Bintrafusp alfa: all 46 studies that test it

Page 1 of 1. Open to participants first (2), then studies with results posted, then the rest; newest registration first within each.

• TGF-β And PDL-1 Inhibition in Esophageal Squamous Cell Carcinoma Combined With Chemoradiation TheRapYRecruitingNCT04481256Not applicable
• PDS01ADC Monotherapy and in Combination With M7824 in Advanced Kaposi SarcomaRecruitingNCT04303117Phase 1/2
• Bintrafusp Alfa Program Rollover StudyCompletedNCT05061823Phase 3Results posted
• Phase 2 Study of Bintrafusp Alfa in Recurrent/Metastatic Olfactory Neuroblastoma (BARON).CompletedNCT05012098Phase 2Results posted
• Study of the Efficacy and Safety of the Bintrafusp Alfa in Previously Treated Advanced Malignant Pleural MesotheliomaCompletedNCT05005429Phase 2Results posted
• Bintrafusp Alfa With Chemotherapy for Tyrosine Kinase Inhibitor-Resistant EGFR-Mutant Non-small Cell Lung CancerTerminatedNCT04971187Phase 2Results posted
• Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain MetastasesTerminatedNCT04789668Phase 1/2Results posted
• Phase I/II Trial Investigating the Safety, Tolerability, Pharmacokinetics, Immune and Clinical Activity of SX-682 in Combination With BinTrafusp Alfa (M7824 or TGF-beta "Trap"/PD-L1) With CV301 TRICOM in Advanced Solid Tumors (STAT)CompletedNCT04574583Phase 1/2Results posted
• Bintrafusp Alfa Before Surgery for the Treatment of Untreated Resectable Non-small Cell Lung CancerTerminatedNCT04560686Phase 2Results posted
• A Phase II Study of Bintrafusp Alfa (M7824) in Checkpoint Inhibitor Naive and Refractory Subjects With Urothelial CarcinomaTerminatedNCT04501094Phase 2Results posted
• Bintrafusp Alfa in High Mobility Group AT-Hook 2 (HMGA2) Expressing Triple Negative Breast CancerTerminatedNCT04489940Phase 2Results posted
• First in Human Study of M6223CompletedNCT04457778Phase 1Results posted
• HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated CancersCompletedNCT04432597Phase 1/2Results posted
• Docetaxel With or Without Bintrafusp Alfa for the Treatment of Advanced Non-small Cell Lung CancerTerminatedNCT04396535Phase 2Results posted
• A Study to Evaluate the Efficacy and Safety of Bintrafusp Alfa (M7824) Monotherapy in Metastatic or Locally Advanced Urothelial CancerTerminatedNCT04349280Phase 1Results posted
• Combination Immunotherapy in Subjects With Advanced HPV Associated MalignanciesCompletedNCT04287868Phase 1/2Results posted
• Bintrafusp Alfa Monotherapy in Platinum-Experienced Cervical CancerCompletedNCT04246489Phase 2Results posted
• Bintrafusp Alfa and Stereotactic Body Radiation Therapy for the Treatment of Recurrent or Second Primary Head and Neck Squamous Cell CancerTerminatedNCT04220775Phase 1/2Results posted
• Gemcitabine Plus Cisplatin With or Without Bintrafusp Alfa (M7824) in Participants With 1L BTCTerminatedNCT04066491Phase 2/3Results posted
• M7824 in Combination With Chemotherapy in Stage IV Non-small Cell Lung Cancer (NSCLC)CompletedNCT03840915Phase 1/2Results posted
• M7824 With cCRT in Unresectable Stage III Non-small Cell Lung Cancer (NSCLC)TerminatedNCT03840902Phase 2Results posted
• M7824 Monotherapy in Locally Advanced or Metastatic Second Line (2L) Biliary Tract Cancer (Cholangiocarcinoma and Gallbladder Cancer)CompletedNCT03833661Phase 2Results posted
• M7824 in People With Recurrent Respiratory PapillomatosisCompletedNCT03707587Phase 2Results posted
• M7824 Versus Pembrolizumab as a First-line (1L) Treatment in Participants With Programmed Death-ligand 1 (PD-L1) Expressing Advanced Non-small Cell Lung Cancer (NSCLC)CompletedNCT03631706Phase 3Results posted
• M7824 (MSB0011359C) in Combination With Gemcitabine in Adults With Previously Treated Advanced Adenocarcinoma of the PancreasTerminatedNCT03451773Phase 1/2Results posted
• M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite InstabilityCompletedNCT03436563Phase 1/2Results posted
• M7824 in Subjects With HPV Associated MalignanciesCompletedNCT03427411Phase 2Results posted
• Combination Immunotherapy in Biochemically Recurrent Prostate CancerCompletedNCT03315871Phase 2Results posted
• MSB0011359C (M7824) in Participants With Metastatic or Locally Advanced Solid TumorsCompletedNCT02699515Phase 1Results posted
• MSB0011359C (M7824) in Metastatic or Locally Advanced Solid TumorsCompletedNCT02517398Phase 1Results posted
• N-803 Alone or in Combination With BN-Brachyury Vaccine or Bintrafusp Alfa (M7824) for Participants With Castration Resistant Prostate CancerWithdrawnNCT05445882Phase 2
• Preoperative Bintrafusp Alfa in Operable Urothelial Carcinoma of the BladderStatus unknownNCT04878250Phase 2
• Bintrafusp Alfa and Doxorubicin Hydrochloride in Treating Patients With Advanced SarcomaActive, not recruitingNCT04874311Phase 2
• Study of M7824 and Paclitaxel Combination as a Second-line Treatment in Patients With Recurrent/Metastatic Gastric CancerCompletedNCT04835896Phase 1/2
• Immunotherapy (NHS-IL12 & Bintrafusp Alfa) and Radiation Therapy for the Treatment of Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer, the REINA TrialWithdrawnNCT04756505Phase 1
• Neoadjuvant Bintrafusp Alfa in Patients With Resectable Biliary Tract CancerTerminatedNCT04727541Phase 2
• A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon CancersCompletedNCT04708470Phase 1/2
• Hypofractionated Radiation Therapy and Bintrafusp Alfa for the Treatment of Advanced Intrahepatic CholangiocarcinomaActive, not recruitingNCT04708067Phase 1
• Aerosolized Azacytidine as Epigenetic Priming for Bintrafusp Alfa-Mediated Immune Checkpoint Blockade in Patients With Unresectable Pulmonary Metastases From Sarcomas, Germ Cell Tumors, or Epithelial MalignanciesWithdrawnNCT04648826Phase 1/2
• Evaluation of Bintrafusp Alfa in Operable and Untreated Head and Neck Squamous Cell CarcinomaTerminatedNCT04428047Phase 2
• Bintrafusp Alfa (M7824) in Subjects With Thymoma and Thymic CarcinomaActive, not recruitingNCT04417660Phase 2
• Bintrafusp Alfa in Previously Treated Patients With R/M Non-keratinizing NPCCompletedNCT04396886Phase 2
• Bioimaging Study of 89Zr-M7824 in NSCLCTerminatedNCT04297748Phase 1/2
• M7824 in Treating Patients With Stage II-III HER2 Positive Breast CancerCompletedNCT03620201Phase 1
• M7824 and Eribulin Mesylate in Treating Patients With Metastatic Triple Negative Breast CancerTerminatedNCT03579472Phase 1
• Radiation Therapy and M7824 in Treating Patients With Metastatic Hormone Receptor Positive, HER2 Negative Breast CancerCompletedNCT03524170Phase 1

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