Tyrosine Kinase Inhibitors: all 10,469 studies that test it

Page 34 of 105. Open to participants first (1,907), then studies with results posted, then the rest; newest registration first within each.

• Phase 1/2a Dose Escalation Study in Participants With CLL, SLL, or NHLCompletedNCT01994382Phase 1/2Results posted
• Efficacy, Safety, and Pharmacokinetic of MSC2156119J in Asian Participants With Hepatocellular CarcinomaCompletedNCT01988493Phase 1/2Results posted
• A Study of the Effects of Posaconazole on Alectinib (RO5424802) Pharmacokinetics in Healthy VolunteersCompletedNCT01984229Phase 1Results posted
• Tepotinib With Gefitinib in Participants With Locally Advanced or Metastatic NSCLC (INSIGHT)CompletedNCT01982955Phase 1/2Results posted
• Study of Ibrutinib in Combination With Rituximab in Previously Untreated Subjects With Follicular LymphomaCompletedNCT01980654Phase 2Results posted
• Study of the Bruton's Tyrosine Kinase Inhibitor in Subjects With Relapsed/Refractory Marginal Zone LymphomaCompletedNCT01980628Phase 2Results posted
• Nintedanib Twice Daily vs Placebo in Patients Diagnosed With Idiopathic Pulmonary Fibrosis (IPF)CompletedNCT01979952Phase 3Results posted
• Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell LymphomaCompletedNCT01979536Phase 2Results posted
• Dose Escalation Pan-FGFR (Fibroblast Growth Factor Receptor) Inhibitor (Rogaratinib)CompletedNCT01976741Phase 1Results posted
• Open-Label Extension Study Of Tofacitinib In Psoriatic ArthritisCompletedNCT01976364Phase 3Results posted
• A Phase 2 Study of BGJ398 in Patients With Recurrent GBMCompletedNCT01975701Phase 2Results posted
• A Phase 1B Dose-escalation and Phase 2a Study of Carotuximab (TRC105) in Combination With Pazopanib in Patients With Advanced Soft Tissue SarcomaCompletedNCT01975519Phase 1/2Results posted
• A Study of PCI-32765 (Ibrutinib) in Combination With Either Bendamustine and Rituximab or Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Participants With Previously Treated Indolent Non-Hodgkin LymphomaCompletedNCT01974440Phase 3Results posted
• A Study of PCI-32765 (Ibrutinib) Versus Rituximab in Relapsed or Refractory Chronic Leukemia/LymphomaCompletedNCT01973387Phase 3Results posted
• Tivozanib As Maintenance Therapy In GYNTerminatedNCT01972516Phase 2Results posted
• A Study Of PF-06463922 An ALK/ROS1 Inhibitor In Patients With Advanced Non Small Cell Lung Cancer With Specific Molecular AlterationsCompletedNCT01970865Phase 1/2Results posted
• Momelotinib Versus Ruxolitinib in Subjects With MyelofibrosisCompletedNCT01969838Phase 3Results posted
• A Study of Baricitinib and Ciclosporin in Healthy ParticipantsCompletedNCT01968057Phase 1Results posted
• Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/ParagangliomaCompletedNCT01967576Phase 2Results posted
• A Phase II Study of Sirolimus and Erlotinib in Recurrent/Refractory Germ Cell TumorsTerminatedNCT01962896Phase 2Results posted
• Study of BTK Inhibitor, Ibrutinib in Combination With Carfilzomib in Subjects With Relapsed and Refractory Multiple MyelomaCompletedNCT01962792Phase 1/2Results posted
• A Study Investigating the Efficacy and Safety of ABT-494 Given With Methotrexate in Subjects With Rheumatoid Arthritis Who Failed Anti-Tumor Necrosis Factor (TNF) Biologic TherapyCompletedNCT01960855Phase 2Results posted
• Pazopanib Paediatric Phase II Trial Children's Oncology Group (COG) in Solid TumorsCompletedNCT01956669Phase 2Results posted
• Cabozantinib (XL-184) Monotherapy for Advanced CholangiocarcinomaCompletedNCT01954745Phase 2Results posted
• Basket Study of Neratinib in Participants With Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 MutationsTerminatedNCT01953926Phase 2Results posted
• Afatinib (BIBW 2992) in Advanced Non-Small Cell Lung Cancer Patients With EGFR MutationCompletedNCT01953913Phase 3Results posted
• Pilot Study to Evaluate the Efficacy of Ruxolitinib in Alopecia AreataCompletedNCT01950780Phase 2Results posted
• Nintedanib in Treating Patients With Advanced Non-Small Cell Lung Cancer Who Have Failed Up to Two Previous Chemotherapy RegimensCompletedNCT01948141Phase 2Results posted
• Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell TumorsCompletedNCT01946529Phase 2Results posted
• Phase II Safety and Efficacy Study of Crizotinib in East Asian Patients With ROS1 Positive, ALK Negative Advanced NSCLCCompletedNCT01945021Phase 2Results posted
• Phase I Dose Escalation Study of VS-6063 in Japanese Subjects With Non-Hematologic MalignanciesCompletedNCT01943292Phase 1Results posted
• A Study of the Effect of Multiple Doses of Rifampin on the Single Dose Pharmacokinetics of RO5424802CompletedNCT01940510Phase 1Results posted
• Colorectal Cancer Treated With Adjuvant Regorafenib Versus Placebo After Curative Treatment of Liver Metastases in a Randomized, Double-blind, Placebo-Controlled Phase-III STudyTerminatedNCT01939223Phase 3Results posted
• A Study of Baricitinib and Probenecid in Healthy ParticipantsCompletedNCT01937026Phase 1Results posted
• Cabozantinib S-Malate in Treating Patients With Recurrent or Metastatic Endometrial CancerCompletedNCT01935934Phase 2Results posted
• Study of Ponatinib in Patients With Lung Cancer Preselected Using Different Candidate Predictive BiomarkersCompletedNCT01935336Phase 2Results posted
• Cabazitaxel Plus Lapatinib as Therapy for HER2-Positive Metastatic Breast Cancer Patients With Intracranial MetastasesTerminatedNCT01934894Phase 2Results posted
• Effect of Vandetanib on Cellular Markers in Invasive Breast CancerTerminatedNCT01934335Phase 2Results posted
• Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior BevacizumabCompletedNCT01931098Phase 2Results posted
• Study of Chemotherapy With Cisplatin/Carboplatin, and Docetaxel With or Without Erlotinib in Patients With Head and Neck Squamous Cell Carcinomas Amenable for Surgical ResectionCompletedNCT01927744Phase 2Results posted
• A Study of Baricitinib and Omeprazole in Healthy ParticipantsCompletedNCT01925144Phase 1Results posted
• A Study of Baricitinib When Administered With Ketoconazole or Fluconazole in Healthy ParticipantsCompletedNCT01924299Phase 1Results posted
• Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine GliomasCompletedNCT01922076Phase 1Results posted
• Dacomitinib + Pemetrexed for Patients With Advanced Non-squamous Non-small Cell Lung Cancer (NSCLC)TerminatedNCT01918761Phase 1Results posted
• A Study of ENMD-2076 in Ovarian Clear Cell CancersCompletedNCT01914510Phase 2Results posted
• FOLFOX Plus Regorafenib in Patients With Unresectable or Metastatic Esophagogastric CancerCompletedNCT01913639Phase 2Results posted
• A Study of Baricitinib and Rifampicin in Healthy ParticipantsCompletedNCT01910311Phase 1Results posted
• Study of Cabozantinib (XL184) vs Placebo in Subjects With Hepatocellular Carcinoma Who Have Received Prior SorafenibCompletedNCT01908426Phase 3Results posted
• Nintedanib (BIBF 1120) in MesotheliomaTerminatedNCT01907100Phase 2/3Results posted
• Bosutinib Treatment Extension Study Only For Subjects With Chronic Myeloid Leukemia (CML) Who Have Previously Participated In Bosutinib Studies B1871006 Or B1871008CompletedNCT01903733Not applicableResults posted
• Sorafenib Tosylate and Yttrium Y 90 Glass Microspheres in Treating Patients With Liver Cancer That Cannot Be Removed by SurgeryCompletedNCT01900002Phase 2Results posted
• A Study of Baricitinib and Birth Control Pills in Healthy FemalesCompletedNCT01896726Phase 1Results posted
• A Study of Two Different Doses of Cabozantinib (XL184) in Progressive, Metastatic Medullary Thyroid CancerActive, not recruitingNCT01896479Phase 4Results posted
• Dose-finding Study of GLPG0634 as Monotherapy in Active Rheumatoid Arthritis (RA) Participants (DARWIN2)CompletedNCT01894516Phase 2Results posted
• Quizartinib With Azacitidine or Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic SyndromeCompletedNCT01892371Phase 1/2Results posted
• Phase II Trial to Validate Markers for a Response Evaluation of a Combined Therapy in Patients With HER2+ Breast CancerTerminatedNCT01891357Phase 2Results posted
• Maintenance Dovitinib for Colorectal and Pancreas CancerTerminatedNCT01888965Phase 2Results posted
• Dose-finding Study of GLPG0634 as add-on to Methotrexate in Active Rheumatoid Arthritis Participants (DARWIN1)CompletedNCT01888874Phase 2Results posted
• Rituximab and Bendamustine Hydrochloride, Rituximab and Ibrutinib, or Ibrutinib Alone in Treating Older Patients With Previously Untreated Chronic Lymphocytic LeukemiaActive, not recruitingNCT01886872Phase 3Results posted
• Tivozanib + Enzalutamide in Adv Prostate CancerTerminatedNCT01885949Phase 2Results posted
• An Extension Study in Participants With Moderate to Severe Rheumatoid ArthritisCompletedNCT01885078Phase 3Results posted
• Tofacitinib In Psoriatic Arthritis Subjects With Inadequate Response to TNF InhibitorsCompletedNCT01882439Phase 3Results posted
• Efficacy And Safety Of Tofacitinib In Psoriatic Arthritis: Comparator StudyCompletedNCT01877668Phase 3Results posted
• Study of the Safety and Activity of Lenvatinib (E7080) in Subjects With KIF5B-RET-Positive Adenocarcinoma of the LungCompletedNCT01877083Phase 2Results posted
• Dasatinib, Cytarabine, and Idarubicin in Treating Patients With High-Risk Acute Myeloid LeukemiaTerminatedNCT01876953Phase 1/2Results posted
• Evaluation of Efficacy, Safety of Vandetanib in Patients With Differentiated Thyroid CancerCompletedNCT01876784Phase 3Results posted
• Dendritic Cell Vaccines + Dasatinib for Metastatic MelanomaCompletedNCT01876212Phase 2Results posted
• A Phase 2 Trial of Ponatinib in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal TumorCompletedNCT01874665Phase 2Results posted
• Capecitabine, Cyclophosphamide, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With HER2-Positive Metastatic Breast CancerTerminatedNCT01873833Phase 2Results posted
• A Study of Alectinib (CH5424802/RO5424802) in Participants With Anaplastic Lymphoma Kinase (ALK)-Rearranged Non-Small Cell Lung Cancer (NSCLC)CompletedNCT01871805Phase 1/2Results posted
• Safety and Efficacy of INC280 and Buparlisib (BKM120) in Patients With Recurrent GlioblastomaTerminatedNCT01870726Phase 1/2Results posted
• A Pharmacokinetic Study of Baricitinib in Participants With Liver DiseaseCompletedNCT01870388Phase 1Results posted
• Lapatinib Ditosylate and Radiation Therapy in Treating Patients With Locally Advanced or Locally Recurrent Breast CancerTerminatedNCT01868503Phase 2Results posted
• Cabozantinib-S-Malate and Erlotinib Hydrochloride in Treating Patients With Previously Treated Metastatic Non-Small Cell Lung CancerCompletedNCT01866410Phase 2Results posted
• Cabozantinib (XL184) in Patients With Relapsed or Refractory MyelomaCompletedNCT01866293Phase 1/2Results posted
• A Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell CarcinomaCompletedNCT01865747Phase 3Results posted
• Nilotinib Roll-over Protocol for Patients in Novartis-sponsored Nilotinib Study and Benefiting From Nilotinib TreatmentCompletedNCT01863745Phase 2Results posted
• Tivantinib in Treating Patients With Previously Treated Malignant MesotheliomaTerminatedNCT01861301Phase 2Results posted
• A Drug Drug Interaction (DDI) Study of Baricitinib (LY3009104) and Digoxin in Healthy ParticipantsCompletedNCT01859078Phase 1Results posted
• A Study Of Dacomitinib (PF-00299804) In Patients With Advanced Non-Small Cell Lung CancerCompletedNCT01858389Phase 2Results posted
• Erlotinib Hydrochloride Before Surgery in Treating Patients With Stage III Non-Small Cell Lung CancerTerminatedNCT01857271Phase 2Results posted
• LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based ChemotherapyCompletedNCT01856478Phase 3Results posted
• A Study of the Bruton's Tyrosine Kinase Inhibitor, PCI-32765 (Ibrutinib), in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Newly Diagnosed Non-Germinal Center B-Cell Subtype of Diffuse Large B-Cell LymphomaCompletedNCT01855750Phase 3Results posted
• An Open Label Trial of Afatinib (Giotrif) in Treatment-naive (1st Line) or Chemotherapy Pre-treated Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Harboring EGFR Mutation(s)CompletedNCT01853826Phase 3Results posted
• Tivozanib in Recurrent, Platinum-Resistant Ovarian, Fallopian Tube or Primary Peritoneal CancerCompletedNCT01853644Phase 2Results posted
• Pharmacokinetics and Safety of Regorafenib (BAY73-4506) in Cancer Subjects With Severe Renal ImpairmentCompletedNCT01853046Phase 1Results posted
• Open-Label Study Evaluating Dasatinib Therapy Discontinuation in Patients With Chronic Phase Chronic Myeloid Leukemia With Stable Complete Molecular ResponseCompletedNCT01850004Phase 2Results posted
• HCV-RNA Kinetics During Sorafenib for Hepatocellular Carcinoma (HCC)TerminatedNCT01849588Phase 4Results posted
• Ibrutinib in Treating Patients With Relapsed or Refractory Follicular LymphomaActive, not recruitingNCT01849263Phase 2Results posted
• Tivozanib for Recurrent GlioblastomaCompletedNCT01846871Phase 2Results posted
• Open Label, Phase II Study to Evaluate Efficacy and Safety of Oral Nilotinib in Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia (CML) Pediatric Patients.CompletedNCT01844765Phase 2Results posted
• Pazopanib Hydrochloride in Treating Patients With Progressive Carcinoid TumorsActive, not recruitingNCT01841736Phase 2Results posted
• Ponatinib for Advanced Medullary Thyroid CancerTerminatedNCT01838642Phase 2Results posted
• Tivozanib in Treating Patients With Liver Cancer That Is Metastatic or Cannot Be Removed by SurgeryCompletedNCT01835223Phase 1/2Results posted
• Cabozantinib-s-malate or Sunitinib Malate in Treating Patients With Previously Untreated Locally Advanced or Metastatic Kidney CancerCompletedNCT01835158Phase 2Results posted
• Cabozantinib-S-Malate Compared With Temozolomide or Dacarbazine in Treating Patients With Metastatic Melanoma of the Eye That Cannot Be Removed by SurgeryCompletedNCT01835145Phase 2Results posted
• A Phase II Study of Cabozantinib (XL184) Therapy in Castrate Resistant Prostate Cancer (CRPC) With Visceral MetastasesCompletedNCT01834651Phase 2Results posted
• A Japanese Phase 1 Trial of c-Met Inhibitor MSC2156119J in Subjects With Solid TumorsCompletedNCT01832506Phase 1Results posted
• A Study of VEGF Tyrosine Kinase Inhibitor (Pazopanib) in Men With High-Risk Prostate Cancer Followed by Radical Prostatectomy and Pelvic Lymph Node DissectionCompletedNCT01832259Phase 2Results posted
• Dovitinib for Patients With Tumor Pathway Activations Inhibited by DovitinibCompletedNCT01831726Phase 2Results posted

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