Protein Kinase Inhibitors: all 15,147 studies that test it
Page 126 of 152. Open to participants first (2,533), then studies with results posted, then the rest; newest registration first within each.
- A Study of LY2784544 in Participants With Myeloproliferative NeoplasmsActive, not recruitingNCT01594723Phase 2
- A Prospective, Open Label Study of CERtican in KIdney TransplantationCompletedNCT01594268Phase 4
- CAEB071 Thorough QTc Study in Healthy VolunteersCompletedNCT01594255Phase 1
- Dual Blockage With Afatinib and Trastuzumab as Neoadjuvant Treatment for Patients With Locally Advanced or Operable Breast Cancer Receiving Taxane-anthracycline Containing ChemotherapyCompletedNCT01594177Phase 2
- Study to Evaluate Safety and Immunologic Biomarker of Rapamune in Patients With Stable Renal Transplant RecipientStatus unknownNCT01592253Not applicable
- P13Kinase Inhibitor BKM120 in Combination With Panitumumab in Metastatic/Advanced RAS-Wild Type Colorectal Cancer.CompletedNCT01591421Phase 1/2
- 24-week Study With Open Label Extension of VX-509, an Oral JAK3 Inhibitor, in Subjects Taking MethotrexateCompletedNCT01590459Phase 2
- Evaluate Safety and Tolerability of Pasireotide LAR in Combination With Everolimus in Advanced Metastatic NETsCompletedNCT01590199Phase 1
- Safety and Efficacy of BKM120 and Lapatinib in HER2+/PI3K-activated, Trastuzumab-resistant Advanced Breast CancerTerminatedNCT01589861Phase 1/2
- A Open-Label, Multiple Ascending Dose Study of DS-3078a, an Oral TORC1/2 Kinase Inhibitor, in Subjects With Advanced Solid Tumors or LymphomasCompletedNCT01588678Phase 1
- Phase I/II Trial to Evaluate Safety, Tolerability and Pharmacokinetic Profile of HM61713 in NSCLC PatientsCompletedNCT01588145Phase 1/2
- Safety, Pharmacokinetics, Pharmacodynamics and Anti-tumor Activity of Sorafenib and Eribulin in CombinationCompletedNCT01585870Phase 1
- Phase I Study of AT13148, a Novel AGC Kinase InhibitorCompletedNCT01585701Phase 1
- Drug Interaction Study of SAR302503 in Patients With Solid TumorCompletedNCT01585623Phase 1
- Vemurafenib and White Blood Cell Therapy for Advanced MelanomaTerminatedNCT01585415Phase 1
- Asian Subjects With Metastatic Colorectal Cancer Treated With Regorafenib or Placebo After Failure of Standard TherapyCompletedNCT01584830Phase 3
- Vargatef in Addition to First Line Chemotherapy With Interval Debulking Surgery in Patients With Ovarian CancerCompletedNCT01583322Phase 2
- A Phase I Study to Investigate the Safety, Tolerability and Pharmacokinetic Profile of of GSK2118436 in Japanese Subjects With BRAF Mutation Positive Solid TumorsCompletedNCT01582997Phase 1
- XL184 For Relapsed/Refractory Multiple Myeloma (MM) With Bone DiseaseCompletedNCT01582295Phase 1
- Phase I/II Dose-escalation Study to Investigate Safety and Pharmacokinetics/ Pharmacodynamics of WX-554 in Patients With Solid TumoursTerminatedNCT01581060Phase 1/2
- ARQ 197 Plus Erlotinib in Patient With Locally Advanced or Metastatic EGFR Mutation-positive Non-small-cell Lung CancerCompletedNCT01580735Phase 2
- A Phase 3 Study Comparing Dinaciclib Versus Ofatumumab in Patients With Refractory Chronic Lymphocytic Leukemia (P07714)CompletedNCT01580228Phase 3
- Validation of Digital-PCR Analysis Through Programmed Imatinib Interruption in PCR Negative CML PatientsCompletedNCT01578213Phase 4
- Sorafenib Tosylate Before and After Donor Bone Marrow Transplant in Treating Patients With Acute Myeloid LeukemiaCompletedNCT01578109Phase 1
- Pazopanib in Second-line Therapy in Renal Cell CarcinomaStatus unknownNCT01577784Phase 2
- Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid TumorsCompletedNCT01576666Phase 1
- Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of PregnancyCompletedNCT01576458Phase 3
- A Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Advanced Scirrhous Gastric Carcinoma PatientsCompletedNCT01576380Phase 2
- XL-184+Abiraterone in Post-Chemo CRPCCompletedNCT01574937Phase 1
- Clinical Study to Evaluate the Maximum Tolerated Dose of BAY1000394 When Given Together With Chemotherapy and the Effectiveness of This Combination Treatment in Shrinking a Specific Type of Lung Tumors (Small Cell Lung Cancer)TerminatedNCT01573338Phase 1/2
- Safety Study of AKN-028 in Patients With Acute Myelogenous LeukemiaTerminatedNCT01573247Phase 1/2
- A Study To Compare Pharmacokinetics Of Dacomitinib (PF-00299804) Between Healthy Subjects And Subjects With Mild And Moderate Hepatic ImpairmentCompletedNCT01571388Phase 1
- BKM120 + mFOLFOX6 in Advanced Solid Tumors With Expansion Cohort Pancreatic CancerCompletedNCT01571024Phase 1
- A Trial of Gefitinib in Combination With BKM120 in Patients With Advanced Non-Small Cell Lung Cancer, With Enrichment for Patients Whose Tumours Harbour Molecular Alterations of PI3K Pathway and Known to Overexpress EGFRCompletedNCT01570296Phase 1
- Safety, Tolerability and PK of a Single iv Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy VolunteersCompletedNCT01570205Phase 1
- Imatinib and Carvedilol for High Blood Pressure in the Lungs in Adults With Sickle Cell DiseaseWithdrawnNCT01568645Phase 1
- Temsirolimus as Second-line Therapy in HCCStatus unknownNCT01567930Phase 2
- Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell LymphomaCompletedNCT01567709Phase 1
- Phase II Study of Everolimus Combined With Octreotide LAR to Treat Advanced GI NETCompletedNCT01567488Phase 2
- The Combination of Rad001 and Rituximab In Patients With Non-hodgkin's LymphomasCompletedNCT01567475Phase 1
- A Phase I Study of OSI-906 in Combination With Pemetrexed in Advanced Solid Tumor MalignanciesWithdrawnNCT01567384Phase 1
- Second-line Pazopanib Renal Cell Carcinoma (RCC) Study. CTRIAL-IE (ICORG) 10-01, V5CompletedNCT01566747Phase 2
- A Study to Identify a Biomarker Predictive for Response on Everolimus in Solid Tumors (CPCT-03)CompletedNCT01566279Not applicable
- A Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid ArthritisCompletedNCT01565655Phase 2
- A Study of GDC-0575 Alone and in Combination With Gemcitabine in Participants With Refractory Solid Tumors or LymphomaCompletedNCT01564251Phase 1
- A Study of MEK162 and AMG 479 in Patients With Selected Solid TumorsTerminatedNCT01562899Phase 1/2
- A Randomized Phase II Clinical Trial on the Efficacy of Axitinib as a Monotherapy or in Combination With Lomustine for the Treatment of Patients With Recurrent GlioblastomaCompletedNCT01562197Phase 2
- Study in Healthy Volunteers to Assess the Pharmacokinetics (PK) of Digoxin Administered Alone and in Combination With VandetanibCompletedNCT01561781Phase 1
- Study of AXL1717 Compared to Docetaxel to Treat Squamous Cell Carcinoma or Adenocarcinoma of the LungCompletedNCT01561456Phase 2
- Effect of the Inhibition of the Mammalian Target of Rapamycin on Metabolism and ExerciseTerminatedNCT01561404Phase 4
- Oxaliplatin, Fluorouracil, Erlotinib Hydrochloride, and Radiation Therapy Before Surgery and Erlotinib Hydrochloride After Surgery in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal JunctionCompletedNCT01561014Phase 1
- Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MEK162 in Noonan Syndrome Hypertrophic CardiomyopathyWithdrawnNCT01556568Phase 2
- Lung Cancer in Women Treated With Anti-oestrogens anD Inhibitors of EGFRCompletedNCT01556191Phase 2
- A Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid Arthritis Subjects Who Have Had an Inadequate Response to MethotrexateCompletedNCT01554696Phase 2
- Afatinib With CT and RT for EGFR-Mutant NSCLCActive, not recruitingNCT01553942Phase 2
- Dose-Finding Study of Cabozantinib (XL184) in Japanese Subjects With Advanced CancerCompletedNCT01553656Phase 1
- Pazopanib Hydrochloride in Treating Patients With Advanced or Refractory Solid TumorsActive, not recruitingNCT01552356Phase 1
- A Phase I Study to Assess the Pharmacokinetics of Metformin When Administered Alone and in Combination With VandetanibCompletedNCT01551615Phase 1
- A Phase II Study of Sunitinib Versus Dacarbazine in the Treatment of Patients With Metastatic Uveal MelanomaCompletedNCT01551459Phase 2
- BKM120 in Advanced, Metastatic, or Recurrent Endometrial CancersWithdrawnNCT01550380Phase 2
- Drug Drug Interaction Study Of Crizotinib With Esomeprazole.CompletedNCT01549574Phase 1
- IPI-145 Single Ascending, Multiple Ascending, Food Effect and Drug-Drug-Interaction StudyCompletedNCT01549106Phase 1
- Determination of Dose of Antiangiogenic Multitargeted DOVITINIB (TKI258) Plus Paclitaxel in Patients With Solid TumorsTerminatedNCT01548924Phase 1
- Phase 1 Trial of the Mammalian Target of Rapamycin (mTOR) Inhibitor Everolimus Plus Radiation Therapy (RT) for Salvage Treatment of Biochemical Recurrence in Prostate Cancer Patients Following ProstatectomyCompletedNCT01548807Phase 1
- Trebananib And Temsirolimus in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by SurgeryCompletedNCT01548482Phase 1
- To Assess the Interaction Between Sunitinib and Ketoconazole to Reduce the Dose and Cost of SunitinibCompletedNCT01548170Phase 1
- Pazopanib or Pemetrexed and Crizotinib in Advanced CancerTerminatedNCT01548144Phase 1
- Ursodeoxycholic Acid in Bariatric SurgeryCompletedNCT01548079Not applicable
- A Study of GDC-0084 in Patients With Progressive or Recurrent High-Grade GliomaCompletedNCT01547546Phase 1
- A Phase I Study of INC280 in Japanese Patients With Advanced Solid TumorsCompletedNCT01546428Phase 1
- Study Assessing Safety, Pharmacokinetics and Efficacy of CC-223 With Either Erlotinib or Oral Azacitidine in Advanced Non-Small Cell Lung CancerCompletedNCT01545947Phase 1
- Proof of Concept Trial of Gleevec (Imatinib) in Active Diffuse SclerodermaTerminatedNCT01545427Phase 2
- Dose Escalation Study of the Safety and Pharmacokinetics of ME-344 Single Agent for Refractory Solid TumorsCompletedNCT01544322Phase 1
- Study in Healthy Volunteers to Assess the Pharmacokinetics of Midazolam Administered Alone and in Combination With VandetanibCompletedNCT01544140Phase 1
- Study of Preoperative Therapy With Pazopanib (Votrient®) to Treat High-risk Soft Tissue SarcomaTerminatedNCT01543802Phase 2
- Treatment With BIBW 2992, Irreversible Inhibitor of EGFR and HER-2 in Non-small Cell Lung CancerCompletedNCT01542437Phase 2
- A Combination of Pazopanib and Carboplatin in Advanced Solid MalignanciesTerminatedNCT01542047Phase 1
- Losmapimod in Chronic Obstructive Pulmonary Disease Patients Stratified by Fibrinogen.CompletedNCT01541852Phase 2
- Imatinib Dose Escalation to 800 mg/Day in Korean Patients With Metastatic or Unresectable GIST Harboring KIT Exon 9 Mutation: KENEDIActive, not recruitingNCT01541709Phase 2
- MLN8237 in Head and Neck CancerCompletedNCT01540682Phase 1
- Pharmacodynamic Study With FLT-PET/CT in Patients With Prostate/Other Solid Malignancies Treated With High Dose AxitinibCompletedNCT01540526Phase 1
- Determine the Pharmacokinetics and Safety of Brivanib in Chinese Subjects With Advanced Primary Liver Cancer (Hepatocellular Carcinoma: HCC)CompletedNCT01540461Phase 1
- PI3K Inhibitor BKM120 and Docetaxel in Treating Patients With Advanced Solid Tumor That is Locally Advanced, Cannot Be Removed By Surgery, or MetastaticCompletedNCT01540253Phase 1
- Study in Healthy Volunteers to Assess Effect of Omeprazole and Ranitidine on the Pharmacokinetics of VandetanibCompletedNCT01539655Phase 1
- Sorafenib Plus Tegafur-uracil (UFT) Versus Sorafenib as First Line Systemic Treatment for Patients With Advanced Stage HCC, Unresectable & Not Eligible for Local Ablation and/or TACETerminatedNCT01539018Phase 2
- Neoadjuvant Afatinib Window Study in Squamous Cell Carcinoma of the Head and NeckCompletedNCT01538381Phase 2
- pazopanib_NCRCC,Ph2 STUDYCompletedNCT01538238Phase 2
- Sirolimus and Vismodegib in Treating Patients With Solid Tumors or Pancreatic Cancer That is Metastatic or Cannot Be Removed By SurgeryCompletedNCT01537107Phase 1
- A Open Label Study of the Efficacy and Safety of PD0332991 a Selective Inhibitor of the Cyclin Dependent Kinases 4 and 6 in Patients With Recurrent Ovarian Cancer Demonstrating Rb-proficiency and Low p16 ExpressionCompletedNCT01536743Phase 2
- Sirolimus and Vaccine Therapy in Treating Patients With Stage II-IV Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity CancerCompletedNCT01536054Phase 1
- Study of Inotuzumab Ozogamicin + Temsirolimus in Patients With Relapsed or Refractory CD22+ B-cell NHLymphomaCompletedNCT01535989Phase 1
- Nilotinib in PH+, BCR-, ABL+ CML PatientsCompletedNCT01535391Phase 3
- Safety and Efficacy Study of Icotinib With Intensity-modulated Radiotherapy in Nasopharyngeal CarcinomaCompletedNCT01534585Phase 1/2
- Erlotinib in Combination With Pralatrexate in Advanced MalignanciesCompletedNCT01532011Phase 1
- Dose Finding and Pharmacokinetics/Pharmacodynamics Study of Apatinib in the Treatment of Advanced Colorectal CancerCompletedNCT01531777Phase 2
- BIBW 2992 (Afatinib) and VinorelbineTerminatedNCT01531764Phase 2
- Study of Neoadjuvant Treatment in Patients With Pancreatic Cancer That is Potentially ResectableTerminatedNCT01531712Phase 2
- Vemurafenib With Sorafenib Tosylate or Crizotinib in Treating Patients With Advanced Malignancies With BRAF MutationsCompletedNCT01531361Phase 1
- A Study to Look at How a Single Oral Dose of 14C-OSI-906 is Absorbed, Broken Down and Eliminated in the BodyCompletedNCT01529684Phase 1
- Temsirolimus in Combination With Metformin in Patients With Advanced CancersTerminatedNCT01529593Phase 1