Hospices Civils de Lyon: Telangiectasia, Hereditary Hemorrhagic trials

The registry lists 18 Telangiectasia, Hereditary Hemorrhagic studies with Hospices Civils de Lyon as lead sponsor. 2 are open to participants now and 0 have results posted.

Phase 1 1Phase 2 4Phase 3 3No phase 11(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Immunological Effects of Iron Supplementation in HHT DiseaseRecruitingNCT07111598Not applicable
• Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 StudyRecruitingNCT04194619
• IV Bevacizumab Treatment of Patients With Hereditary Hemorrhagic Telangiectasia (HHT) or Rendu-Osler (RO) Disease: A Retrospective Analysis of French Cohort Data From 2009 to 2024CompletedNCT07772050
• Description of the Impact of Symptoms on Quality of Life in HHT Disease: DISQUOCompletedNCT07191639
• Stress-Echography in Hereditary Haemorrhagic Telangiectasia Patient With Hepatic InvolvementCompletedNCT05954481Not applicable
• Genotype Expression and Phenotype of Endothelial Cells, Carrying an ACVRL1, ENG or SMAD4 Mutation, in Response to BMP9 for the Identification of New Therapeutic Targets in Hereditary Haemorrhagic TelangiectasiaCompletedNCT05632484Not applicable
• Diagnostic Value of Ultra-low Dose Thoracic Scanner for the Pulmonary Arteriovenous Malformation Detection in HHT PatientCompletedNCT04108052Not applicable
• Efficacy of Nintedanib Per os as a Treatment for Epistaxis in HHT Disease.CompletedNCT03954782Phase 2
• Recurrence of Hereditary Hemorrhagic Telangiectasia (HHT) After Liver TransplantationCompletedNCT03942315
• Pulmonary Arteriovenous Malformations (PAVMs) in Hereditary Haemorrhagic Telangiectasia (HHT)CompletedNCT03940014
• Development of a Quality of Life Measurement Scale in Hereditary Haemorrhagic Telangiectasia (HHT) Disease.CompletedNCT03695874
• Evaluation of Obstetrical and Neonatal Complications in Hereditary Haemorrhagic Telangiectasia (HHT)CompletedNCT03691142
• BABH Study: Efficacy and Safety of Bevacizumab on Severe Bleedings Associated With Hemorrhagic Hereditary Telangiectasia (HHT).CompletedNCT03227263Phase 3
• Efficacy of a Timolol Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) - (TEMPO)CompletedNCT02484716Phase 2
• Efficacy of a Bevacizumab Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)TerminatedNCT02106520Phase 2/3
• The ELLIPSE Study: A Phase-1 Study Evaluating the Tolerance of Bevacizumab Nasal Spray to Treat Epistaxis in Hereditary Hemorrhagic TelangiectasiaCompletedNCT01507480Phase 1
• Efficacy and Safety of Bevacizumab for the Treatment Hemorrhagic Hereditary Telangiectasia (HHT) Associated With Severe Hepatic Vascular Malformations. Phase II StudyCompletedNCT00843440Phase 2
• ATERO : A Randomised Study With Tranexamic Acid in Epistaxis of Rendu Osler SyndromeCompletedNCT00355108Phase 3