M.D. Anderson Cancer Center: Neoplasm Metastasis trials

The registry lists 79 Neoplasm Metastasis studies with M.D. Anderson Cancer Center as lead sponsor. 17 are open to participants now and 20 have results posted.

Early Phase 1 2Phase 1 26Phase 2 37Phase 3 9Phase 4 1No phase 19(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Phase 2 Trial Of Sacituzumab Tirumotecan For Treatment Of Refractory Metastatic Or Unresectable Squamous Cell Carcinoma Of The Anus/RectumNot yet recruitingNCT07511023Phase 2
• Phase 1/2 Window Of Opportunity Study Of TROP2 CAR/IL-15 TGFBR2 KO NK Cells Delivered Intraperitoneally For The Management Of Gastric Cancer Metastatic To The PeritoneumRecruitingNCT07509008Phase 1/2
• Phase 2 Trial of Zanzalintinib and Pembrolizumab in Select Subtypes of Advanced/Metastatic Soft-tissue SarcomaRecruitingNCT07283731Phase 2
• A Study of the ApricityCare Program for Early Detection and Management of Treatment-Related Adverse Events in Patients With CancerRecruitingNCT06693687Not applicable
• A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)RecruitingNCT05673928Phase 2
• Triage of Advanced Cervical Cancer Through Immunotherapy Induction (TRACTION)RecruitingNCT05475171Phase 2
• Preoperative Y-90 Radioembolization for Tumor Control and Future Liver Remnant Hypertrophy in Patients With Colorectal Liver MetastasesRecruitingNCT05195710Phase 1
• Improving Processes of Cancer Care Delivery at a Comprehensive Cancer CenterNot yet recruitingNCT05095948
• Parenting Support Intervention for Families Coping With Metastatic or Locally Recurrent Solid Tumor DiagnosisRecruitingNCT05059678Not applicable
• Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid MalignanciesRecruitingNCT05039632Phase 1/2
• Larotrectinib for the Treatment of NTRK Amplification Positive, Locally Advanced or Metastatic Solid TumorsRecruitingNCT04879121Phase 2
• Adoption of Audio Recording in the Outpatient Supportive Care CenterNot yet recruitingNCT04871477
• Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid TumorsRecruitingNCT04771520Phase 2
• Talazoparib and Palbociclib, Axitinib, or Crizotinib for the Treatment of Advanced or Metastatic Solid Tumors, TalaCom TrialRecruitingNCT04693468Phase 1
• Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME TrialRecruitingNCT04693377Not applicable
• HSV G207 in Children With Recurrent or Refractory Cerebellar Brain TumorsRecruitingNCT03911388Phase 1
• Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"RecruitingNCT01365169Not applicable
• A Phase II Study of Futibatinib and Pembrolizumab in Metastatic Microsatellite Stable Endometrial CarcinomaTerminatedNCT05036681Phase 2Results posted
• Advanced MRI Scan Before and After Radiation Therapy for the Detection of Intracranial MetastasisCompletedNCT04870645Not applicableResults posted
• Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain MetastasesTerminatedNCT04789668Phase 1/2Results posted
• Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid TumorsActive, not recruitingNCT04266912Phase 1/2Results posted
• BMS-986156, Ipilimumab, and Nivolumab With or Without Stereotactic Body Radiation Therapy in Treating Patients With Advanced or Metastatic Lung/Chest or Liver CancersCompletedNCT04021043Phase 1/2Results posted
• Avelumab, Utomilumab, Anti-OX40 Antibody PF-04518600, and Radiation Therapy in Treating Patients With Advanced MalignanciesActive, not recruitingNCT03217747Phase 1/2Results posted
• Anamorelin Hydrochloride, Physical Activity, and Nutritional Counseling in Decreasing Cancer-Related Fatigue in Patients With Incurable Metastatic or Recurrent Solid TumorsActive, not recruitingNCT03035409Phase 2Results posted
• Haloperidol With or Without Chlorpromazine in Treating Delirium in Patients With Advanced, Metastatic, or Recurrent CancerActive, not recruitingNCT03021486Phase 2/3Results posted
• Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are MetastaticActive, not recruitingNCT02721732Phase 2Results posted
• Telemonitoring After Surgery to Preserve Limb Function in Optimizing Mobility in Cancer Survivors With Skeletal MetastasesTerminatedNCT02715856Not applicableResults posted
• Physical Activity and Dexamethasone in Reducing Cancer-Related Fatigue in Patients With Advanced CancerActive, not recruitingNCT02491632Phase 2/3Results posted
• A Randomized Trial Evaluating Rapid Delivery of Dose Escalated Hypofractionated Radiotherapy for Patients Diagnosed With Bone Metastases for Effective Palliation of SymptomsCompletedNCT02163226Phase 2/3Results posted
• Radium 223 in Castrate Resistant Prostate Cancer Bone MetastasesCompletedNCT02135484Not applicableResults posted
• Vandetanib and Everolimus in Treating Patients With Advanced or Metastatic CancerCompletedNCT01582191Phase 1Results posted
• Erlotinib and RAD001 (Everolimus) in Patients With Previously Treated Advanced Pancreatic CancerTerminatedNCT00640978Phase 2Results posted
• Dasatinib in Combination With Zoledronic Acid for the Treatment of Breast Cancer With Bone MetastasisCompletedNCT00566618Phase 1/2Results posted
• Dalteparin in Preventing DVT in Participants With CancerCompletedNCT00525057Not applicableResults posted
• Folfox-B Study for Patients With Colorectal Liver MetastasesTerminatedNCT00508872Phase 2Results posted
• Sm-EDTMP and Autologous Peripheral Blood Stem Cell Transplantation for Breast Cancer Patients With Bone Only MetastasesCompletedNCT00429507Phase 2Results posted
• Trastuzumab and RAD001 in Patients With Human Epidermal Growth Receptor 2 (HER-2) Overexpressing Breast CancerCompletedNCT00317720Phase 1/2Results posted
• A Phase 2 Study to Evaluate the Triplet Combination of Pemetrexed Plus AB928 (Etrumadenant) + AB122 (Zimberelimab) in Patients With Previously Treated Advanced or Metastatic MTAP Deficient Urothelial CarcinomaActive, not recruitingNCT05335941Phase 2
• Assessment of Verbal Comprehension and Cognitive Processes in Patients Admitted to the Palliative and Supportive Care UnitSuspendedNCT05091632
• Nivolumab for the Treatment of Metastatic or Unresectable Solid Tumors With ARID1A Mutation and CXCL13 ExpressionActive, not recruitingNCT04957615Phase 2
• Anti-CTLA4-NF mAb (BMS986218), Nivolumab, and Stereotactic Body Radiation Therapy for the Treatment of Metastatic Solid MalignanciesTerminatedNCT04785287Phase 1/2
• DS3201 and Ipilimumab for the Treatment of Metastatic Prostate, Urothelial and Renal Cell CancersActive, not recruitingNCT04388852Phase 1
• Cryoablation for the Treatment of Metastatic CancerActive, not recruitingNCT04150939Not applicable
• Frequency of Cachexia in Ambulatory Cancer Patients and Psychological Burden in Patients and Their Primary CaregiversActive, not recruitingNCT04090619
• Financial Distress in Advanced Cancer PatientsActive, not recruitingNCT04053517
• Open Labeled Placebo in Reducing Cancer Related Fatigue in Patients With Advanced CancerActive, not recruitingNCT03927885Phase 2/3
• Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative CareActive, not recruitingNCT03743649Phase 2/3
• ALRN-6924 and Paclitaxel in Treating Patients With Advanced, Metastatic, or Unresectable Solid TumorsCompletedNCT03725436Phase 1
• Preference of Room Setting and Waiting Time in Patients With Advanced, Locally Advanced, or Metastatic Cancer and Their Caregivers Who Are Seen in the Outpatient Supportive/Palliative Care CenterActive, not recruitingNCT03671226Not applicable
• Physical Activity With or Without Dexamethasone in Reducing Cancer-Related Fatigue in Patients With Locally Advanced, Metastatic, or Recurrent CancerActive, not recruitingNCT03583255Phase 2
• Levorphanol as a Second Line Opioid in Reducing Pain in Patients With CancerTerminatedNCT03579446Early Phase 1
• A Study of Cancer Related Fatigue in Patients With Metastatic Cancer Receiving Anti-PD1 ImmunotherapyActive, not recruitingNCT03525873Phase 3
• Combination Chemotherapy, Total Body Irradiation, and Donor Blood Stem Cell Transplant in Treating Patients With Primary or Secondary MyelofibrosisCompletedNCT03426969Early Phase 1
• Neratinib and Everolimus, Palbociclib, or Trametinib in Treating Participants With Refractory and Advanced or Metastatic Solid Tumors With EGFR Mutation/Amplification, HER2 Mutation/Amplification, or HER3/4 Mutation or KRAS MutationTerminatedNCT03065387Phase 1
• Salvage Radiation Therapy in Treating Patients With Metastatic Cancer That Has Progressed After Systemic ImmunotherapyCompletedNCT02710253Phase 2
• Ipilimumab (Immunotherapy) and MGN1703 (TLR Agonist) in Patients With Advanced Solid MalignanciesTerminatedNCT02668770Phase 1
• Safety Evaluation of Intra-Operative MRI-Based Guidance for Laser Ablation of Epidural MetastasisCompletedNCT02613390Not applicable
• Cement Augmentation in Preventing Vertebral Body Compression Fracture Following Spine Stereotactic Radiosurgery in Patients With Solid Tumors and Spinal MetastasesActive, not recruitingNCT02387905Phase 2
• Ceritinib and Everolimus in Treating Patients With Locally Advanced or Metastatic Solid Tumors or Stage IIIB-IV Non-small Cell Lung CancerActive, not recruitingNCT02321501Phase 1
• Talazoparib in Treating Patients With Recurrent, Refractory, Advanced, or Metastatic Cancers and Alterations in the BRCA GenesActive, not recruitingNCT02286687Phase 2
• Initiative for Molecular Profiling and Advanced Cancer Therapy (IMPACT II)Active, not recruitingNCT02152254Phase 2
• Vemurafenib, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or That Cannot Be Removed by SurgeryCompletedNCT01787500Phase 1
• Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain MetastasesActive, not recruitingNCT01592968Phase 3
• Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign DiseaseTerminatedNCT01552434Phase 1
• Hormone Receptor Positive Disease Across Solid Tumor Types: A Phase I Study of Single-Agent Hormone Blockade and Combination Approaches With Targeted Agents to Provide Synergy and Overcome ResistanceCompletedNCT01197170Phase 1
• Phase I Trial of Bevacizumab and Temsirolimus in Combination With 1) Carboplatin, 2) Paclitaxel, 3) Sorafenib for the Treatment of Advanced CancerActive, not recruitingNCT01187199Phase 1
• Aggressive Local Therapy for Limited Bone-Only Metastasis to Improve Progression-Free Survival in Breast Cancer PatientsActive, not recruitingNCT00929214Phase 2
• Hepatic Arterial Infusion of Nab-Paclitaxel in Patients With Metastatic Melanoma in the LiverCompletedNCT00833807Phase 1
• Correlation of MR Thermal Imaging to Actual Size of Ablation During Laser Ablation TherapyCompletedNCT00688038Phase 4
• Whole Body Magnetic Resonance Imaging (MRI) for Detection of Cancer MetastasesCompletedNCT00592462
• Valproate and Etoposide for Patients With Neuronal Tumors and Brain MetastasesCompletedNCT00513162Phase 1
• Surgery Versus Stereotactic Radiosurgery in the Treatment of Single Brain Metastasis: A Randomized TrialCompletedNCT00460395Phase 3
• Effects of Acupoint Electro-stimulation on Preventing Nausea and Vomiting Induced by Cisplatin or OxaliplatinWithdrawnNCT00430313Not applicable
• RAD001 Plus Docetaxel in Patients With Metastatic Breast CancerTerminatedNCT00253318Phase 1
• Docetaxel and Imatinib Mesylate in Treating Patients With Androgen-Independent Prostate Cancer and Bone Metastases That Progressed on the Docetaxel and Placebo Group of MDA-ID-030008CompletedNCT00084825Phase 2
• Docetaxel With or Without Imatinib Mesylate in Treating Patients With Androgen-Independent Prostate Cancer and Bone MetastasesCompletedNCT00080678Phase 2
• Assessment of Head and Neck Tumor Hypoxia Using 18F-FluoromisonidazoleWithdrawnNCT00038038Not applicable
• High Dose I-131 Metaiodobenzylguanidine(MIBG) for Metastatic Neuroendocrine TumorsCompletedNCT00037869Phase 3
• Safety, Efficacy and Pharmacokinetic Between Capecitabine and Exisulind in Metastatic Breast Cancer PatientsCompletedNCT00037609Phase 1/2