Massachusetts General Hospital: Depressive Disorder trials

The registry lists 110 Depressive Disorder studies with Massachusetts General Hospital as lead sponsor. 3 are open to participants now and 58 have results posted.

Phase 1 1Phase 2 15Phase 3 7Phase 4 22No phase 66(a study in two phases counts in both)

Studies

Page 1 of 2. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via InfliximabRecruitingNCT06136546Phase 2
• Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental IllnessRecruitingNCT05962879Not applicable
• Sensor-based Characterization of DepressionRecruitingNCT04370002
• Bridging the Gap From Postpartum to Primary CareCompletedNCT05543265Not applicableResults posted
• Fluoxetine Treatment of Depression in Down SyndromeCompletedNCT05458479Phase 4Results posted
• Therapist-Guided Smartphone-Delivered CBT for MDDCompletedNCT05386329Not applicableResults posted
• Vagus Nerve Stimulation: Integration of Behavior and Cardiac ModulationCompletedNCT04467164Not applicableResults posted
• Examining Validity and Reliability of the Shared Decision Making Process Survey in Adults With DepressionCompletedNCT04343534Results posted
• PEERS Using Peer Mentors to Deliver Depression CareCompletedNCT04319094Not applicableResults posted
• MBCT Delivered Via Group Videoconferencing for ACS Patients With Elevated Depression SymptomsCompletedNCT03878160Not applicableResults posted
• Preventing Depressive Relapse in Pregnant Women With Recurrent DepressionCompletedNCT03623620Not applicableResults posted
• A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)CompletedNCT03149991Phase 4Results posted
• Support for Perinatal Adherence and DepressionCompletedNCT03069417Not applicableResults posted
• Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of VortioxetineTerminatedNCT02969876Phase 4Results posted
• Transcranial Laser Therapy, Continuous and Pulsed Light, for Major Depressive Disorder (ELATED-3)CompletedNCT02959307Not applicableResults posted
• Augmentation of Treatment-Resistant Depression With An Analog of the Neuroactive Steroid AllopregnanoloneCompletedNCT02900092Not applicableResults posted
• Integrated Smoking Cessation Treatment for Smokers With Serious Mental IllnessCompletedNCT02845440Not applicableResults posted
• EnBrace HR for Depression Treatment and Prevention in Women Trying to Conceive and Early PregnancyCompletedNCT02676882Not applicableResults posted
• Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Personalized ApproachCompletedNCT02553915Phase 2/3Results posted
• Ketamine for Depression: An MRI StudyCompletedNCT02544607Phase 4Results posted
• Preventing Postpartum Depression With Intranasal OxytocinCompletedNCT02505984Phase 2Results posted
• Vortioxetine for Menopausal DepressionCompletedNCT02234362Phase 4Results posted
• Investigation of Brain Network Dynamics in DepressionCompletedNCT01931995Not applicableResults posted
• Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)CompletedNCT01920555Phase 2Results posted
• Proof-of-Concept Trial of CERC-501 Augmentation of Antidepressant Therapy in Treatment-Resistant DepressionTerminatedNCT01913535Phase 2Results posted
• Low-Dose Naltrexone (LDN) for Depression Relapse and RecurrenceCompletedNCT01874951Phase 2Results posted
• Neurobiological Bases of Placebo Response in Major Depressive DisorderTerminatedNCT01787240Phase 4Results posted
• Ketamine Versus Placebo for Treatment Resistant Major Depressive DisorderCompletedNCT01667926Not applicableResults posted
• Trial of Low Field Magnetic Stimulation Augmentation of Antidepressant Therapy in Treatment-Resistant DepressionCompletedNCT01654796Not applicableResults posted
• Ketamine Infusion for Treatment-resistant Major Depressive DisorderCompletedNCT01582945Not applicableResults posted
• Stimulant Enhancement of Well-Being Therapy for DepressionTerminatedNCT01478113Not applicableResults posted
• Study of Probiotic GanedenBC30 for Irritable Bowel Syndrome and Major Depressive DisorderTerminatedNCT01337609Phase 4Results posted
• Efficacy and Safety of Cranial Electrical Stimulation (CES) for Major Depressive Disorder (MDD)CompletedNCT01325532Not applicableResults posted
• N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major DepressionTerminatedNCT01260649Phase 4Results posted
• A Collaborative Care Program to Improve Treatment of Depression and Anxiety Disorders in Cardiac PatientsCompletedNCT01201967Phase 4Results posted
• Duloxetine for Menopausal DepressionCompletedNCT01117857Phase 4Results posted
• Pilot Study of Open-label Placebo to Treat Major Depressive DisorderCompletedNCT01103271Phase 2Results posted
• Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic SymptomsTerminatedNCT00955474Phase 4Results posted
• A Collaborative Care Program to Improve Depression Treatment in Cardiac PatientsCompletedNCT00847132Not applicableResults posted
• Escitalopram (Lexapro) for the Treatment of Postpartum DepressionCompletedNCT00833469Phase 4Results posted
• Omega-3 for Peri- and Postmenopausal DepressionCompletedNCT00825994Not applicableResults posted
• Quantitative Electroencephalogram (QEEG) Predictors of Response to Psychotherapy Versus Antidepressant Treatment in DepressionCompletedNCT00824044Phase 4Results posted
• Open Label Extension Assessing the Tolerability of BCI-024 in Combination With BCI-049 in Patients With Major Depressive Disorder (MDD)CompletedNCT00731653Phase 2Results posted
• Efficacy and Safety Study of a Combination Product [Drug:BCI-024 (Buspirone) and Drug:BCI-049 (Melatonin)] to Treat Major Depressive Disorder (MDD)CompletedNCT00705003Phase 2Results posted
• A Double-Blind, Placebo-Controlled Study of Aripiprazole Adjunctive to Antidepressant TherapyCompletedNCT00683852Phase 3Results posted
• Effects of Testosterone in Women With DepressionCompletedNCT00676676Not applicableResults posted
• Ziprasidone Augmentation of SSRIs for Patients With Major Depressive Disorder (MDD) That do Not Sufficiently Respond to Treatment With SSRIsCompletedNCT00633399Phase 2Results posted
• The Oral Contraceptive Pill for Premenstrual Worsening of DepressionCompletedNCT00633360Not applicableResults posted
• The Use of Galantamine HBr (Reminyl) in Electroconvulsive Therapy: Impact on Mood and Cognitive FunctioningCompletedNCT00566735Phase 3Results posted
• The Combination of Aripiprazole and Antidepressants in Psychotic Major DepressionCompletedNCT00556140Phase 3Results posted
• A 12-Week, Placebo Controlled Trial of Ziprasidone as Monotherapy for Major Depressive DisorderCompletedNCT00555997Phase 2Results posted
• Investigating the Effectiveness of Telepsychiatry for Treating Major Depression in a Chinese American Nursing HomeCompletedNCT00505518Not applicableResults posted
• Brain GABA Levels and Treatment Response in Major Depressive DisorderCompletedNCT00464711Phase 4Results posted
• Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and AlcoholismCompletedNCT00452543Phase 4Results posted
• Escitalopram in Treating Depression in Patients With Advanced Lung or Gastrointestinal CancerTerminatedNCT00387348Phase 3Results posted
• Safety and Effectiveness of Omega 3-Fatty Acids, EPA Versus DHA, for the Treatment of Major DepressionCompletedNCT00361374Phase 3Results posted
• Biological Markers of Response to Treatment in Major Depressive DisorderCompletedNCT00361218Phase 3Results posted
• Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1CompletedNCT00218634Not applicableResults posted
• Brain Energy Metabolism in Individuals With Major Depressive Disorder Receiving EscitalopramCompletedNCT00183677Phase 4Results posted
• Optimizing the Effectiveness of Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment-Resistant DepressionCompletedNCT00093847Phase 2Results posted
• Drug Therapy to Treat Minor DepressionCompletedNCT00048815Not applicableResults posted
• The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDDWithdrawnNCT05381974Phase 2
• Peripheral Neuroimmune Mechanisms of HyperthermiaStatus unknownNCT05366270Not applicable
• Effects of Respiratory-Gated Transcutaneous Vagal Nerve Stimulation in Major Depression (Phase 1)CompletedNCT04607226Not applicable
• Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD)WithdrawnNCT04594616Not applicable
• Transcranial Photobiomodulation for the Treatment of Pediatric DepressionWithdrawnNCT04579185Not applicable
• Mechanism of Action of Electroconvulsive TherapyCompletedNCT04059952
• Preventing Depression and Anxiety: A Cystic Fibrosis-Specific Cognitive Behavioral Therapy InterventionCompletedNCT03992027Not applicable
• Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD), WithdrawnWithdrawnNCT03769350Not applicable
• Comparative Effectiveness of Pharmacogenomics for Treatment of DepressionCompletedNCT03749629Not applicable
• The Role of Cognitive Control in the Transdiagnostic Conceptualization of "Intrusive Thoughts"CompletedNCT03414619Not applicable
• Neurocognitive Features of Patients With Treatment-Resistant DepressionCompletedNCT03134066
• Pragmatic Collaborative Care for Cardiac Inpatients With Depression or AnxietyCompletedNCT03118752Not applicable
• Preconception and Pregnancy Obesity Treatment and Prevention Among Women With a History of DepressionCompletedNCT03053323Not applicable
• Translational Investigation of Gestational Environment on Neurobehavioral Function in ChildrenCompletedNCT02715778
• Noninvasive Physiologic Sensors to Assess DepressionCompletedNCT02568865
• Mood Patient Powered Research Network (MoodNetwork)CompletedNCT02453438
• Intranasal Ketamine for Late-Life Depression and Suicidal IdeationWithdrawnNCT02295787Phase 4
• Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) StudyCompletedNCT02253225
• Effects of Mindfulness-based Cognitive Therapy on Brain Mechanisms in DepressionCompletedNCT02200341Not applicable
• The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar DepressivesWithdrawnNCT02028026Phase 4
• Trial of a Positive Psychology Intervention in Major Depressive DisorderCompletedNCT02004145Not applicable
• Retrospective Medical Record Review of Mind Body Depression Group ParticipantsCompletedNCT01909921
• Using SMART Experimental Design to Personalize Treatment for Child DepressionCompletedNCT01880814Not applicable
• Effectiveness and Acceptability of MoodGYM in Treating Depressive Symptoms in Chinese AmericansCompletedNCT01851967Not applicable
• Symptom Tracking in Assisted Reproductive TechnologiesCompletedNCT01746797
• Neuroimaging Studies of the Treatment of Bipolar Depression With CitalopramCompletedNCT01639482
• Tai Chi Intervention for Chinese Americans With DepressionCompletedNCT01619631Not applicable
• Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive DisorderWithdrawnNCT01613820Not applicable
• Complex Dynamic Systems in Mood DisordersCompletedNCT01583569
• Potential Use Of Brain Network Activation Analysis to Diagnose Major DepressionTerminatedNCT01579942
• Cognitive Behavioral Therapy (CBT) for Adherence and Depression in Type 1 DiabetesCompletedNCT01527981Phase 2
• ON/OFF Stimulation and Impulsivity in Patients With Deep Brain StimulatorsWithdrawnNCT01506206
• Mindfulness Based Cognitive Therapy for Chronic Pain and Comorbid Unipolar DepressionStatus unknownNCT01473615Not applicable
• Cognitive-Behavioral Therapy (CBT) in Women Discontinuing Antidepressant for PregnancyCompletedNCT01453114Not applicable
• Internet-Based Depression Screening for College StudentsCompletedNCT01326793Not applicable
• Risks for Insulin Resistance and Metabolic Syndrome Between Major Depressive Disorder (MDD) or MDD With Psychotic FeaturesTerminatedNCT01310140
• Tai Chi Training for Treating Depressed Chinese AmericansCompletedNCT01263730Not applicable
• Computerized Information-Processing Bias Retraining in Depressed AdolescentsCompletedNCT01147913Phase 2
• Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major DepressionCompletedNCT00961454Phase 1