Protein Kinase Inhibitors: all 15,147 studies that test it

Page 33 of 152. Open to participants first (2,533), then studies with results posted, then the rest; newest registration first within each.

• Study to Evaluate the Efficacy and Safety of Selonsertib in Participants With Moderate to Advanced Diabetic Kidney DiseaseCompletedNCT04026165Phase 2Results posted
• A Study of TAS-120 in Patients With Metastatic Breast CancerTerminatedNCT04024436Phase 2Results posted
• Neoadjuvant Cabozantinib in Treating Patients With Locally Advanced Kidney CancerActive, not recruitingNCT04022343Phase 2Results posted
• Study to Assess the Efficacy and Safety of Ublituximab and Umbralisib in Participants With Chronic Lymphocytic Leukemia (CLL) Currently Treated With Ibrutinib, Acalabrutinib or VenetoclaxTerminatedNCT04016805Phase 2Results posted
• A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of PF-06651600 in Subjects With Hepatic Impairment and Healthy VolunteersCompletedNCT04016077Phase 1Results posted
• Anlotinib Hydrochloride Combined With AP in Stage IIIB/IIIC/IV Non-squamous Non-small-cell Lung CancerCompletedNCT04012619Phase 1Results posted
• Acalabrutinib Safety Study in Untreated and Relapsed or Refractory Chronic Lymphocytic Leukemia PatientsCompletedNCT04008706Phase 3Results posted
• Long-Term PF-06651600 for the Treatment of Alopecia AreataCompletedNCT04006457Phase 3Results posted
• Evaluation of Safety, Tolerability, and Changes in Biomarker and Clinical Outcome Assessments of Losmapimod for FSHD1 With ExtensionTerminatedNCT04004000Phase 2Results posted
• Efficacy and Safety of Losmapimod in Subjects With Facioscapulohumeral Muscular Dystrophy (FSHD)CompletedNCT04003974Phase 2Results posted
• A Study to Evaluate Abemaciclib in Advanced Biliary Tract CarcinomaTerminatedNCT04003896Phase 2Results posted
• Efficacy and Safety of Pemigatinib in Participants With Solid Tumors With FGFR Mutations or Translocations (FIGHT-208)TerminatedNCT04003623Phase 2Results posted
• Pemigatinib + Pembrolizumab vs Pemigatinib Alone vs Standard of Care for Urothelial Carcinoma (FIGHT-205)TerminatedNCT04003610Phase 2Results posted
• Impact of Nilotinib on Safety, Tolerability, Pharmacokinetics and Biomarkers in Dementia With Lewy BodiesCompletedNCT04002674Phase 2Results posted
• Cognitive Effects of Oral p38 Alpha Kinase Inhibitor Neflamapimod in Dementia With Lewy BodiesCompletedNCT04001517Phase 2Results posted
• Erdafitinib and Abiraterone Acetate or Enzalutamide in Treating Patients With Double Negative Prostate CancerTerminatedNCT03999515Phase 2Results posted
• Imatinib for Pain in Sickle Cell AnemiaTerminatedNCT03997903Phase 1/2Results posted
• Abemaciclib and Pembrolizumab in Locally Advanced Unresectable or Metastatic Gastroesophageal Adenocarcinoma: Big Ten Cancer Research Consortium BTCRC-GI18-149TerminatedNCT03997448Phase 2Results posted
• Long Term Safety and Efficacy Study of Tolebrutinib (SAR442168) in Participants With Relapsing Multiple SclerosisCompletedNCT03996291Phase 2Results posted
• Axitinib and Avelumab in Treating Patients With Recurrent or Metastatic Adenoid Cystic CarcinomaCompletedNCT03990571Phase 2Results posted
• Dose-Esc/Exp RMC4630 & Cobi in Relapsed/Refractory Solid Tumors & RMC4630& Osi in EGFR+ Locally Adv/Meta NSCLCCompletedNCT03989115Phase 1/2Results posted
• Binimetinib and Palbociclib or TAS-102 in Treating Patients With KRAS and NRAS Mutant Metastatic or Unresectable Colorectal CancerCompletedNCT03981614Phase 2Results posted
• Within Subject Crossover Study of Cognitive Effects of Neflamapimod in Early-Stage Huntington DiseaseTerminatedNCT03980938Phase 2Results posted
• Safety and Efficacy of Itacitinib in Participants With Bronchiolitis Obliterans Syndrome Following Lung TransplantationTerminatedNCT03978637Phase 1/2Results posted
• A Study to Investigate the Safety and Efficacy of Elsubrutinib and Upadacitinib Given Alone or in Combination in Participants With Moderately to Severely Active Systemic Lupus Erythematosus (SLE)CompletedNCT03978520Phase 2Results posted
• Efficacy and Safety of Pembrolizumab (MK-3475) With Lenvatinib (E7080/MK-7902) vs. Docetaxel in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) and Progressive Disease (PD) After Platinum Doublet Chemotherapy and Immunotherapy (MK-7902-008/E7080-G000-316/LEAP-008)CompletedNCT03976375Phase 3Results posted
• A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast CancerActive, not recruitingNCT03975647Phase 3Results posted
• Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)Active, not recruitingNCT03974022Phase 1/2Results posted
• Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGGTerminatedNCT03973918Phase 2Results posted
• Abemaciclib in Patients With OligodendrogliomaCompletedNCT03969706Phase 2Results posted
• Study of Alvocidib in Patients With Relapsed/Refractory AML Following Treatment With Venetoclax Combination TherapyTerminatedNCT03969420Phase 2Results posted
• Investigate the Influence of Severe Hepatic Impairment on the Pharmacokinetics of Acalabrutinib and Its MetaboliteCompletedNCT03968848Phase 1Results posted
• Immediate Prostatectomy vs. Cabozantinib Followed by Prostatectomy in Men With High-Risk Prostate CancerTerminatedNCT03964337Phase 2Results posted
• A Study to Evaluate the Efficacy and Safety of PF-06700841 in Subjects With Active Psoriatic ArthritisCompletedNCT03963401Phase 2Results posted
• MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform NeurofibromasActive, not recruitingNCT03962543Phase 2Results posted
• Intermittent Duvelisib Dosing in Treating Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaActive, not recruitingNCT03961672Phase 2Results posted
• A Performance and Bioavailability Study of Entrectinib in Healthy Volunteers.CompletedNCT03961100Phase 1Results posted
• Efficacy and Safety of Delgocitinib Cream in Discoid Lupus Erythematosus.TerminatedNCT03958955Phase 2Results posted
• Cabozantinib and Pembrolizumab for Advanced Metastatic MelanomaTerminatedNCT03957551Phase 1/2Results posted
• Study of the Safety and Efficacy of Ruxolitinib Cream for Non-Sclerotic Chronic Cutaneous Graft-Versus-Host DiseaseActive, not recruitingNCT03954236Phase 2Results posted
• A Depot Formulation of Sunitinib Malate (GB-102) Compared to Aflibercept in Subjects With Wet AMDCompletedNCT03953079Phase 2Results posted
• A Study of Baricitinib (LY3009104) in Children and Adolescents With Atopic DermatitisCompletedNCT03952559Phase 3Results posted
• An Efficacy and Safety Study of Fedratinib Compared to Best Available Therapy in Subjects With DIPSS-intermediate or High-risk Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocythemia Myelofibrosis and Previously Treated With RuxolitinibCompletedNCT03952039Phase 3Results posted
• Study of Cabozantinib as 2nd Line Treatment in Subjects With Locally Advanced or Metastatic Renal Cell Carcinoma (RCC) With a Clear-Cell Component Who Progressed After 1st Line Treatment With Checkpoint InhibitorsCompletedNCT03945773Phase 2Results posted
• Study of Efficacy and Safety of LOU064 in Inadequately Controlled Asthma PatientsTerminatedNCT03944707Phase 2Results posted
• An Investigational Study to Evaluate the Safety and Effectiveness of BMS-986165 With Background Treatment in Participants With Lupus NephritisTerminatedNCT03943147Phase 2Results posted
• Efficacy and Tolerability Study of Two Dosing Regimens of CTP-543 in Adults With Alopecia AreataCompletedNCT03941548Phase 2Results posted
• A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2)CompletedNCT03940703Phase 2Results posted
• Testing the Addition of Copanlisib to Usual Treatment (Fulvestrant and Abemaciclib) in Metastatic Breast CancerActive, not recruitingNCT03939897Phase 1Results posted
• Study of Cabozantinib in Combination With Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Renal Cell CarcinomaActive, not recruitingNCT03937219Phase 3Results posted
• Safety and Efficacy of Deucravacitinib in Participants With Moderate to Severe Ulcerative ColitisCompletedNCT03934216Phase 2Results posted
• Sirolimus in Previously Treated Idiopathic Multicentric Castleman DiseaseActive, not recruitingNCT03933904Phase 2Results posted
• Study of Acalabrutinib in Chinese Adult Subjects With Relapsed or Refractory Mantle Cell Lymphoma, Chronic Lymphocytic Leukemia or Other B-cell MalignanciesActive, not recruitingNCT03932331Phase 1/2Results posted
• A Study to Evaluate Drug-Drug Interaction of TAK-788 With Itraconazole and Rifampin in Healthy Adult ParticipantsCompletedNCT03928327Phase 1Results posted
• This Was a Dose-finding Study to Evaluate Efficacy and Safety of LOU064 in Patients With CSU Inadequately Controlled by H1-antihistaminesCompletedNCT03926611Phase 2Results posted
• Study to Evaluate the Effect of Filgotinib on Semen Parameters in Adult Males With Active Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, or Non-radiographic Axial SpondyloarthritisCompletedNCT03926195Phase 2Results posted
• An Investigational Study to Evaluate Experimental Medication BMS-986165 in Japanese Participants With Moderate-to-Severe PsoriasisCompletedNCT03924427Phase 3Results posted
• Study of NMS-03592088 in Patients With Relapsed or Refractory AML or CMMLTerminatedNCT03922100Phase 1/2Results posted
• JAK Inhibitor Treatment in AGSCompletedNCT03921554Phase 2Results posted
• Long-Term Safety and Efficacy Study of Deucravacitinib in Participants With Systemic Lupus ErythematosusCompletedNCT03920267Phase 2Results posted
• TD-1473 Long-Term Safety (LTS) Ulcerative Colitis (UC) StudyTerminatedNCT03920254Phase 2/3Results posted
• KD025 in Subjects With Diffuse Cutaneous Systemic SclerosisTerminatedNCT03919799Phase 2Results posted
• Umbralisib and Rituximab as Initial Therapy for Patients With Follicular Lymphoma and Marginal Zone LymphomaTerminatedNCT03919175Phase 2Results posted
• A Study of Baricitinib (LY3009104) in Participants With Rheumatoid ArthritisCompletedNCT03915964Phase 4Results posted
• An Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung CancerCompletedNCT03915951Phase 2Results posted
• Study Evaluating the Mechanism of Action of PF-04965842 Monotherapy for Moderate-to-severe Atopic DermatitisCompletedNCT03915496Phase 2Results posted
• Testing the Combination of Cabozantinib, Nivolumab, and Ipilimumab (CaboNivoIpi) for Advanced Differentiated Thyroid CancerActive, not recruitingNCT03914300Phase 2Results posted
• An Open-Label, Randomized, Multicenter Trial of Encorafenib + Binimetinib Evaluating a Standard-dose and a High-dose Regimen in Patients With BRAFV600-mutant Melanoma Brain MetastasisTerminatedNCT03911869Phase 2Results posted
• A Study of Lorlatinib in ALK Inhibitor-Treated ALK-Positive NSCLC in ChinaCompletedNCT03909971Phase 2Results posted
• Human Absorption, Distribution and Metabolism Study (hAME) [14C]-KD025CompletedNCT03907540Phase 1Results posted
• Phase 3 Study of Sitravatinib Plus Nivolumab vs Docetaxel in Patients With Advanced Non-Squamous Non-Small Cell Lung CancerTerminatedNCT03906071Phase 3Results posted
• Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have SurgeryTerminatedNCT03904862Phase 1/2Results posted
• Dose Ranging Study to Assess Efficacy, Safety, Tolerability and Pharmacokinetics of PF-06700841 Topical Cream in Participants With Mild or Moderate Atopic DermatitisCompletedNCT03903822Phase 2Results posted
• Effect of Low-Fat Food on Pexidartinib Pharmacokinetics in Healthy VolunteersCompletedNCT03901313Phase 1Results posted
• A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) TumorsActive, not recruitingNCT03899792Phase 1/2Results posted
• A Study of Baricitinib (LY3009104) in Adults With Severe or Very Severe Alopecia AreataCompletedNCT03899259Phase 3Results posted
• Encorafenib and Binimetinib Before Local Treatment in Patients With BRAF Mutant Melanoma Metastatic to the BrainCompletedNCT03898908Phase 2Results posted
• Study of First-line Pembrolizumab (MK-3475) With Lenvatinib (MK-7902/E7080) in Urothelial Carcinoma Cisplatin-ineligible Participants Whose Tumors Express Programmed Cell Death-Ligand 1 and in Participants Ineligible for Platinum-containing Chemotherapy (MK-7902-011/E7080-G000-317/ LEAP-011)CompletedNCT03898180Phase 3Results posted
• Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC)CompletedNCT03897036Phase 1Results posted
• Randomized Trial of Topotecan With M6620, an ATR Kinase Inhibitor, in Small Cell Lung Cancers and Small Cell Cancers Outside of the LungsActive, not recruitingNCT03896503Phase 2Results posted
• A Study to Evaluate Safety and Efficacy of PF-06826647 For Moderate To Severe Plaque PsoriasisCompletedNCT03895372Phase 2Results posted
• A Clinical Study of Regorafenib in Participants Who Have Been Treated in Previous Bayer-sponsored Regorafenib Studies That Have Been CompletedCompletedNCT03890731Phase 2Results posted
• Idelalisib+Obinutuzumab in Patients With Relapsed/Refractory Follicular LymphomaTerminatedNCT03890289Phase 2Results posted
• Study to Evaluate the Safety and Efficacy of SDP-4 in Subjects With Dry Eye Disease (DED)CompletedNCT03889886Phase 2Results posted
• Dose-finding Study for SAR442168 in Relapsing Multiple SclerosisCompletedNCT03889639Phase 2Results posted
• Impact of Bosutinib on Safety, Tolerability, Biomarkers and Clinical Outcomes in Dementia With Lewy BodiesCompletedNCT03888222Phase 2Results posted
• Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Versus Chemotherapy for Endometrial Carcinoma (ENGOT-en9 / MK-7902-001)CompletedNCT03884101Phase 3Results posted
• Efficacy and Safety of BMS-986165 Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA)CompletedNCT03881059Phase 2Results posted
• Testing the Effect of Taking Ruxolitinib and CPX-351 in Combination for the Treatment of Advanced Phase Myeloproliferative NeoplasmsTerminatedNCT03878199Phase 1/2Results posted
• Testing Olaparib and AZD6738 in IDH1 and IDH2 Mutant TumorsActive, not recruitingNCT03878095Phase 2Results posted
• A Study of Copanlisib and Ibrutinib in Mantle Cell LymphomaCompletedNCT03877055Phase 1/2Results posted
• Safety, Tolerability and Pharmacokinetics (PKs) Investigation of GSK3186899 in Healthy SubjectsTerminatedNCT03874234Phase 1Results posted
• A Study Evaluating the Efficacy of Venetoclax Plus Ibrutinib in Participants With T-cell Prolymphocytic LeukemiaCompletedNCT03873493Phase 2Results posted
• Evaluate Severe Hepatic Impairment on Dacomitinib PKCompletedNCT03865446Phase 1Results posted
• Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid TumorsCompletedNCT03864042Phase 1Results posted
• Osimertinib Study in Indian PatientsCompletedNCT03853551Phase 4Results posted
• Dose Ranging Study To Assess Efficacy, Safety and Tolerability Of PF-06700841 Topical Cream In PsoriasisCompletedNCT03850483Phase 2Results posted
• A Study to Evaluate Safety and Efficacy of HS-10296 as First-Line Treatment in PatientsStatus unknownNCT03849768Phase 3Results posted
• Itacitinib for Low Risk GVHDCompletedNCT03846479Phase 2Results posted
• Study of Zanubrutinib (BGB-3111) in Participants With Marginal Zone LymphomaCompletedNCT03846427Phase 2Results posted

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