Sitagliptin: all 313 studies that test it

Page 1 of 4. Open to participants first (12), then studies with results posted, then the rest; newest registration first within each.

• Disease-modifying Efficacy of Sitagliptin Therapy in Early-stage Parkinson's DiseaseNot yet recruitingNCT07804381Phase 2
• Sun Yat-Sen Treatment Strategy for Enhancing Response in Muscle-invasive Bladder CancerRecruitingNCT07717242Phase 2
• Sitagliptin With Pembro in RCC and MelanomaRecruitingNCT07634380Phase 1
• Sitagliptin in Recurrent/Progressive Grade 4 GliomaRecruitingNCT07541781Phase 1
• Metformin, Empagliflozin With Sitagliptin vs Linagliptin in Type 2 DiabetesEnrolling by invitationNCT07452913Phase 4
• Comparative Study Between (SGLT-2i) and (DPP-4i) in the Prevention of DICRecruitingNCT07436663Phase 4
• Neoadjuvant Chemotherapy, Anti-PD-1 Antibody and Sitagliptin for Locally Advanced pMMR CRCRecruitingNCT07365592Phase 1/2
• Effect of Add-on SGLT2i, TZD, or Combination Therapy in Type 2 Diabetes Patients on DPP4 InhibitorsNot yet recruitingNCT07108985Phase 4
• A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 GliomasRecruitingNCT07003542Phase 2
• Sitagliptin or BeiDouGen Capsule Improve the Pregnancy Outcome in Patients with PCOSRecruitingNCT06587698Not applicable
• Effects of Sitagliptin in Relatives of T1D PatientsNot yet recruitingNCT05219409Phase 2/3
• Sitagliptin for the Treatment of Type 2 DiabetesRecruitingNCT04495881Phase 4
• Anti-Diabetic Medications to Fight PD and LBDCompletedNCT06263673Phase 4Results posted
• A Research Study Comparing a New Medicine Oral Semaglutide to Sitagliptin in People With Type 2 DiabetesCompletedNCT04017832Phase 3Results posted
• Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1TerminatedNCT03738878Phase 4Results posted
• Sitagliptin and the Risk for Hypoglycaemia in Type 2 Diabetes PatientsCompletedNCT03359590Phase 2Results posted
• An Efficacy Study of Canagliflozin or Sitagliptin to Determine Glucose Variability in Mexican Participants With Type 2 Diabetes Mellitus Inadequately Controlled on MetforminCompletedNCT03267576Phase 4Results posted
• Safety and Efficacy of Bexagliflozin Compared to Sitagliptin as Add-on Therapy to Metformin in Type 2 Diabetes SubjectsCompletedNCT03115112Phase 3Results posted
• SNP Study of DPP-4 and GLP-1R in Chinese People (Including Diabetes Patients)CompletedNCT03108521Phase 4Results posted
• Interaction of Bexagliflozin With Metformin, Glimepiride and SitagliptinCompletedNCT02956044Phase 1Results posted
• Treatment of Diabetes in Patients With Systolic Heart FailureCompletedNCT02920918Phase 4Results posted
• Mechanistic Evaluation of Glucose-lowering Strategies in Patients With Heart FailureCompletedNCT02917031Phase 4Results posted
• A Study of the Safety and Efficacy of Sitagliptin Addition During Metformin Up-titration (MK-0431-848)CompletedNCT02791490Phase 3Results posted
• Sitagliptin in Non-Diabetic Patients Undergoing General SurgeryCompletedNCT02741687Phase 4Results posted
• Randomized Sitagliptin Withdrawal Study (MK-0431-845)CompletedNCT02738879Phase 3Results posted
• Sitagliptin for Prevention of Acute Graft Versus-Host Disease After Allogeneic Hematopoietic Stem Cell TransplantationCompletedNCT02683525Phase 2Results posted
• DPP4 Inhibition & Beta Cell FunctionCompletedNCT02683187Phase 1Results posted
• Remission Evaluation of a Metabolic Intervention in Type 2 Diabetes With Sitagliptin (REMIT-Sita)CompletedNCT02623998Phase 3Results posted
• Double-blind Sitagliptin Add-on Study in Japanese Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Ipragliflozin (MK-0431J-842)CompletedNCT02577016Phase 3Results posted
• Ipragliflozin Add-on Long-term Study in Japanese Participants With Type 2 Diabetes Mellitus on Sitagliptin (MK-0431J-849)CompletedNCT02564211Phase 3Results posted
• Sitagliptin for Hyperglycemia in Patients With T2DM Undergoing Cardiac SurgeryCompletedNCT02556918Phase 4Results posted
• Sitagliptin Therapy and Kinetics of Inflammatory MarkersCompletedNCT02536248Phase 3Results posted
• A Study to Assess the Addition of Sitagliptin to Metformin Compared With the Addition of Dapagliflozin to Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) and Mild Renal Impairment Who Have Inadequate Glycemic Control on Metformin With or Without a Sulfonylurea (MK-0431-838)CompletedNCT02532855Phase 3Results posted
• Sitagliptin for Reducing Inflammation and Immune ActivationCompletedNCT02513771Phase 2Results posted
• Sitagliptin in Non-Diabetic Patients Undergoing Cardiac SurgeryCompletedNCT02443402Phase 4Results posted
• The INDORSE Study: Inhibition of Dipeptidyl Peptidase IV: Outcomes on Renal Sodium ExcretionCompletedNCT02406443Phase 4Results posted
• Risk of Nocturnal Hypoglycemia and Arrhythmias With Sitagliptin Versus Glimepiride in Patients With Type 2 DiabetesTerminatedNCT02373865Phase 4Results posted
• Randomized Trial Comparing Sitagliptin to Placebo in Closed LoopCompletedNCT02328040Phase 1Results posted
• Efficacy of Sitagliptin and Glibenclamide on the Glucose Variability in Japanese Participants With Type 2 Diabetes Mellitus (MK-0431-355)CompletedNCT02318693Phase 4Results posted
• Dietary Impacts on Glucose-lowering Effects of Sitagliptin in Type 2 DiabetesCompletedNCT02312063Phase 4Results posted
• Study to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin in Combination With Metformin Compared to Sitagliptin in Combination With Metformin in Adult Patients With Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Therapy AloneCompletedNCT02284893Phase 3Results posted
• Sitagliptin and Glucagon CounterregulationCompletedNCT02256189Phase 4Results posted
• Efficacy and Safety of Ertugliflozin (MK-8835/PF-04971729) With Sitagliptin in the Treatment of Participants With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Diet and Exercise (MK-8835-017)CompletedNCT02226003Phase 3Results posted
• Effect of Chronic ACE and DPP4 Inhibition on Blood PressureCompletedNCT02130687Not applicableResults posted
• The Effect of Dipeptidyl Peptidase 4 Inhibition on Growth Hormone Secretion in Women With Polycystic Ovarian SyndromeCompletedNCT02122380Phase 4Results posted
• Ertugliflozin and Sitagliptin Co-administration Factorial Study (VERTIS FACTORAL, MK-8835-005)CompletedNCT02099110Phase 3Results posted
• Use of Sitagliptin to Decrease MicroalbuminuriaTerminatedNCT02048904Phase 4Results posted
• Januvia (Sitagliptin) in Healing Chronic Diabetic Foot UlcersTerminatedNCT02015910Phase 4Results posted
• Use of Sitagliptin for Stress Hyperglycemia or Mild Diabetes Following Cardiac SurgeryTerminatedNCT01970462Phase 4Results posted
• Sitagliptin Versus Placebo in the Treatment of Non-alcoholic Fatty Liver DiseaseCompletedNCT01963845Phase 2Results posted
• Impact of Sitagliptin on Cardiovascular Exercise Performance in Type 2 DiabetesCompletedNCT01951339Not applicableResults posted
• Antidiabetic Effects of Adding a DPP-4 Inhibitor to Pre-Existing Treatment With an Incretin Mimetic in Patients With T2DCompletedNCT01937598Phase 3Results posted
• Efficacy Study of Sitagliptin to Prevent New-onset Diabetes After Kidney TransplantCompletedNCT01928199Phase 4Results posted
• Efficacy and Safety of Switching From Sitagliptin to Liraglutide in Subjects With Type 2 Diabetes Not Achieving Adequate Glycaemic Control on Sitagliptin and MetforminCompletedNCT01907854Phase 4Results posted
• Effect of Chronic Incretin-based Therapy in Cystic FibrosisCompletedNCT01879228Not applicableResults posted
• Effects of Sitagliptin on Endothelial Function in Type 2 Diabetes on Background Metformin TherapyCompletedNCT01859793Phase 4Results posted
• Sitagliptin Therapy in Hospitalized Patients With Type 2 DiabetesCompletedNCT01845831Phase 4Results posted
• A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 DiabetesCompletedNCT01794143Phase 3Results posted
• A Pooled Analysis of the Safety and Efficacy of MK-0431A and MK-0431A XR in Pediatric Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Therapy (Alone or in Combination With Insulin) (MK-0431A-170/MK-0431A-289)CompletedNCT01760447Phase 3Results posted
• Multicenter Phase II of CD26 Using Sitagliptin for Engraftment After UBC TransplantCompletedNCT01720264Phase 2Results posted
• A Study to Assess the Safety and Tolerability of Sitagliptin/Simvastatin Fixed-dose Combination (FDC) in Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Monotherapy (MK-0431D-312)CompletedNCT01702298Phase 3Results posted
• Vildagliptin vs Sitagliptin add-on to Insulin - Impact on Glycemic Profile and Correlation of Hypoglycemic Episodes and Heart FunctionCompletedNCT01686932Phase 4Results posted
• A Study of the Efficacy and Safety of MK-0431D (a Fixed-dose Combination of Sitagliptin and Simvastatin) for the Treatment of Participants With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Metformin Monotherapy (MK-0431D-266)TerminatedNCT01678820Phase 3Results posted
• Contribution of Pancreatic αcells Function to Blood Glucose Regulation in Chinese Type 2 Diabetics- the Effect of Sitagliptin on Glucagon Secretion, Insulin Secretion and Insulin Resistance in Chinese Type 2 DiabeticsCompletedNCT01610154Phase 4Results posted
• Sitagliptin Regulation of Intestinal and Hepatic Lipoprotein Particle and Hepatic Glucose Production in HumansCompletedNCT01600703Phase 2/3Results posted
• A Study in China Evaluating the Safety and Efficacy of Adding Sitagliptin to Stable Therapy With Insulin With or Without Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) (MK-0431-254)CompletedNCT01590797Phase 3Results posted
• A Study in China Evaluating the Safety and Efficacy of Adding Sitagliptin to Stable Therapy With Sulfonylurea With or Without Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) (MK-0431-253)CompletedNCT01590771Phase 3Results posted
• A Study Comparing the Pharmacokinetic and Pharmacodynamic Profiles for Sitagliptin, Saxagliptin and Vildagliptin in Participants With Type 2 Diabetes Mellitus (T2DM) (MK-0431-142)CompletedNCT01582308Phase 1Results posted
• A Study to Assess the Pharmacokinetics and the Ability for Pediatric Participants With Type 2 Diabetes to Swallow MK-0431A XR Tablets (MK-0431A-296)CompletedNCT01557504Phase 1Results posted
• Effectiveness of Sitagliptin for HIV Insulin Resistance and InflammationCompletedNCT01552694Phase 3Results posted
• Sitagliptin Dose Determination StudyCompletedNCT01530178Phase 4Results posted
• Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and MetforminCompletedNCT01519674Phase 4Results posted
• Treatment of Diabetes After Gastric Bypass With SitagliptinCompletedNCT01512797Not applicableResults posted
• Study to Assess Safety & Efficacy of Sitagliptin as Initial Oral Therapy for Treatment of Type 2 Diabetes Mellitus in Pediatric Participants. (MK-0431-083)CompletedNCT01485614Phase 3Results posted
• A Study of the Co-administration of Sitagliptin and Atorvastatin in Inadequately Controlled Type 2 Diabetes Mellitus (MK-0431E-211)TerminatedNCT01477853Phase 3Results posted
• Study of Sitagliptin for the Treatment of Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Insulin (MK-0431-260)CompletedNCT01462266Phase 3Results posted
• Pharmacokinetics Study of Dipeptidyl Peptidase 4 Inhibitor to Control Type 2 Diabetes MellitusCompletedNCT01449747Phase 4Results posted
• A Study of LY2189265 and Sitagliptin in Participants With Type 2 DiabetesCompletedNCT01408888Phase 1Results posted
• Dose Response Finding Study of MK-0431/ONO-5435 in Japanese Subjects With Impaired Glucose Tolerance (MK-0431-105)CompletedNCT01405911Phase 2Results posted
• Dipeptidyl Peptidase-4 Inhibitor (Sitagliptin) Therapy in the Inpatients With Type 2 DiabetesCompletedNCT01378117Phase 4Results posted
• Changes in Bone Turnover With Increased Incretin Hormone ExposureTerminatedNCT01374568Phase 4Results posted
• Study to Compare Sitagliptin Versus Sulfonylurea Treatment During Ramadan Fasting in Patients With Type 2 Diabetes (MK-0431-262)CompletedNCT01340768Phase 3Results posted
• Sitagliptin and Kinetics of Triglyceride-rich Lipoproteins Apolipoprotein B48 and B100 in Patients With Type 2 DiabetesCompletedNCT01334229Phase 3Results posted
• Comparison of Two Treatment Regimens (Sitagliptin Versus Liraglutide) on Participants Who Failed to Achieve Good Glucose Control on Metformin Alone (MK-0431-403)CompletedNCT01296412Phase 3Results posted
• Dipeptidyl Peptidase-4 Inhibitors and Alpha-cell RecoveryCompletedNCT01272583Not applicableResults posted
• Adding Sitagliptin or Pioglitazone to Type 2 Diabetes Mellitus Insufficiently Controlled With Metformin and SulfonylureaCompletedNCT01195090Phase 4Results posted
• Safety and Efficacy of Sitagliptin Compared With Glimepiride in Elderly Participants With Type 2 Diabetes Mellitus (MK-0431-251)CompletedNCT01189890Phase 3Results posted
• Sitagliptin Therapy to Improve Outcomes After Islet AutotransplantCompletedNCT01186562Phase 4Results posted
• START-J: SiTAgliptin in eldeRly Trial in JapanCompletedNCT01183104Not applicableResults posted
• Clinical Trial to Evaluate the Safety and Efficacy of the Addition of Sitagliptin in Participants With Type 2 Diabetes Mellitus Receiving Acarbose Monotherapy (MK-0431-130)CompletedNCT01177384Phase 3Results posted
• Combination Therapy With Sitagliptin and Lansoprazole to Restore Pancreatic Beta Cell Function in Recent-Onset Type 1 DiabetesCompletedNCT01155284Phase 2Results posted
• Study of Sitagliptin Treatment in Patients With Type 2 Diabetes During Ramadan (0431-263)CompletedNCT01131182Phase 4Results posted
• A Study in Type 2 Diabetic Subjects on Stable Metformin Therapy to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Co-administering Single and Multiple Oral Doses of GSK1292263CompletedNCT01128621Phase 2Results posted
• A Study in Type 2 Diabetics of Single and Multiple Doses of Orally Administered GSK1292263 to Investigate the Safety, Tolerability, Pharmacokinetics and PharmacodynamicsCompletedNCT01119846Phase 2Results posted
• The Role of P-glycoprotein in Sitagliptin Clinical PharmacologyCompletedNCT01112670Phase 4Results posted
• Ketosis-Prone Diabetes Mellitus (KPDM): Metformin Versus Sitagliptin TreatmentCompletedNCT01099618Phase 4Results posted
• A Study of the Efficacy and Safety of Albiglutide in Subjects With Type 2 Diabetes With Renal Impairment.CompletedNCT01098539Phase 3Results posted
• Bioequivalence Study of Sitagliptin/Metformin Combination Tablet (MK0431A-122)CompletedNCT01093794Phase 1Results posted
• Dipeptidyl Peptidase-4 Inhibition and Immune Function in HIVCompletedNCT01093651Phase 2/3Results posted
• The Effects of Co-admin of Colesevelam and Sitagliptin on Glucose Metabolism in Subjects With Type 2 Diabetes MellitusCompletedNCT01092663Not applicableResults posted

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