SERMs: all 411 studies that test it

Page 1 of 5. Open to participants first (37), then studies with results posted, then the rest; newest registration first within each.

• A Study of Skipping Radiation Therapy in People With Breast CancerRecruitingNCT07895511Not applicable
• HRT-PC Trial: Hormone Recovery After Treatment for Prostate Cancer Trial. An Open-label Phase II Study of Clomiphene Citrate in Patients With Persistent Hypogonadism After ADT for Treatment of Localized Prostate CancerNot yet recruitingNCT07882862Phase 2
• Comparative Efficacy of Antioxidants Alone Versus Combined Therapy With SERMs or FSH in Normogonadotropic Idiopathic OAT Patients: A Randomized Controlled TrialNot yet recruitingNCT07862725Phase 4
• Efficacy and Safety of Dalpiciclib Combined With Endocrine Adjuvant Therapy for Early HR +/HER2- Breast Cancer: a Multicenter, Prospective Clinical StudyRecruitingNCT07581834Phase 2
• Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite AthletesEnrolling by invitationNCT07568574Not applicable
• Clinical Trial to Observe the Effects of Tamoxifen on Testosterone Recovery in Medically Castrated Prostate Cancer PatientsRecruitingNCT07535905Phase 2
• Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE GroupsEnrolling by invitationNCT07523022Phase 4
• Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast CancerNot yet recruitingNCT07499999Phase 2
• Memantine +/- Raloxifene for Cognitive Preservation After Radiation Therapy to the BrainRecruitingNCT07470606Phase 2
• Effect Clomiphene vs Clomiphene Along With Pioglitazone on Ovarian Stimulation RateRecruitingNCT07462065Phase 4
• Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators.RecruitingNCT07289035Phase 2
• A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)RecruitingNCT06979596Phase 2
• New Treatment Strategies and Epigenetic Biomarker for Management of Benign Prostatic HyperplasiaRecruitingNCT06944145Phase 2
• Tamoxifen for Advanced Solid Pseudopapillary Tumor of the PancreasRecruitingNCT06914674Phase 2
• Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian StimulationRecruitingNCT06701071Phase 4
• Tamoxifen and Pegylated Liposomal Doxorubicin for the Treatment of Patients With Metastatic or Inoperable, Locally Advanced Triple Negative Breast CancerRecruitingNCT06434064Phase 2
• Low Dose Exemestane vs Low Dose Tamoxifen in Post-menopausal Women at High Risk for Breast Cancer.RecruitingNCT06364267Phase 2
• Maintenance Hormonal Therapy and DLBCLNot yet recruitingNCT06355401Phase 2/3
• Assessing the Efficacy and Safety of Anti-HER2 Therapy in Nigerian Women With HER2+ Breast Cancer Before and After SurgeryRecruitingNCT06348134Phase 2
• Chemoprevention With Tamoxifen in Pre-Invasive Pancreas Mucinous Cystic Neoplasms Not Undergoing Immediate ResectionRecruitingNCT06320990Phase 1
• Optimizing Extended Adjuvant Endocrine Therapy in Patients With Breast CancerNot yet recruitingNCT06223698Phase 3
• Low Dose Tamoxifen With or Without Omega-3 Fatty Acids for Breast Cancer Risk ReductionRecruitingNCT06195306Phase 2
• Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE TrialRecruitingNCT06184750Phase 2
• Tamoxifen Prediction Study in Patients With ER+ Breast CancerRecruitingNCT05525481Phase 4
• ETHAN - ET for Male BCRecruitingNCT05501704Phase 2
• Sex Hormone Supplementation and Rotator Cuff Repair: A Preliminary Randomized TrialRecruitingNCT04944836Phase 2
• Tamoxifen Versus Etoposide After First Recurrence in GBM PatientsRecruitingNCT04765098Phase 2
• Impact of Neoadjuvant Hormonal Therapy on the Surgical Management of Extensive Ductal Carcinomas in SituRecruitingNCT04666961Phase 2
• Affect of Duavive on Mood & Anxiety SymptomsRecruitingNCT04478305Phase 1
• FES Imaging to Optimize Tamoxifen for Metastatic Breast CancerRecruitingNCT04174352Early Phase 1
• Bazedoxifene -Treatment for Women With SchizophreniaRecruitingNCT04113993Phase 4
• Radiotherapy Versus Low-Dose Tamoxifen Following Breast Conserving Surgery for Low-Risk Breast Ductal Carcinoma in SituRecruitingNCT04046159Phase 3
• A Window of Opportunity Study of Pre-operative Endocrine Therapy With and Without Prometrium in Postmenopausal Women With Early Stage Breast Hormone Receptor Positive (HR+) Human Epidermal Receptor 2 Negative (HER2-) Breast Cancer.RecruitingNCT03906669Phase 2
• Efficacy of Tamoxifen Versus Toremifene in CYP2D6 IM/PM of Premenopausal Patients With ER-positive Early Breast CancerRecruitingNCT03351062Phase 3
• Fertility Preservation Using Tamoxifen and Letrozole in Estrogen Sensitive Tumors TrialRecruitingNCT03011684Phase 3
• Endocrine Treatment Alone for Elderly Patients With Estrogen Receptor Positive Operable Breast Cancer and Low Recurrence ScoreRecruitingNCT02476786Phase 2
• Evaluation of Tamoxifen's Efficacy for ER/PR Negative,ER-beta Positive Operable Breast Cancer PatientsRecruitingNCT02062489Phase 3
• A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic CancerTerminatedNCT06630325Phase 2Results posted
• Study of Intravaginal Tamoxifen in PostMenopausal Women With VVACompletedNCT05378269Phase 1/2Results posted
• Randomized Controlled Trial of Combined Letrozole and Clomid (CLC II) Versus Letrozole Alone for Women With AnovulationActive, not recruitingNCT05206448Phase 4Results posted
• Multicenter Double Blind, Parallel-group Phase 2/3 Trial, to Study Raloxifene in Adult COVID-19 Patients.CompletedNCT05172050Phase 2/3Results posted
• Umbrella Trial of Subtype-Targeted Therapies in ER+/HER2- Breast CancerCompletedNCT05101564Phase 2Results posted
• Oral Tamoxifen vs. TamGel vs. Control in Women With Atypical Hyperplasia, Lobular Carcinoma In Situ, or Increased Breast Cancer RiskTerminatedNCT04570956Phase 2Results posted
• Study of Infigratinib in Combination With Tamoxifen in Hormone Receptor Positive, HER2 Negative, FGFR Altered Advanced Breast CancerTerminatedNCT04504331Phase 1Results posted
• The Effects of Short-term Preoperative Treatment With Hormonal Therapy on Gene Profiles in Breast CancerCompletedNCT04129216Phase 2Results posted
• Karolinska Interventional Study of Mammograhic Density (Karisma-1)CompletedNCT04079517Phase 1/2Results posted
• Anastrazole and Clomiphene to Evaluate Hypogonadal Symptoms and Erectile FunctionCompletedNCT03933618Phase 2Results posted
• Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause"CompletedNCT03740009Phase 4Results posted
• Tamoxifen Therapy to Treat Pulmonary Arterial HypertensionCompletedNCT03528902Phase 2Results posted
• Selective Estrogen Receptor Modulators to Enhance the Efficacy of Viral Reactivation With Histone Deacetylase InhibitorsCompletedNCT03382834Phase 2Results posted
• Low Dose Tamoxifen for Mammographic Density ReductionCompletedNCT03346200Phase 2Results posted
• A Study of Multiple Immunotherapy-Based Treatment Combinations in Hormone Receptor (HR)-Positive Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast CancerCompletedNCT03280563Phase 1/2Results posted
• Hypogonadotropic Hypogonadism in Obese Young MalesTerminatedNCT03245827Phase 2Results posted
• Neoadjuvant Endocrine Therapy in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Node-Negative Breast CancerCompletedNCT03219476Phase 2Results posted
• Trial of 4-Hydroxytamoxifen (4-OHT) Gel in Women Aimed at Reducing Dense Breast TissueTerminatedNCT03199963Phase 3Results posted
• Afimoxifene in Reducing the Risk of Breast Cancer in Women With Mammographically Dense BreastCompletedNCT03063619Phase 2Results posted
• Efficacy of High Dose Tamoxifen to Advanced Hormone Receptor-High Expressed Breast CancerCompletedNCT03045653Phase 2Results posted
• Testing an Active Form of Tamoxifen (4-hydroxytamoxifen) Delivered Through Breast Skin to Control Ductal Carcinoma in Situ (DCIS) of the BreastCompletedNCT02993159Phase 2Results posted
• Impact of Low-dose Tamoxifen on BPUCompletedNCT02979301Not applicableResults posted
• Treatment of Metastatic Breast Cancer With Fulvestrant Plus Palbociclib or Tamoxifen Plus PalbociclibCompletedNCT02913430Early Phase 1Results posted
• Treatment of Unfavorable Bleeding Patterns in Contraceptive Implant UsersCompletedNCT02903121Phase 4Results posted
• Tamoxifen to Reduce Unscheduled Bleeding in New Users of the Levonorgestrel-releasing Intrauterine System (LNG-IUS)CompletedNCT02824224Phase 4Results posted
• Neoadjuvant Tamoxifen in Locally Advanced Breast Cancer in a Low/Middle Income CountryCompletedNCT02806544Phase 2Results posted
• Combined Letrozole and Clomid in Women With Infertility and PCOSCompletedNCT02802865Phase 4Results posted
• Palbociclib in Combination With Tamoxifen as First Line Therapy for Metastatic Hormone Receptor Positive Breast CancerCompletedNCT02668666Phase 2Results posted
• A Multi-Center Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Body Composition and Metabolic Parameters With Diet and Exercise in Conjunction With Treatment With 12.5 mg or 25 mg EnclomipheneCompletedNCT02651688Phase 2Results posted
• A Study of Palbociclib in Combination With Bazedoxifene in Hormone Receptor Positive Breast CancerCompletedNCT02448771Phase 1/2Results posted
• A Study of Palbociclib in Combination With Fulvestrant or Tamoxifen as Treatment for Metastatic Breast CancerCompletedNCT02384239Phase 2Results posted
• Tamoxifen Citrate or Z-Endoxifen Hydrochloride in Treating Patients With Locally Advanced or Metastatic, Estrogen Receptor-Positive, HER2-Negative Breast CancerActive, not recruitingNCT02311933Phase 2Results posted
• Study Evaluating the Timing of Intrauterine Insemination in Relation to Positive Home Ovulation Prediction KitCompletedNCT02294773Not applicableResults posted
• Clomiphene Citrate for Treatment of AcromegalyCompletedNCT02274311Phase 2Results posted
• Bazedoxifene/Conjugated Estrogens (BZA/CE) Improvement of Metabolism (BIM)CompletedNCT02237079Phase 4Results posted
• Endocrine Response in Women With Invasive Lobular Breast CancerCompletedNCT02206984Phase 2Results posted
• Evaluation the Treatment of Tamoxifen of Low/Intermediate Risk Bladder TumorsCompletedNCT02197897Phase 2Results posted
• To Assess Safety and Effect of Olaparib on the Pharmacokinetics of Anastrozole, Letrozole & Tamoxifen, and Their Effect on Olaparib, in Patients With Advanced Solid CancerCompletedNCT02093351Phase 1Results posted
• Tamoxifen for the Treatment of Unfavorable Bleeding in Contraceptive Implant UsersCompletedNCT02070692Phase 4Results posted
• Comparison of Two Formulations of AndroxalCompletedNCT01984398Phase 1Results posted
• A Dose Escalating Study to Determine the Tolerability and PK of a Single Dose of AndroxalCompletedNCT01959685Phase 1Results posted
• Maximal Stimulation and Delayed Fertilization for Diminished Ovarian Reserve: a Randomized Pilot StudyCompletedNCT01921166Phase 4Results posted
• Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication AdministrationCompletedNCT01880086Phase 2Results posted
• Preoperative Hormone Therapy for Postmenopausal Women With ER+ Clinical Stage T2-4 TumorsCompletedNCT01831076Phase 2Results posted
• Phase III Study to Evaluate Morning Testosterone Normalization in Overweight Men With Secondary HypogonadismCompletedNCT01739595Phase 3Results posted
• Preoperative Window of Endocrine Therapy Provides Information to Increase ComplianceCompletedNCT01614210Phase 2Results posted
• Efficacy Study of Raloxifene to Induce Ovulation in Polycystic Ovarian SyndromeTerminatedNCT01607320Not applicableResults posted
• Safety Study of Enclomiphene Citrate in the Treatment of Men With Secondary HypogonadismCompletedNCT01534208Phase 3Results posted
• Phase III Study to Evaluated Morning Testosterone Normalization in Men With Secondary HypogonadismCompletedNCT01532414Phase 3Results posted
• The Effect on Androxal Versus Androgel on Morning Testosterone in Men With Secondary Hypogonadism (Low Testosterone)CompletedNCT01386606Phase 2Results posted
• Hormone Therapy Or Chemotherapy Before Surgery Based on Gene Expression Analysis in Treating Patients With Breast CancerCompletedNCT01293032Not applicableResults posted
• Differential Effects of Clomiphene Citrate in Women Undergoing SuperovulationCompletedNCT01291056Not applicableResults posted
• Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast CancerActive, not recruitingNCT01272037Phase 3Results posted
• Normalization of Morning Testosterone Levels in Men With Secondary HypogonadismCompletedNCT01270841Phase 2Results posted
• Safety and Efficacy Study of Creatine and Tamoxifen in Volunteers With Amyotrophic Lateral Sclerosis (ALS)CompletedNCT01257581Phase 2Results posted
• Low-Dose Tamoxifen Citrate in Reducing Breast Cancer Risk in Radiation-Induced Cancer SurvivorsActive, not recruitingNCT01196936Phase 2Results posted
• Re-expression of ER in Triple Negative Breast CancersTerminatedNCT01194908Phase 1/2Results posted
• A Study of Vorinostat and Tamoxifen in Newly Diagnosed Breast CancerTerminatedNCT01194427Phase 2Results posted
• Study to Evaluate the Efficacy of Androxal in Controlling Blood Glucose in Men With Type-2 Diabetes MellitusCompletedNCT01191320Phase 2Results posted
• Open-Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Tamoxifen When Coadministered To Healthy Post-Menopausal Female SubjectsCompletedNCT01189500Phase 4Results posted
• Enhancing Osteoporosis Therapy: Can We Open the Anabolic Window?CompletedNCT01166958Phase 4Results posted
• Hypogonadism in Young Men With Type 2 DiabetesTerminatedNCT01155518Phase 2Results posted
• Tamoxifen Citrate in Treating Patients With Metastatic or Recurrent Breast CancerCompletedNCT01124695Phase 2Results posted

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