Inclisiran: all 51 studies that test it

Page 1 of 1. Open to participants first (20), then studies with results posted, then the rest; newest registration first within each.

• Comparing Inclisiran Versus Statin for Primary AldosteronismRecruitingNCT07884955Not applicable
• Phase 2 Clinical Study of MWX203 Injection Alone or in Combination With Inclisiran Sodium Injection in Patients With Mixed DyslipidemiaRecruitingNCT07803822Phase 2
• Early Intensive Lipid-Lowering With Inclisiran for Plaque Stabilization in Acute Coronary SyndromeNot yet recruitingNCT07799779Phase 4
• Comparative Assessment of Inclisiran on Top of Standard of Care Versus Standard of Care Alone for LDL-C Evaluation in Acute Coronary Syndrome Patients in Saudi ArabiaNot yet recruitingNCT07684469Phase 4
• Assessment of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a New Formulation of Inclisiran Containing Polysorbate 80 Compared to the Currently Marketed FormulationRecruitingNCT07626281Phase 1
• A Study to Evaluate the Pharmacodynamics of a Combination of QCZ484 and Inclisiran in Participants With Hypertension and Concomitant HypercholesterolemiaRecruitingNCT07610278Phase 2
• Dual PCSK9 Inhibition With Inclisiran and Alirocumab in Secondary PreventionRecruitingNCT07581808Phase 4
• Evaluation of Efficacy and Safety of Early in Hospital Initiation of Inclisiran Treatment in Patients With Acute Coronary SyndromesRecruitingNCT07102628Phase 3
• Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular InterventionRecruitingNCT06909565Phase 4
• LDL-C Optimization Using Inclisiran in Patients in Which Drug-Drug Interactions Limit LDL LoweringRecruitingNCT06865885Phase 4
• Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial HypercholesterolemiaRecruitingNCT06597019Phase 3
• Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial HypercholesterolemiaRecruitingNCT06597006Phase 3
• Effect of Small Interfering RNA Inclisiran on Carotid Plaques As Assessed by Carotid UltrasoundNot yet recruitingNCT06586684Phase 4
• LATAM LOWERS LDL-CRecruitingNCT06501443Phase 4
• The Prevent Coronary Artery Disease TrialRecruitingNCT06494501Phase 3
• Continuity of Care Between Primary Care Cardiology and Specialty Services for Patients With Chronic Ischemic Heart DiseaseNot yet recruitingNCT06421363Phase 4
• Effects of Inclisiran Combined with Statins on the Morphology of Coronary Vulnerable PlaquesRecruitingNCT06338293Phase 4
• Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 StudiesRecruitingNCT05682378Phase 3
• Intensive Lipid-lowering in Patients With STEMI and NSTEMI (Germany on Target)Not yet recruitingNCT05587621Not applicable
• PET Imaging of Inflammation and Lipid Lowering StudyRecruitingNCT04073797Not applicable
• Efficacy and Safety of Inclisiran as Monotherapy in Chinese Adults With Low or Moderate ASCVD Risk and Elevated Low-density Lipoprotein Cholesterol.CompletedNCT05888103Phase 3Results posted
• Efficacy and Safety of Inclisiran as Monotherapy in Patients With Primary Hypercholesterolemia Not Receiving Lipid-lowering Therapy.CompletedNCT05763875Phase 3Results posted
• Study of Efficacy, Safety, Tolerability and Quality of Life of Inclisiran (KJX839) vs Placebo, on Top of Ongoing Individually Optimized Lipid-lowering Therapy, in Participants With HypercholesterolemiaCompletedNCT05192941Phase 4Results posted
• A Randomized Study to Evaluate the Effect of an "Inclisiran First" Implementation Strategy Compared to Usual Care in Patients With Atherosclerotic Cardiovascular Disease and Elevated LDL-C Despite Receiving Maximally Tolerated Statin Therapy (VICTORION-INITIATE)CompletedNCT04929249Phase 3Results posted
• Management of LDL-cholesterol With Inclisiran + Usual Care Compared to Usual Care Alone in Participants With a Recent Acute Coronary SyndromeCompletedNCT04873934Phase 3Results posted
• Study in Primary Care Evaluating Inclisiran Delivery Implementation + Enhanced SupportCompletedNCT04807400Phase 3Results posted
• Study of Efficacy and Safety of Inclisiran in Japanese Participants With High Cardiovascular Risk and Elevated LDL-CCompletedNCT04666298Phase 2Results posted
• Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Homozygous Familial HypercholesterolemiaCompletedNCT04659863Phase 3Results posted
• Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Heterozygous Familial HypercholesterolemiaCompletedNCT04652726Phase 3Results posted
• A Study of Inclisiran in Participants With Homozygous Familial Hypercholesterolemia (HoFH)CompletedNCT03851705Phase 3Results posted
• Trial to Assess the Effect of Long Term Dosing of Inclisiran in Subjects With High CV Risk and Elevated LDL-CCompletedNCT03814187Phase 3Results posted
• Inclisiran for Subjects With ASCVD or ASCVD-Risk Equivalents and Elevated Low-density Lipoprotein CholesterolCompletedNCT03400800Phase 3Results posted
• Inclisiran for Participants With Atherosclerotic Cardiovascular Disease and Elevated Low-density Lipoprotein CholesterolCompletedNCT03399370Phase 3Results posted
• Trial to Evaluate the Effect of Inclisiran Treatment on Low Density Lipoprotein Cholesterol (LDL-C) in Subjects With Heterozygous Familial Hypercholesterolemia (HeFH)CompletedNCT03397121Phase 3Results posted
• A Study of ALN-PCSSC in Participants With Homozygous Familial Hypercholesterolemia (HoFH)CompletedNCT02963311Phase 2Results posted
• Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C)CompletedNCT02597127Phase 2Results posted
• Inclisiran Effectiveness in China: a Pragmatic Randomized TrialActive, not recruitingNCT06941792Phase 4
• Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVDActive, not recruitingNCT06813911Phase 3
• A Study to Investigate LDL-cholesterol Lowering With Inclisiran Compared to Bempedoic Acid in Patients With Atherosclerotic Cardiovascular Disease.CompletedNCT06431763Phase 4
• A Clinical Study to Evaluate the Safety and Effectiveness of Inclisiran Sodium in Indian Patients With Primary Hypercholesterolemia or Mixed DyslipidemiaCompletedNCT06386419Phase 4
• Intravascular Imaging Study of the Effect of Inclisiran on Plaque in Patients With Acute Myocardial InfarctionActive, not recruitingNCT06372925Phase 4
• Aggressive Risk-Prevention Therapies for Coronary Atherosclerotic Plaque (ART-CAP)WithdrawnNCT06280976Phase 4
• VictORION-INCLUSION: Evaluating Inclisiran for Cholesterol Managment in Heart DiseaseActive, not recruitingNCT06249165Phase 4
• A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.Active, not recruitingNCT05739383Phase 3
• Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular EventsActive, not recruitingNCT05360446Phase 3
• Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular DiseaseActive, not recruitingNCT05030428Phase 3
• Study of Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Inclisiran in Chinese Participants With Elevated Serum LDL-CCompletedNCT04774003Phase 1
• Study of Efficacy and Safety of Inclisiran in Asian Participants With Atherosclerotic Cardiovascular Disease (ASCVD) or ASCVD High Risk and Elevated Low Density Lipoprotein Cholesterol (LDL-C)Active, not recruitingNCT04765657Phase 3
• A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular DiseaseActive, not recruitingNCT03705234Phase 3
• A Study of Inclisiran in Participants With Renal Impairment Compared to Participants With Normal Renal Function (ORION-7)CompletedNCT03159416Phase 1
• A Phase 1 Study of an Investigational Drug, ALN-PCSSC, in Subjects With Elevated Low Density Lipoprotein Cholesterol (LDL-C)CompletedNCT02314442Phase 1

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