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Drug

L-(+)-methylenetetrahydrofolic acid clinical trials

Also written Arfolitixorin and ISO-901.

studies test it
6
open now
1
in phase 3
1
first study started
2012

How each study uses L-(+)-methylenetetrahydrofolic acid is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study

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Approvals

The first approval found in each region, with its record

United States
Not in FDA's approval records
European Union
Not in EMA's list of EU-wide authorisations

From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out

How studies write it

Studies that test it under each name

Name

[6R] 5,10-methylenetetrahydrofolate
2
Modufolin (arfolitixorin)
2

Brand

Modufolin®
1

Development codes

ISO-901
2

Other names

Arfolitixorin
6
6R-MTHF
1

Studies by the year they started

6 studies that test it; most in 2012 (1)

Studies that test L-(+)-methylenetetrahydrofolic acid, by start year
YearStudies
20121
20141
20171
20181
20201
20251

By phase

A phase 1/2 study counts in both.

Phase 1
5
Phase 2
4
Phase 3
1

What it is tested for

Each study’s main condition, where its own words name it, so a study counts once.

Colorectal Neoplasms
3
Colonic Neoplasms
1

Who runs them

Industry 5 · Other 1

Isofol Medical AB (5) · Vastra Gotaland Region (1)

Often tested with

Tested in the same studies.

Fluorouracil (1)

Studies

Open first, then newest update. How each study uses L-(+)-methylenetetrahydrofolic acid is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.

Testing it · 6

Codes

What other systems call L-(+)-methylenetetrahydrofolic acid · ClinicalTrials.gg INT018673

  • UNII (FDA) Z8R4A37V9QARFOLITIXORINConfirmed FDA, Wikidata
  • Wikidata Q26995704L-(+)-methylenetetrahydrofolic acidConfirmed FDA, Wikidata
  • DrugBank DB12676One source Wikidata

“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.