Alpha 1-Antitrypsin: all 50 studies that test it

Page 1 of 1. Open to participants first (4), then studies with results posted, then the rest; newest registration first within each.

• Phase 4, Double-blind Study Evaluating the Response on Computed Tomography (CT) Lung Density Decline Rates of Respreeza / Zemaira Weekly for 3 Years in Adults With alpha1 Antitrypsin Deficiency (AATD)RecruitingNCT07326592Phase 4
• Effect of Alpha-1 Antitrypsin Supplementation on Alcohol-Associated HepatitisRecruitingNCT06582329Phase 2
• Zemaira Eosinophilic Esophagitis Pilot StudyRecruitingNCT05485155Phase 2
• Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin DeficiencyEnrolling by invitationNCT02796937Phase 3
• Treatment of GVHD in Hematopoietic Stem Cell Transplant (HSCT) Recipients Using AAT Plus Corticosteroids (CS) Compared With Corticosteroids AloneCompletedNCT04167514Phase 3Results posted
• A Proof of Concept Pilot Trial of Alpha-1-Antitrypsin for Pre-Emption Of Steroid-Refractory Acute GVHDCompletedNCT03459040Phase 2Results posted
• A Phase 2/3 Study of GLASSIA for the Treatment of Acute GvHDTerminatedNCT02956122Phase 2/3Results posted
• Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic PancreatitisCompletedNCT02947087Phase 1/2Results posted
• Long-term Safety of Alpha1-Proteinase Inhibitor (Human) in Japanese Subjects With Alpha1 Antitrypsin Deficiency (GTI1401-OLE)CompletedNCT02870348Phase 1/2Results posted
• Safety and Pharmacokinetics of Alpha-1 MP (Alpha1-proteinase Inhibitor (Human), Modified Process) in Participants With Alpha1-Antitrypsin DeficiencyCompletedNCT02870309Phase 1/2Results posted
• Stage 1 Study of ARALAST NP and GLASSIA in A1PI DeficiencyTerminatedNCT02722304Phase 3Results posted
• Anti-inflammatory Therapy to Improve Outcomes After TPIATCompletedNCT02713997Phase 4Results posted
• GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage StudyCompletedNCT02525861Phase 3Results posted
• Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal TransplantCompletedNCT02464878Phase 2Results posted
• A Study to Assess Safety and PK of Liquid Alpha₁-Proteinase Inhibitor (Human) in Treating Alpha₁-Antitrypsin DeficiencyCompletedNCT02282527Phase 2/3Results posted
• Study of Human Plasma-Derived Alpha1-Proteinase Inhibitor in Subjects With New-Onset Type 1 Diabetes MellitusTerminatedNCT02093221Phase 2Results posted
• Alpha-1 Anti-Trypsin (AAT) Treatment in Acute Myocardial InfarctionCompletedNCT01936896Phase 1/2Results posted
• Safety and Efficacy of (α1Proteinase Inhibitor, α1PI) in HIV DiseaseTerminatedNCT01731691Phase 2/3Results posted
• A Pilot Study of Alpha-1-Antitrypsin (AAT) in Steroid Refractory Acute Graft vs Host DiseaseCompletedNCT01700036Phase 2Results posted
• Safety and Tolerability Trial of Inhaled Alpha1-Proteinase Inhibitor (Human), Hydrophobic Chromatography Process (Alpha-1 HC) in Subjects With Cystic FibrosisCompletedNCT01684410Phase 2Results posted
• Effect of Double Dose of Alpha 1-antitrypsin Augmentation Therapy on Lung Inflammation.CompletedNCT01669421Phase 2Results posted
• GLASSIA Infusion Rate StudyCompletedNCT01651351Phase 4Results posted
• Alpha 1 Anti-Trypsin (AAT) in Treating Patients With Acute Graft-Versus-Host Disease GVHD)CompletedNCT01523821Phase 1/2Results posted
• Therapy to Elevate CD4 Counts in HIV-1 DiseaseCompletedNCT01370018Phase 2/3Results posted
• Safety and Pharmacokinetics of Alpha-1 Proteinase Inhibitor in Subjects With Alpha1-Antitrypsin DeficiencyCompletedNCT01213043Phase 2Results posted
• A Research Trial of Aralast in New Onset Diabetes (RETAIN)TerminatedNCT01183468Phase 1Results posted
• Deposition of Inhaled Prolastin in Cystic Fibrosis PatientsCompletedNCT00486837Phase 2Results posted
• Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor)CompletedNCT00396006Phase 4Results posted
• The Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) DeficiencyCompletedNCT00301366Phase 3Results posted
• Comparison of Pharmacokinetic, Safety, Tolerability of Alpha-1 MP and Prolastin In Alpha1-antitrypsin Deficient AdultsCompletedNCT00295061Phase 3Results posted
• Alpha-1-Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients (EXACTLE)CompletedNCT00263887Phase 2Results posted
• Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor DeficiencyCompletedNCT00261833Phase 4Results posted
• Bronchiectasis Alpha-1 Augmentation Trial- Modulating Airway Neutrophil FunctionCompletedNCT05582798Phase 4
• A Study of RYMPHYSIA for Alpha1-Proteinase Inhibitor (A1PI) Therapy in Adults With A1PI Deficiency and Chronic Obstructive Pulmonary Disease (COPD)-EmphysemaWithdrawnNCT05466747Phase 4
• Aralast NP With Antiviral Treatment and Standard of Care Versus Antiviral Treatment With Standard of Care in Hospitalized Patients With Pneumonia and COVID-19 InfectionWithdrawnNCT04675086Phase 3
• Study to Evaluate the Safety and Efficacy of Prolastin in Hospitalized Subjects With COVID-19CompletedNCT04495101Phase 2
• ARALAST NP Alpha-1 Lung Density Chronic Obstructive Pulmonary Disease-Emphysema (COPD-E) StudyWithdrawnNCT04440488Phase 4
• Phase III, Efficacy and Safety of "Kamada-AAT for Inhalation"TerminatedNCT04204252Phase 3
• The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft-versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell TransplantTerminatedNCT03805789Phase 2/3
• Aralast NP in Islet TransplantCompletedNCT02520076Phase 1/2
• Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac SurgeryStatus unknownNCT02191839Phase 1/2
• Pilot Study of alpha1-antitrypsin to Treat Neuromyelitis Optica RelapsesWithdrawnNCT02087813Phase 1
• Alpha1 Antitrypsin Aerosol Therapy in Cystic FibrosisTerminatedNCT02010411Phase 2
• Phase II Study to Evaluate the Efficacy and Safety of Glassia® in Type-1 DiabetesCompletedNCT02005848Phase 2
• Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD)CompletedNCT01983241Phase 3
• Long Term Treatment Effect of the Safety, Tolerability and Efficacy of AAT in Type 1 DiabetesCompletedNCT01661192Phase 2
• Safety and Efficacy of Inhaled Alpha-1 Antitrypsin in Preventing Bronchiolitis Obliterable Syndrome in Lung Transplant RecipientsStatus unknownNCT01394835Phase 2
• The Effects of Alpha-1 Antitrypsin (AAT) on the Progression of Type 1 DiabetesCompletedNCT01319331Phase 1
• Study of the Safety and Efficacy of Intravenous Alpha-1 Antitrypsin in Type 1 Diabetes MellitusCompletedNCT01304537Phase 1/2
• A Research Trial of Aralast NP in New Onset Diabetes (RETAIN) - Part IIWithdrawnNCT01183455Phase 2

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