Tyrosine Kinase Inhibitors: all 10,469 studies that test it

Page 21 of 105. Open to participants first (1,907), then studies with results posted, then the rest; newest registration first within each.

• Study of EYP-1901 in Patients With Nonproliferative Diabetic Retinopathy (NPDR)CompletedNCT05383209Phase 2Results posted
• Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD)CompletedNCT05381948Phase 2Results posted
• A Study to Learn About Abrocitinib Tablets in People With Atopic Dermatitis in IndiaCompletedNCT05375929Phase 3Results posted
• Efficacy and Safety of Delgocitinib Cream in Adolescents 12-17 Years of Age With Moderate to Severe Chronic Hand EczemaCompletedNCT05355818Phase 3Results posted
• A Study of Selpercatinib (LY3527723) in Healthy ParticipantsCompletedNCT05338515Phase 1Results posted
• Study of H2 Antagonist and a Proton Pump Inhibitor of Selpercatinib in Healthy ParticipantsCompletedNCT05338502Phase 1Results posted
• A Trial to Assess the Effect of Delgocitinib Cream 20 mg/g on the Molecular Signature, Safety, and Efficacy in Adults With Frontal Fibrosing AlopeciaCompletedNCT05332366Phase 2Results posted
• A Study of the Effect of Food on Selpercatinib (LY3527723) in Healthy ParticipantsCompletedNCT05324124Phase 1Results posted
• Tarlox and Sotorasib in Patients With KRAS G12C MutationsTerminatedNCT05313009Phase 1/2Results posted
• Lenvatinib Plus Pembrolizumab In Patients With Immune Checkpoint Inhibitor Naïve Metastatic Uveal MelanomaTerminatedNCT05308901Phase 2Results posted
• Topical Ruxolitinib in Chronic Hand DermatitisCompletedNCT05293717Phase 1/2Results posted
• A Study to Evaluate Long-term Safety of Nintedanib in Children and Adolescents With Interstitial Lung Disease (InPedILD®-ON)CompletedNCT05285982Phase 3Results posted
• A Phase 2b, Study of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)CompletedNCT05276063Phase 2/3Results posted
• Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 AlterationsTerminatedNCT05267106Phase 2Results posted
• Baricitinib for the Treatment of Ocular Mucous Membrane PemphigoidTerminatedNCT05263505Phase 2Results posted
• Study of Lenvatinib w/ Pembro in Black Participants w/Mismatch Repair-Prof Recurrent Endometrial CancerTerminatedNCT05263492Phase 2Results posted
• A 24 Week Trial to Compare the Efficacy and Safety of Delgocitinib Cream 20 mg/g Twice-daily With Alitretinoin Capsules Once-daily in Adult Participants With Severe Chronic Hand EczemaCompletedNCT05259722Phase 3Results posted
• Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Relapsed or Refractory Advanced Non-Small Cell Lung Cancer With an FGFR AlterationCompletedNCT05253807Phase 2Results posted
• Study of Bavituximab, Axitinib, and Avelumab in Advanced Hepatocellular CarcinomaTerminatedNCT05249569Phase 2Results posted
• DDI Study of Evobrutinib and CarbamazepineCompletedNCT05248945Phase 1Results posted
• A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream With Phototherapy in Participants With VitiligoCompletedNCT05247489Phase 2Results posted
• Neratinib and Capmatinib Combination (Phase Ib/II) in Metastatic Breast Cancer and Inflammatory Breast Cancer Patients With Abnormal HER-family and c-Met Pathway Activity as Measured by the CELsignia Signaling Analysis TestTerminatedNCT05243641Phase 1/2Results posted
• Osimertinib Plus Chemotherapy in Uncommon EGFRm NSCLCTerminatedNCT05215951Phase 2Results posted
• Tepotinib Drug-Drug Interaction Study With Carbamazepine in Healthy ParticipantsCompletedNCT05213481Phase 1Results posted
• Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid (VIPOR) for Diffuse Large B-cell Lymphoma Involving the Central Nervous SystemActive, not recruitingNCT05211336Phase 1Results posted
• Tepotinib Drug-Drug Interaction Study With Itraconazole in Healthy ParticipantsCompletedNCT05203822Phase 1Results posted
• Study of Ipilimumab, Nivolumab, and Cabozantinib in Patients With Cutaneous MelanomaTerminatedNCT05200143Phase 2Results posted
• Testing an Omega-3 Fatty Acid-Based Anti-Cancer Therapy for Patients With Triple-Negative Inflammatory Breast Cancer That Has Spread to Other Parts of the BodyTerminatedNCT05198843Phase 1/2Results posted
• Regorafenib and Durvalumab for the Treatment of High-Risk Liver CancerActive, not recruitingNCT05194293Phase 2Results posted
• Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket TrialCompletedNCT05189106Phase 1/2Results posted
• Baricitinib (LY3009104) in the Treatment of Cutaneous Lichen PlanusCompletedNCT05188521Phase 2Results posted
• Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal CarcinomatosisCompletedNCT05185947Phase 2Results posted
• Fedratinib in Myelodysplastic /Myeloproliferative Neoplasms (MDS/MPNs) and Chronic Neutrophilic Leukemia (CNL)CompletedNCT05177211Phase 2Results posted
• A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LY3527727) and Rosuvastatin in Healthy ParticipantsCompletedNCT05176314Phase 1Results posted
• A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)TerminatedNCT05160168Phase 1/2Results posted
• A Study to Evaluate the Efficacy, Safety, and Tolerability of NDI-034858 in Participants With Active Psoriatic ArthritisCompletedNCT05153148Phase 2Results posted
• A Relative Bioavailability Study of Selpercatinib (LY3527723) in Healthy ParticipantsCompletedNCT05136404Phase 1Results posted
• Study of the Effect of Food and a Proton Pump Inhibitor (PPI; Omeprazole) on LOXO-305 in Healthy ParticipantsCompletedNCT05134350Phase 1Results posted
• Study of the Effects of Itraconazole and Rifampin on LOXO-305 in Healthy ParticipantsCompletedNCT05134337Phase 1Results posted
• A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast CancerActive, not recruitingNCT05132582Phase 3Results posted
• A Target Occupancy Study With Ritlecitinib.CompletedNCT05128058Phase 1Results posted
• Ruxolitinib Cream in Participants With Facial and/or Neck Atopic Dermatitis InvolvementCompletedNCT05127421Phase 2Results posted
• A Study to Investigate the Efficacy of Fenebrutinib in Relapsing Multiple Sclerosis (RMS)Active, not recruitingNCT05119569Phase 2Results posted
• Study of Capmatinib in Indian Patients With MET Exon 14 Skipping Mutation Positive Advanced NSCLC.CompletedNCT05110196Phase 4Results posted
• Rilzabrutinib for the Treatment of Chronic Spontaneous Urticaria in Patients Who Remain Symptomatic Despite the Use of H1 AntihistamineCompletedNCT05107115Phase 2Results posted
• Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax in Combination With Intravenous (IV) Obinutuzumab or Oral Ibrutinib in Adult Participants With Untreated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)CompletedNCT05105841Phase 2Results posted
• Study to Evaluate the Effect of Multiple-Dose Ritlecitinib on the Pharmacokinetics (PK) of TolbutamideCompletedNCT05097716Phase 1Results posted
• A Study Comparing Two Formulations of Selpercatinib (LY3527723) in Healthy ParticipantsCompletedNCT05089019Phase 1Results posted
• Dual JAK1/TYK2 Inhibitor for Cicatricial AlopeciaCompletedNCT05076006Phase 2Results posted
• A Study of Baricitinib (LY3009104) in Children With COVID-19TerminatedNCT05074420Phase 3Results posted
• A Study of Repotrectinib in Combination With Other Anticancer Therapies for the Treatment of Subjects With KRAS-Mutant Solid TumorsTerminatedNCT05071183Phase 1/2Results posted
• Phase II Trial of Vemurafenib and Sorafenib in Pancreatic CancerCompletedNCT05068752Phase 2Results posted
• Treatment of CD79B Mutant Relapsed/Refractory Diffuse Large B-Cell Lymphoma With Bruton Tyrosine Kinase Inhibitor ZanubrutinibCompletedNCT05068440Phase 2Results posted
• A Study to Estimate the Effect of Multiple Dose Abrocitinib on Caffeine, Efavirenz, and Omeprazole in Healthy ParticipantsCompletedNCT05067439Phase 1Results posted
• A Study to Test How Well a Medicine Called Nintedanib Helps People in China With Progressive Lung FibrosisCompletedNCT05065190Phase 3Results posted
• Drug-Drug Interaction Study of Evobrutinib and Transporter SubstratesCompletedNCT05064488Phase 1Results posted
• A Study to Evaluate the Efficacy and Safety of INCB054707 in Participants With Prurigo NodularisCompletedNCT05061693Phase 2Results posted
• Study of Vimseltinib for Tenosynovial Giant Cell TumorActive, not recruitingNCT05059262Phase 3Results posted
• Cabozantinib and Pembrolizumab in Metastatic PancreasCompletedNCT05052723Phase 2Results posted
• A Safety and Efficacy Study of Remibrutinib in the Treatment of CSU in Japanese Adults Inadequately Controlled by H1-antihistaminesCompletedNCT05048342Phase 3Results posted
• Evaluation of Tofacitinib in Prevention of Photosensitivity in LupusCompletedNCT05048238Phase 1Results posted
• European Extension Study to Evaluate Safety and Efficacy of CTP-543 in Adults With Alopecia AreataCompletedNCT05041803Phase 3Results posted
• A Single Dose Study To Test Two Pediatric Forms Of Ritlecitinib Compared With Adult Ritlecitinib In Healthy AdultsCompletedNCT05040295Phase 1Results posted
• Efficacy of Abrocitinib for Reducing Pruritus in Adults With Prurigo Nodularis and Chronic Pruritus of Unknown OriginCompletedNCT05038982Phase 2Results posted
• Preventing Anaphylaxis With AcalabrutinibCompletedNCT05038904Phase 2Results posted
• A Phase II Study of Futibatinib and Pembrolizumab in Metastatic Microsatellite Stable Endometrial CarcinomaTerminatedNCT05036681Phase 2Results posted
• Evaluation of the Relative Bioavailability of Bosutinib Capsules Under Fed Condition and Estimation of Food Effect on Orally Administered Bosutinib CapsuleCompletedNCT05032690Phase 1Results posted
• A Phase 3 Study of Efficacy and Safety of Remibrutinib in the Treatment of CSU in Adults Inadequately Controlled by H1-antihistaminesCompletedNCT05032157Phase 3Results posted
• A Phase 3 Study of Efficacy and Safety of Remibrutinib in the Treatment of CSU in Adults Inadequately Controlled by H1 AntihistaminesCompletedNCT05030311Phase 3Results posted
• A Study to Evaluate Lanraplenib (LANRA) in Combination With Gilteritinib in Participants With FLT3-mutated Relapsed or Refractory Acute Myeloid Leukemia (AML)TerminatedNCT05028751Phase 1/2Results posted
• A Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab (BR) in Untreated Patients With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)Active, not recruitingNCT05023980Phase 3Results posted
• Entospletinib Plus Intensive Induction/Consolidation Chemotherapy in Newly Diagnosed NPM1-mutated AMLTerminatedNCT05020665Phase 3Results posted
• Proof of Concept Study of Rilzabrutinib in Adult Patients With Moderate-to-severe Atopic DermatitisCompletedNCT05018806Phase 2Results posted
• To Evaluate the Efficacy and Safety of Tislelizumab in Combination With Lenvatinib in Participants With Selected Solid TumorsCompletedNCT05014828Phase 2Results posted
• A Study of BMS-986166 or Branebrutinib for the Treatment of Participants With Atopic DermatitisCompletedNCT05014438Phase 2Results posted
• Study of NDI-034858 in Participants With Moderate to Severe Plaque PsoriasisCompletedNCT04999839Phase 2Results posted
• Phase 2a Study of the Safety, Tolerability, and Pharmacokinetics of Topically Administered PRN473 (SAR444727) in Patients With Mild to Moderate Atopic DermatitisCompletedNCT04992546Phase 2Results posted
• A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib FailureActive, not recruitingNCT04988295Phase 3Results posted
• A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CPActive, not recruitingNCT04971226Phase 3Results posted
• Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell CarcinomaTerminatedNCT04955743Phase 2Results posted
• Open-label Multi-site Extension Trial in Subjects Who Completed the DELTA 1 or DELTA 2 TrialsCompletedNCT04949841Phase 3Results posted
• Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Plus Chemotherapy in Participants With Metastatic Esophageal Carcinoma (MK-7902-014/E7080-G000-320/LEAP-014).TerminatedNCT04949256Phase 3Results posted
• The Purpose of the Study is to Continue to Provide Pemigatinib to Patients With Advanced Malignancies.TerminatedNCT04949191Phase 2Results posted
• Asciminib Treatment Optimization in ≥ 3rd Line CML-CPCompletedNCT04948333Phase 3Results posted
• A Study in Healthy Men to Test Whether Four Capsules of 25 mg Nintedanib Are Taken up in the Body in the Same Way as One 100 mg CapsuleCompletedNCT04938453Phase 1Results posted
• Acalabrutinib Study in Indian Patients With Chronic Lymphocytic Leukaemia & Relapsed and Refractory Mantle Cell LymphomaCompletedNCT04930536Phase 4Results posted
• Chemoradiation and Pembrolizumab Followed by Pembrolizumab and Lenvatinib Before Surgery for the Treatment of Non-metastatic Esophageal or Esophageal/Gastroesophageal Junction CancerActive, not recruitingNCT04929392Phase 2Results posted
• Study to Evaluate Adverse Events and Change in Disease Activity With Oral Tablets of Upadacitinib in Adult Participants With Non-Segmental VitiligoCompletedNCT04927975Phase 2Results posted
• Phase II of Neoadjuvant and Adjuvant Capmatinib in NSCLCTerminatedNCT04926831Phase 2Results posted
• Sitravatinib Plus Pembrolizumab in Patients With Advanced Treatment-Naïve PD-L1+ Non-Squamous NSCLCTerminatedNCT04925986Phase 2Results posted
• Novel Experimental COVID-19 Therapies Affecting Host ResponseCompletedNCT04924660Phase 2/3Results posted
• A Study to Assess the Efficacy and Safety of Ruxolitinib Cream in Children With Atopic Dermatitis (TRuE-AD3)CompletedNCT04921969Phase 3Results posted
• Tislelizumab in Combination With Sitravatinib in Participants With Locally Advanced or Metastatic Non-Small Cell Lung CancerTerminatedNCT04921358Phase 3Results posted
• Bioavailability of Bosutinib Administered as Capsule Contents Mixed With Applesauce or Yogurt Relative to Intact Capsules Under Fed ConditionCompletedNCT04916769Phase 1Results posted
• Study of Ruxolitinib Cream for the Treatment of Discoid Lupus ErythematosusCompletedNCT04908280Phase 2Results posted
• A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease-modifying Anti-rheumatic DrugsActive, not recruitingNCT04908202Phase 3Results posted
• A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor TreatmentActive, not recruitingNCT04908189Phase 3Results posted
• A Study Evaluating Relative Bioavailability of an Oral Suspension of Abrocitinib and Effect of an Acid Reducing Agent on the Bioavailability of Abrocitinib and Assessing the Taste of Abrocitinib Oral Formulations.CompletedNCT04903093Phase 1Results posted
• A Study to Evaluate the Mechanism of Action of Ruxolitinib Cream in Subjects With Vitiligo (TRuE-V MOA)CompletedNCT04896385Phase 2Results posted
• A Study of Bemcentinib for the Treatment of COVID-19 in Hospitalised PatientsCompletedNCT04890509Phase 2Results posted

← Tyrosine Kinase Inhibitors overview