Tyrosine Kinase Inhibitors: all 10,469 studies that test it

Page 51 of 105. Open to participants first (1,907), then studies with results posted, then the rest; newest registration first within each.

• A Study Evaluating How Moderate Liver Impairment Affects the Absorption, Distribution, Metabolism, and Elimination of Sevabertinib After a Single Oral DoseCompletedNCT07102095Phase 1
• A Randomized, Double-blind, Placebo-controlled Phase I Clinical Trial to Evaluate the Safety and Pharmacokinetic Profile of Single and Multiple Dose Escalation Topical Dermal Administration of SHR0302 Alkali Gel in Healthy SubjectsCompletedNCT07098117Phase 1
• Durvalumab and Tremelimumab With Lenvatinib as First-line Treatment in Patients With Unresectable Hepatocellular CarcinomaActive, not recruitingNCT07081633Phase 2
• Upadacitinib for Refractory Behcet's SyndromeCompletedNCT07080346Phase 2
• A Study to Evaluate the Relative Bioavailability of Two Tablet Formulations Compared to Capsule Formulation and the Effect of Food and Proton Pump Inhibitor on ZN-A-1041 Tablet(s) in Healthy ParticipantsCompletedNCT07051993Phase 1
• Intranasal Administration of Dodecyl Creatine Ester (CBT101) in Healthy Male SubjectsCompletedNCT07050316Phase 1
• Vorolanib Monotherapy or in Combination With Toripalimab as Adjuvant Therapy for Patients With Intermediate-high Risk of Recurrence in Renal Cell CarcinomaActive, not recruitingNCT07047001Phase 2
• Efficacy of Oral Tofacitinib in Combination of Narrow Band UVB in Treatment of VitiligoActive, not recruitingNCT07044141Phase 1
• Radiotherapy Plus Anlotinib in LA-NSCLC Intolerable to cCRTCompletedNCT07037680Phase 2
• A Study to Investigate the Pharmacokinetics and Safety of Remibrutinib in Participants With Severe Renal Impairment Compared to Matched Healthy Participants.CompletedNCT07032272Phase 1
• A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants in Japan With Alopecia AreataActive, not recruitingNCT07023302Phase 3
• A Study of the Pharmacokinetic Interaction Between Pirfenidone, Nintedanib, and Nalbuphine Extended Release (NAL ER) in Healthy ParticipantsCompletedNCT07015398Phase 1
• A Clinical Trial of Neoadjuvant Targeted Therapy, Immunotherapy, and Lysogenic HSV-Based Virotherapy in Resectable Head and Neck Squamous Cell CarcinomaActive, not recruitingNCT07010120Phase 1/2
• Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot StudyCompletedNCT07000734Phase 2
• Efficacy and Tolerability of Deucravacitinib in the Management of Palmoplantar PustulosisTerminatedNCT07000630Not applicable
• TGRX-678 Pharmacokinetic Mass BalanceCompletedNCT06986772Phase 1
• A Study Comparing Zasocitinib (TAK-279) With Deucravacitinib in Adults With Plaque PsoriasisCompletedNCT06973291Phase 3
• Zanzalintinib in Combination With Ipilimumab and Nivolumab in Patients With Metastatic Soft Tissue SarcomaSuspendedNCT06968988Phase 1
• A Study of Filgotinib 200 mg in Korean Participants With Moderately to Severely Active Ulcerative Colitis Under Routine Clinical PracticeActive, not recruitingNCT06964113Phase 4
• An Investigational Study of ESK-001 in Participants With Normal Renal Function and Participants With Mild, Moderate, and Severe Impaired Renal FunctionCompletedNCT06962774Phase 1
• Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS1)Active, not recruitingNCT06959225Phase 3
• Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS2)Active, not recruitingNCT06958211Phase 3
• An Investigational Study of ESK-001 in Participants With Normal Liver Function and Participants With Mild, Moderate, and Severe Liver DamageCompletedNCT06952634Phase 1
• A Single-arm, Multicenter Exploratory Clinical Trial of Anlotinib Combined With TQB2450 and the SOX Regimen as First-line Treatment for Advanced Gastric Cancer With Low PD-L1 ExpressionActive, not recruitingNCT06939452Phase 2
• Regorafenib and Yttrium-90 Radioembolization for Unresectable Hepatocellular CarcinomaWithdrawnNCT06902246Phase 2
• Exploratory Study of Inhaled Afatinib Dimaleate PK ProfileTerminatedNCT06897735Phase 1
• Carboplatin/Cisplatin + Etoposide + Benmelstobart Sequential Benmelstobart Combined With Anlotinib Versus Carboplatin/Cisplatin + Etoposide + Tislelizumab Sequential Tislelizumab in the Treatment of Extensive Stage Small Cell Lung CancerTerminatedNCT06897579Phase 2
• A Study to Evaluate the Effect of a High-fat Meal on the Exposure of Pimicotinib Capsule in Healthy SubjectsActive, not recruitingNCT06884072Phase 1
• A Study to Evaluate Efficacy of Remibrutinib Compared to Dupilumab at Early Timepoints in Adults With Chronic Spontaneous Urticaria Inadequately Controlled by Second Generation H1-antihistaminesActive, not recruitingNCT06868212Phase 3
• Study of Adaptive Immunotherapy With VEGFR-TKI in Patients With Advanced RCCSuspendedNCT06860386Phase 2
• Neoadjuvant Therapy for Locally Advanced Rectal CancerActive, not recruitingNCT06853769Early Phase 1
• A Study to Evaluate the Bioequivalence Between Immediate Release Tablets and Minitablets of Deucravacitinib (BMS-986165), and the Effect of Food and pH on the Drug Levels of the Minitablets in Healthy AdultsCompletedNCT06851871Phase 1
• A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis SuppurativaActive, not recruitingNCT06840392Phase 3
• A Study to Investigate the Sequencing Strategy of Pirtobrutinib After Disease Progression on First-line Acalabrutinib Treatment for Adult Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaWithdrawnNCT06839872Phase 2
• A Study to Assess the Efficacy and Safety of PG-011 Nasal Spray in Adults With Moderate to Severe Seasonal Allergic RhinitisCompletedNCT06837233Phase 2
• A Study to Assess the Efficacy and Safety of Ruxolitinib Cream in Children and Adolescents (6 to <18 Years Old) With Moderate Atopic DermatitisActive, not recruitingNCT06832618Phase 3
• Combination of Vebreltinib and Osimertinib in Patients with EGFR 21 L858R Mutation Advanced NSCLCActive, not recruitingNCT06827145Phase 2
• Tazemetostat in Combination With Zanubrutinib and Anti-CD20 Monoclonal Antibody in Relapsed or Refractory B-cell Non-Hodgkin LymphomaActive, not recruitingNCT06824701Phase 1
• A Study on the Substance Balance of [14C]XY0206 in Healthy Adult Chinese MenCompletedNCT06823232Phase 1
• Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the BodyTerminatedNCT06820957Phase 2/3
• High-dose Furmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Meningeal MetastasisCompletedNCT06812871Phase 2
• A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa (RECHARGE 1)Active, not recruitingNCT06799000Phase 3
• Ritlecitinib (PF-06651600) in Participants With Chronic Spontaneous UrticariaWithdrawnNCT06795373Phase 2
• A Study of AL8326 in Non-Small Cell Lung CancerActive, not recruitingNCT06794957Phase 1
• A Study of Interaction of Zasocitinib (TAK-279) With Other Medicines in Healthy AdultsCompletedNCT06793943Phase 1
• A Trial of SHR0302Base in Patients With VitiligoActive, not recruitingNCT06790862Phase 2
• A Study to Investigate The Effect of Pimicotinib on The Pharmacokinetics of Metformin, Fexofenadine and Rosuvastatin In Healthy SubjectsCompletedNCT06779253Phase 1
• A Study of an FGFR2/3 Inhibitor (CGT4859) in Patients With Cholangiocarcinoma and Other Advanced Solid TumorsActive, not recruitingNCT06777316Phase 1/2
• Upadacitinib for Prurigo NodularisTerminatedNCT06773403Phase 4
• A Study to Evaluate the Effect of Food on Nemtabrutinib (MK-1026) in Healthy Participants (MK-1026-017)CompletedNCT06772818Phase 1
• A Study to Evaluate the Effect of Food on Nemtabrutinib (MK-1026) in Healthy Participants (MK-1026-016)CompletedNCT06772805Phase 1
• A Study to Evaluate QTc Prolongation With Quizartinib in Healthy Subjects Under Rapid Acceleration of Heart RateCompletedNCT06772246Phase 1
• CART123 + Ruxolitinib in Relapsed/Refractory AMLActive, not recruitingNCT06768476Phase 1
• Use of Selective JAK Inhibitor in ILD and Skin Tightness of Systemic Sclerosis Versus MMFCompletedNCT06758947Phase 3
• Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell Transplantation in Older Adult Patients With Acquired Aplastic AnemiaActive, not recruitingNCT06752694Phase 2
• A Phase 2 Study to Assess the Safety of EI-1071 and the Effects of EI-1071 on Neuroinflammation in Alzheimer's Disease PatientsCompletedNCT06745583Phase 2
• A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia GravisActive, not recruitingNCT06744920Phase 3
• A Clinical Study on Neoadjuvant Treatment of Resectable Head and Neck Squamous Carcinoma With Immune-targeted Therapy and Lysogenic HSV VirusWithdrawnNCT06741982Phase 1
• Study to Assess the Effect of a CYP3A Weak Inducer Rufinamide on Quizartinib Pharmacokinetics in Healthy SubjectsCompletedNCT06740825Phase 1
• Study to Evaluate the Pharmacokinetics and Pharmacodynamics of AZD4604 Given Via the Turbuhaler® Device in Adults With Mild Asthma.CompletedNCT06732882Phase 1
• Tyrosine Kinase 2 (TYK2) for GA and CSWithdrawnNCT06725264Phase 2
• A Clinical Gene Therapy Study With Hematopoietic Stem Cells for the Treatment, With Single Dose of Temferon, of Patients Suffering From Metastatic Renal Cell CarcinomaTerminatedNCT06716853Phase 1/2
• Safety and Efficacy of Upadacitinib in Combination With Topical Corticosteroids in Children From 2 to Less Than 12 Years of Age in Japan With Moderate to Severe Atopic DermatitisActive, not recruitingNCT06701331Phase 3
• Phase II Clinical Study of Adebrelimab Combined with Apatinib in the Treatment of Locally Advanced Non-small Cell Lung Cancer Patients with Radiation PneumonitisActive, not recruitingNCT06700421Phase 2
• A Study of the Effect of Efavirenz on the Plasma Levels of Nemtabrutinib (MK-1026-014)CompletedNCT06698016Phase 1
• TGRX-678 Phase I Oral Pharmacokinetic StudyCompletedNCT06697899Phase 1
• ONO-4059 Study in Patients With Steroid-resistant PemphigusActive, not recruitingNCT06696716Phase 3
• Upfront Ruxolitinib for Chronic Graft-vs-host DiseaseTerminatedNCT06695507Phase 1
• A Study to Evaluate the Relative Bioavailability of Two Different Pimicotinib Capsules in Healthy SubjectsCompletedNCT06694948Phase 1
• A Study to Test How Zongertinib is Taken up in the Blood of People With and Without Liver ProblemsCompletedNCT06692322Phase 1
• A Study of the Effects of Itraconazole on the Plasma Levels of Nemtabrutinib (MK-1026-013)CompletedNCT06688045Phase 1
• A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56Active, not recruitingNCT06683742Phase 3
• A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic MedicinesActive, not recruitingNCT06671496Phase 3
• A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUGANO) Primary Efficacy Will be Determined at Week 56Active, not recruitingNCT06668064Phase 3
• Baricitinib for Refractory Takayasu ArteritisCompletedNCT06662721Phase 2
• SPH3348 Tablets in a Single-center, Randomized, Open-label, Single-dose, Two-period, Two-sequence Crossover Design Food Effect Study in Healthy Chinese SubjectsCompletedNCT06652997Phase 1
• Zanubrutinib Plus Rituximab as Front-line Treatment for Mucosa-associated Lymphoid Tissue Lymphoma (MALT)Active, not recruitingNCT06647732Phase 2
• A Study of [14C]-LY3866288 in Healthy ParticipantsCompletedNCT06644378Phase 1
• A Study of LY3866288 in Healthy ParticipantsCompletedNCT06641037Phase 1
• A Study of the Effect of Nemtabrutinib (MK-1026) on the Plasma Levels of Digoxin in Healthy Participants (MK-1026-012)CompletedNCT06625827Phase 1
• A Study of Filgotinib in Korean Participants With Rheumatoid ArthritisCompletedNCT06625242Phase 4
• A Study to See How Well and How Safely Different Treatments Work in a Group of Participants With Non-Small Cell Lung Cancer (NSCLC)CompletedNCT06624059Phase 3
• A Clinical Trial to Evaluate the Effects of Itraconazole or Rifampicin on the Pharmacokinetics of VC004 Capsules in Healthy Adult SubjectsCompletedNCT06619951Phase 1
• Clinical Study to Evaluate Debio0123 + Sacituzumab Govitecan Combination in TNBC or HR+/HER2- Advanced Breast CancerActive, not recruitingNCT06612203Phase 1/2
• Study of HMPL-760 Plus R-GemOx Versus Placebo Plus R-GemOx in Relapsed/Refractory DLBCLCompletedNCT06601504Phase 2
• To Evaluate the Pharmacokinetics and Safety of TQ05105 Tablet in Renal Impairment SubjectsCompletedNCT06598956Phase 1
• Study to Investigate the Efficacy of Abrocitinib in Adult Participants With Severe Fatigue From Post COVID Condition/Long COVIDActive, not recruitingNCT06597396Phase 2
• A Study in Patients With Moderate to Severe Plaque Psoriasis to Evaluate the Efficacy and Safety of ESK-001CompletedNCT06588738Phase 3
• A Study to Compare Forms of Nemtabrutinib (MK-1026) in Healthy Adult Participants (MK-1026-007)CompletedNCT06586671Phase 1
• A Study to Evaluate the Efficacy and Safety of ESK-001 in Patients With Moderate to Severe Plaque PsoriasisCompletedNCT06586112Phase 3
• Study of ATI-2138 in Adult Participants With Moderate to Severe Atopic DermatitisCompletedNCT06585202Phase 2
• Orelabrutinib Followed by Response-adapted Ultra-low Dose 4Gy Radiation as First-line Treatment of MALT LymphomaActive, not recruitingNCT06583837Phase 2
• Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AMLActive, not recruitingNCT06578247Phase 3
• A Study to Assess the Extent of Drug Interaction Between BMS-986278 and Nintedanib, the Relative Bioavailability of BMS-986278 in Tablet and the Effect That Food Has on BMS-986278 in Tablet Formulations in Healthy ParticipantsCompletedNCT06568458Phase 1
• Study to Evaluate Drug Levels of Various Solid Gastro-retentive Formulations of Deucravacitinib (BMS-986165) in Healthy ParticipantsCompletedNCT06566768Phase 1
• The Study to Assess the Pharmacokinetics of Pimicotinib in Subjects With Mild and Moderate Hepatic Impairment Relative to Subjects With Normal Hepatic FunctionCompletedNCT06562946Phase 1
• A Study to Evaluate the Bioequivalence of Ruxolitinib Extended Release (XR) Tablets With Ruxolitinib Immediate Release (IR) Tablets Administered Orally in Healthy ParticipantsCompletedNCT06555081Phase 1
• A Study of TAK-279 in Participants With Moderate-to-Severe Plaque PsoriasisActive, not recruitingNCT06550076Phase 3
• Efficacy and Safety of Baricitinib in the Post-intracerebral Hemorrhage Pulmonary InjuryActive, not recruitingNCT06548802Phase 1/2
• Zanubrutinib, Obinutuzumab and Lenalidomide in Newly Diagnosed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)Active, not recruitingNCT06547944Phase 1

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