Subjects With IBS-DCompletedNCT02163213Not applicable
• Gluten Intolerance in Patients With Diarrhea Predominant Irritable Bowel SyndromeCompletedNCT01094041Not applicable
• Effect of Asimadoline, a Member of a New Medication Class, on Acute Attacks of Pain in Irritable Bowel SyndromeCompletedNCT00955994Phase 2
• Intestinal Microecology in Chronic ConstipationCompletedNCT00934479Phase 1