Optic Atrophy clinical trials
The registry lists 16 studies for Optic Atrophy across more than 10 countries. 3 are recruiting or about to start. 4 of them are mainly about Optic Atrophy (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-27. Counting its narrower condition Optic Atrophy, Hereditary, Leber too: 58 studies, 11 open.
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Who runs them
Washington University School of Medicine (3) · State University of New York at Buffalo (2) · MD Stem Cells (2) · Quark Pharmaceuticals (1) · Visionary Intelligence Ltd. (1) · Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · The Foundation for Orthopaedics and Regenerative Medicine (1)
What is being tested here
Drugs under test in Optic Atrophy studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| CHF-6467 | 0 | 0 | 1 |
| Dantrolene | 0 | 0 | 1 |
| QPI-1007 | 0 | 0 | 1 |
| Deferiprone | 0 | 1 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Apr 2027Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study · Washington University School of Medicine
- Jun 2027Safety and Efficacy of the PAINLESS Nerve Growth Factor CHF6467 in Optic Pathway Glioma (OPG) · Benedetto Falsini
- Jul 2027Stem Cell Ophthalmology Treatment Study II · MD Stem Cells
Who these studies take
Of the 3 Optic Atrophy studies recruiting now, 3 (100%) set no upper age limit and 0 (0%) stop at 75 or younger. 2 (67%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (67%) | 2 (67%) |
| 18 | 3 (100%) | 3 (100%) |
| 30 | 3 (100%) | 3 (100%) |
| 40 | 3 (100%) | 3 (100%) |
| 50 | 3 (100%) | 3 (100%) |
| 65 | 3 (100%) | 3 (100%) |
| 75 | 3 (100%) | 3 (100%) |
| 85 | 3 (100%) | 3 (100%) |
Across all 16 studies, recruiting or not: 44% stop at 75 or younger and 31% at 65; 56% take children; 0% are for women only and 0% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 16 of 16. search them.
- Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for NAIONRecruitingNCT05147701Phase 12 countries
- Stem Cell Ophthalmology Treatment Study IIRecruitingNCT03011541Not applicable3 countries
- Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical StudyRecruitingNCT028415531 country
- Safety and Efficacy of the PAINLESS Nerve Growth Factor CHF6467 in Optic Pathway Glioma (OPG)Active, not recruitingNCT05733572Phase 21 country
- I-Tracking Neurodegeneration in Early Wolfram SyndromeCompletedNCT039512981 country
- Building Research With Artificial Intelligence in Neuro-OphthalmologyCompletedNCT063905791 country
- A Clinical Trial of Dantrolene Sodium in Pediatric and Adult Patients With Wolfram SyndromeCompletedNCT02829268Phase 1/21 country
- Natural History Study of FDXR Mutation-related MitochondriopathyCompletedNCT045809791 country
- Natural History Study of SLC25A46 Mutation-related MitochondriopathyCompletedNCT045945901 country
- Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus PhotographCompletedNCT047231601 country
- Systemic Erythropoietin Injection in Patients Having Optic AtrophyCompletedNCT04680143Phase 1/21 country
- Stem Cell Ophthalmology Treatment StudyStatus unknownNCT01920867Not applicable1 country
- Effectiveness and Safety of Adipose-Derived Regenerative Cells for Treatment of Glaucomatous NeurodegenerationStatus unknownNCT02144103Phase 1/21 country
- Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based TherapyStatus unknownNCT02882477Phase 2/31 country
- Study the Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Optic Nerve DiseaseStatus unknownNCT01834079Phase 1/21 country
- Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION PatientsCompletedNCT01064505Phase 12 countries