Pemetrexed: all 524 studies that test it

Page 3 of 6. Open to participants first (73), then studies with results posted, then the rest; newest registration first within each.

• A Trial for Patients With Advanced/Recurrent Endometrial CancerCompletedNCT00377520Phase 2Results posted
• Pemetrexed Plus Cisplatin Bi-Weekly, in Patients With Urothelial Cancer (Metastatic, Locally Advanced or Non-Resectable)CompletedNCT00374868Phase 1/2Results posted
• Dosage Schedule Study of Pemetrexed Monochemotherapy for Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)CompletedNCT00370292Phase 2Results posted
• Gemcitabine and Pemetrexed Disodium in Treating Patients With Advanced Mycosis Fungoides or Sézary SyndromeTerminatedNCT00369629Phase 1Results posted
• Study of Pemetrexed and Carboplatin Compared With Etoposide Carboplatin to Treat Extensive-Stage Small Cell Lung CancerCompletedNCT00363415Phase 3Results posted
• Chemotherapy Treatment in Re-occurring Non Small Cell Lung Cancer (NSCLC) After Previous Chemotherapy and Surgical Removal of the NSCLC TumorTerminatedNCT00356525Phase 2Results posted
• Phase I/II Trial of Bevacizumab, Pemetrexed and Erlotinib in Elderly Patients With Non-Small Cell Lung CancerTerminatedNCT00351039Phase 1/2Results posted
• Pemetrexed/Carboplatin Non-Small Cell Lung Cancer (NSCLC) Elderly PatientsCompletedNCT00350792Phase 2Results posted
• A Study of Pemetrexed and Folic Acid Given Before Surgery (Neoadjuvant Treatment) to Patients With Rectal Cancer.CompletedNCT00330915Phase 2Results posted
• Pemetrexed-Carboplatin and Gemcitabine-Vinorelbine in Advanced Breast CancerCompletedNCT00325234Phase 2Results posted
• Study of Pemetrexed Plus Cisplatin in Advanced Gastric CancerCompletedNCT00320515Phase 1/2Results posted
• Study of Pemetrexed in Mesothelioma and Lung Cancer Patients With Fluid Around the Lungs or AbdomenCompletedNCT00316225Phase 2Results posted
• Pemetrexed, Gemcitabine, and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic CancerTerminatedNCT00310050Phase 1Results posted
• First Line Chemotherapy Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)CompletedNCT00308750Phase 2Results posted
• Cisplatin, Pemetrexed Disodium, and Radiation Therapy Followed by Docetaxel in Treating Patients With Stage III Non-Small Cell Lung CancerCompletedNCT00301808Phase 2Results posted
• Cisplatin, Pemetrexed and Bevacizumab for Untreated Malignant MesotheliomaCompletedNCT00295503Phase 2Results posted
• Pemetrexed Chemotherapy in Poor-Risk Patients With Advanced Head and Neck CancerCompletedNCT00293579Phase 2Results posted
• Whole-Brain Radiation Therapy and Pemetrexed in Treating Patients With Brain Metastases From Non-Small Cell Lung CancerTerminatedNCT00280748Phase 2Results posted
• Radiation Therapy, Pemetrexed Disodium, and Carboplatin in Treating Patients With Locally Advanced Esophageal Cancer That Can Be Removed By SurgeryTerminatedNCT00268437Phase 2Results posted
• S0526: Pemetrexed Disodium in Treating Patients With Stage III or Stage IV Non-Small Cell Lung CancerTerminatedNCT00265785Phase 2Results posted
• Pemetrexed and Cisplatin Treatment Before Surgery in Non Small Cell Lung CancerTerminatedNCT00259285Phase 2Results posted
• Pemetrexed Disodium and Cisplatin in Treating Patients Who Are Undergoing Surgery for Stage I, Stage II, or Stage III Non-Small Cell Lung CancerCompletedNCT00248495Phase 2Results posted
• Carboplatin, Pemetrexed Disodium, and Bevacizumab in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung CancerCompletedNCT00234052Phase 2Results posted
• Positron Emission Tomography in Predicting Response in Patients Who Are Undergoing Treatment With Pemetrexed Disodium and Cisplatin With or Without Surgery for Stage I, Stage II, or Stage III Non-Small Cell Lung CancerCompletedNCT00227539Phase 2Results posted
• Phase 2 Trial of Bevacizumab in Combination With PemetrexedCompletedNCT00227019Phase 2Results posted
• Pharmacogenomic & Phase II Study of Gemcitabine and Pemetrexed in Non-Small-Cell Lung Cancer.CompletedNCT00226577Phase 2Results posted
• Study of Pemetrexed and Bevacizumab in Patients With Head and Neck CancerCompletedNCT00222729Phase 2Results posted
• Pemetrexed Plus Cetuximab in Patients With Recurrent Non Small Cell Lung CancerCompletedNCT00216203Phase 1/2Results posted
• Pemetrexed as Second-Line Therapy in Treating Patients With Hormone Refractory Prostate CancerCompletedNCT00216099Phase 2Results posted
• Trial Comparing Cetuximab With Pemetrexed/Cetuximab Therapy for Non-Small Cell Lung CancerTerminatedNCT00203931Phase 2Results posted
• Phase II Study of Alimta (Pemetrexed) Treatment of Advanced Thymoma and Thymic CarcinomaCompletedNCT00198133Phase 2Results posted
• Pemetrexed and Gemcitabine in Patients With Advanced Non-Small Cell Lung CancerCompletedNCT00193414Phase 2Results posted
• A Study of the Combination of Pemetrexed and Irinotecan Every Two Weeks in Metastatic Colorectal CancerCompletedNCT00191984Phase 2Results posted
• Molecular Profiling in Lung Cancer PatientsCompletedNCT00191308Phase 2Results posted
• To Investigate Efficacy and Safety of Pemetrexed as Second or Third Line Therapy in Patients With Non-small Cell Lung Cancer (NSCLC)CompletedNCT00191191Phase 2Results posted
• A Trial for Patients With Advanced/Recurrent Cervical CancerCompletedNCT00190983Phase 2Results posted
• A Study of Pemetrexed and Cyclophosphamide Given Every 21 Days in Advanced Breast Cancer PatientsCompletedNCT00190671Phase 1/2Results posted
• Pleurectomy/Decortication With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Sodium ThiosulfateTerminatedNCT00165503Phase 2Results posted
• Preoperative Treatment of Breast Cancer With Two Different Sequential Treatment RegimensCompletedNCT00149214Phase 2Results posted
• Study of Pemetrexed and Gemcitabine for Patients With a New Diagnosis of Extensive-Stage Small Cell Lung CancerTerminatedNCT00129974Phase 2Results posted
• Pemetrexed as the First Treatment in Advanced or Metastatic Breast CancerCompletedNCT00106002Phase 2Results posted
• Pemetrexed and Best Supportive Care Versus Placebo and Best Supportive Care in Non-Small Cell Lung Cancer (NSCLC)CompletedNCT00102804Phase 3Results posted
• Docetaxel or Pemetrexed With or Without Cetuximab in Patients With Recurrent or Progressive Non-Small Cell Lung CancerCompletedNCT00095199Phase 3Results posted
• Phase II Trial of Neo-Adjuvant Pemetrexed Plus Cisplatin Followed by Surgery and Radiation for Pleural MesotheliomaCompletedNCT00087698Phase 2Results posted
• Pemetrexed Plus Gemcitabine in Metastatic Breast Cancer Patients After Receiving Taxane TherapyCompletedNCT00063570Phase 2Results posted
• Intrathecal Dual Checkpoint Inhibitor (PD-1 and CTLA-4) in Combination With Pemetrexed for Leptomeningeal MetastasisActive, not recruitingNCT06809530Phase 1/2
• Intrathecal Combination of Programmed Death-1 (PD-1)/Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Bispecific Antibody and Pemetrexed for Leptomeningeal MetastasisActive, not recruitingNCT06762080Phase 1/2
• Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung CancerActive, not recruitingNCT06632327Phase 3
• A Study to See How Well and How Safely Different Treatments Work in a Group of Participants With Non-Small Cell Lung Cancer (NSCLC)CompletedNCT06624059Phase 3
• Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid TumorsActive, not recruitingNCT06462222Phase 1/2
• A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung CancerActive, not recruitingNCT06417814Phase 3
• Neoadjuvant Lazertinib With or Without Chemotherapy for Patients With EGFR-mutated Resectable Non-small Cell Lung CancerActive, not recruitingNCT06268210Phase 2
• Study of Vudalimab or Pembrolizumab in Combination With Chemotherapy as First-line Treatment in Patients With Advanced NSCLCTerminatedNCT06173505Phase 1/2
• Study of Intravenous Telisotuzumab Vedotin in Combination Osimertinib or Standard of Care Chemotherapy to Assess Change in Disease Activity in Adult Participants With Non-Small Cell Lung Cancer That Has a Mutation in the Epidermal Growth Factor Receptor Gene and That Overexpresses the c-Met ProteinWithdrawnNCT06093503Phase 3
• Lazertinib+Pemetrexed/Carboplatin in Patients With EGFR Sensitizing Mutation Positive Recurrent or Metastatic Non-Small Cell Lung Cancer Failed to Prior LazertinibCompletedNCT05786430Phase 2
• Immune Profile Selection By Fraction of ctDNA in Patients With Advanced NSCLC Treated With ImmunotherapyTerminatedNCT05715229Phase 2
• Study of Novel Treatment Combinations in Patients With Lung CancerActive, not recruitingNCT05633667Phase 2
• Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C MutationActive, not recruitingNCT05609578Phase 2
• Indirect Pulp Capping Versus Pulpotomy With MTA for Treatment of Primary Molars With Deep CariesStatus unknownNCT05554952Not applicable
• Study of Osimertinib+Bevacizumab+Chemotherapy for EGFR+ Advanced Non-Small Cell Lung Cancer With Concurrent MutationsStatus unknownNCT05507606Phase 2
• Lazertinib/Pemetrexed/Carboplatin After Osimertinib Failure in NSCLC With Brain MetastasesTerminatedNCT05477615Phase 2
• Efficacy and Safety Evaluation of Percutaneous Ommaya Capsule Injection of Autologous Bi-dimensional Specific T Cells in the Treatment of Glioma and in Combination With Pemetrexed in the Treatment of Brain/Meningeal MetastasesStatus unknownNCT05459441Early Phase 1
• Clinical Assessment of 3 Differant Obturation Sealers on Postoprative Pain and SwellingStatus unknownNCT05419752Phase 2/3
• A Phase 2 Study to Evaluate the Triplet Combination of Pemetrexed Plus AB928 (Etrumadenant) + AB122 (Zimberelimab) in Patients With Previously Treated Advanced or Metastatic MTAP Deficient Urothelial CarcinomaActive, not recruitingNCT05335941Phase 2
• Amivantamab, Lazertinib, and Pemetrexed for First-line Treatment of Recurrent/Metastatic Non-small Cell Lung Cancers With Epidermal Growth Factor Receptor MutationsCompletedNCT05299125Phase 2
• Combining Afatinib and Concurrent Chemotherapy, Followed by Osimertinib and Concurrent Chemotherapy, in Untreated EGFR Positive NSCLC TumorsCompletedNCT05298176Phase 2
• Intrathecal Pemetrexed for Leptomeningeal MetastasisCompletedNCT05289908Phase 1/2
• Study of Chemotherapy and PD-1 Inhibitor Combination With Anti-angiogenesis to Treat Elderly Lung CancerStatus unknownNCT05273814Phase 1
• Lenvatinib in Combination With Carboplatin Pemetrexed and Pembrolizumab for NSCLC With EGFR MutationsCompletedNCT05258279Phase 2
• Relapsed or Refractory Primary Diffuse Large B-cell Lymphoma (DLBCL) of the Central Nervous System (CNS)Active, not recruitingNCT05253118Phase 2
• DPC in Primary Molars.CompletedNCT05222243Phase 4
• A Study to Evaluate the Efficacy and Safety of HLX07 in nsqNSCLC Patients With High EGFR ExpressionStatus unknownNCT05215925Phase 2
• Study of Safety and Efficacy of Brigatinib Plus Chemotherapy or Brigatinib Only in Advanced ALK-Positive Lung Cancer (MASTERPROTOCOL ALK)Active, not recruitingNCT05200481Phase 2
• A Study to Evaluate Nivolumab in Combination With Ipilimumab Versus Pemetrexed With Cisplatin or Carboplatin for Unresectable Pleural Mesothelioma in Chinese ParticipantsCompletedNCT05136677Phase 2
• A Study of SHR-1701 Plus Bevacizumab and Chemotherapy in Non-Small-Cell-Lung-CancerStatus unknownNCT05132413Phase 3
• A Phase II Study of Neoadjuvant Sotorasib in Combination With Cisplatin or Carboplatin and Pemetrexed for Surgically Resectable Stage IIA-IIIB Non-Squamous Non-Small Cell Lung Cancer With a KRAS p.G12C MutationActive, not recruitingNCT05118854Phase 2
• An Extension Study in Participants Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study (IMbrella C)Active, not recruitingNCT05112965Phase 3
• Surufatinib Combined With Toripalimab and Chemotherapy in the Treatment of Non-Small Cell Lung CancerActive, not recruitingNCT05003037Phase 2
• Camrelizumab Combined With Pemetrexed and Carboplatin for the Study of EGFR-mutated Lung Squamous NSCLC TreatmentStatus unknownNCT04970043Not applicable
• Monitoring the Efficacy of Duvalizumab Combined With Neoadjuvant Chemotherapy for Ib-IIIb NSCLC by Sequencing of Immune Receptor Repertoire: a Prospective, One Arm Clinical StudyStatus unknownNCT04897386Phase 2
• A Study of Sargramostim Plus Pembrolizumab with or Without Pemetrexed in Patients with Advance Non-small Cell Lung Cancer After Completion of ChemoimmunotherapyTerminatedNCT04856176Phase 2
• Ensartinib, Carboplatin, Pemetrexed and Bevacizumab for the Treatment of Stage IIIC or IV or Recurrent ALK-Positive Non-small Cell Lung CancerActive, not recruitingNCT04837716Phase 1
• Osimertinib Plus Chemotherapy vs Osimertinib in EGFRm NSCLC With Persistence Week-3 ctDNA EGFRm After 1L OsimertinibCompletedNCT04769388Phase 2
• Study of Pembrolizumab With Single Agent Chemotherapy in Elderly Patients With Advanced NSCLCWithdrawnNCT04754815Phase 2
• Osimertinib Monotherapy or Combination With Chemotherapy for Advanced NSCLC Concurrent EGFR and TP53 MutationsActive, not recruitingNCT04695925Phase 3
• Pemetrexed and TAS-102 in Combination With Bevacizumab in Refractory Colorectal CancerStatus unknownNCT04683965Phase 2
• A Study of AK104 in Patients With Locally Advanced or Metastatic Non-small Cell Lung CancerCompletedNCT04647344Phase 1/2
• A Study to Evaluate SHR-1210 in Combination With Famitinib Plus Chemotherapy in Subjects With NSCLC.TerminatedNCT04619433Phase 3
• Almonertinib/Pemetrexed/Carboplatin in EGFR T790M+ Advanced Lung CancerStatus unknownNCT04592666Phase 2
• Dynamic PET/CT Evaluated the Response of Neoadjuvant Anti-PD1 Combination With Chemotherapy for Ⅱa-Ⅲb NSCLCStatus unknownNCT04586465Phase 2
• Tislelizumab Combined With Pemetrexed/ Carboplatin in Patients With Brain Metastases of Non-squamous NSCLCCompletedNCT04507217Phase 2
• Almonertinib Plus Chemotherapy as First-line Treatment in Patients With EGFR Concomitant Tumor Suppressor Gene MutationStatus unknownNCT04500717Phase 3
• Almonertinib Plus Chemotherapy as First-line Treatment in Patients With EGFR Concomitant Non-EGFR Driver Gene Mutant, Locally Advanced or Metastatic NSCLCStatus unknownNCT04500704Phase 3
• Combination Chemotherapy With or Without Anlotinib in the Maintenance Treatment of Non-Squamous Non-Small Cell Lung Cancer.Status unknownNCT04453423Phase 2
• A Study of the Safety and Tolerance of CAN04 and Pembrolizumab in Combination With and Without Carboplatin and Pemetrexed in Subjects With Solid TumorsCompletedNCT04452214Phase 1
• Pembrolizumab Plus Pemetrexed for Elderly Patients With Non-Sq NSCLC With PD-L1 < 50%: CJLSG1901Status unknownNCT04396457Phase 2
• Efficacy and Safety of Toripalimab (JS001) Combined With Pemetrexed and Anlotinib for Patients With T790M Positive Non-Small Cell Lung Cancer After Osimertinib ResistanceStatus unknownNCT04316351Phase 2
• Pilot Study of Pembrolizumab Combined With Pemetrexed or Abemaciclib for High Grade GliomaWithdrawnNCT04220892Early Phase 1
• Camrelizumab With AC in Patients With Brain Metastases of Driven Gene-negative,NSCLCStatus unknownNCT04211090Phase 2
• Cabozantinib With Pemetrexed in Advanced Non-small Cell Lung Cancer, Urothelial Cancer and Malignant MesotheliomaTerminatedNCT04173338Phase 1

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