Limbal Stem Cell Deficiency clinical trials
The registry lists 38 studies for Limbal Stem Cell Deficiency across more than 10 countries. 15 are recruiting or about to start. 34 of them are mainly about Limbal Stem Cell Deficiency (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-28.
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Who runs them
National Taiwan University Hospital (4) · Claris Biotherapeutics, Inc. (2) · Royan Institute (2) · Chunxiao Wang (2) · Holostem s.r.l. (2) · Hospices Civils de Lyon (1) · Siriraj Hospital (1) · Veerle Van Gerwen (1)
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
- Dec 2026Efficacy of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease · University of Illinois Chicago
- Feb 2027Stem Cell Therapy for Limbal Stem Cell Deficiency · University of California, Los Angeles
Who these studies take
Of the 9 Limbal Stem Cell Deficiency studies recruiting now, 5 (56%) set no upper age limit and 1 (11%) stop at 75 or younger. 4 (44%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (33%) | 3 (33%) |
| 18 | 9 (100%) | 9 (100%) |
| 30 | 9 (100%) | 9 (100%) |
| 40 | 9 (100%) | 9 (100%) |
| 50 | 9 (100%) | 9 (100%) |
| 65 | 9 (100%) | 9 (100%) |
| 75 | 8 (89%) | 8 (89%) |
| 85 | 8 (89%) | 8 (89%) |
Across all 38 studies, recruiting or not: 16% stop at 75 or younger and 5% at 65; 42% take children; 0% are for women only and 0% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 38 of 38. search them.
- Efficacy of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface DiseaseRecruitingNCT06919081Phase 21 country
- Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Limbal Stem Cell DeficiencyRecruitingNCT06452316Phase 11 country
- Multi-Center, Prospective, Non-Interventional Study in Subjects With Limbal Stem Cell DeficiencyRecruitingNCT076365901 country
- Clinical Predictors of Visual Outcome in Patients Affected With Ocular Surface DiseasesNot yet recruitingNCT076948171 country
- BRM421 Ophthalmic Solution in Patients With Limbal Stem Cell DeficiencyAvailableNCT074223891 country
- Cultured Autologous Oral Mucosa Epithelial Sheet for the Treatment of Bilateral Limbal Stem Cell DeficiencyRecruitingNCT03949881Phase 1/21 country
- Association Between Limbal Function and Tear Proteomics in Chronic Ocular Diseases: Focusing on GlaucomaRecruitingNCT071195801 country
- Autologous Cultured Corneal Epithelium (CECA) for the Treatment of Limbal Stem Cell DeficiencyRecruitingNCT01756365Not applicable1 country
- Cultivated Limbal Epithelial Transplantation (CLET) for Limbal Stem Cell Deficiency (LSCD)Not yet recruitingNCT038845691 country
- A Clinical Study on Co-transplantation of Autologous Limbal Stem Cells and Corneal Stromal Stem Cells to Repair Corneal InjuryNot yet recruitingNCT06700655Phase 1/2
- Validation of Human Drugs Target of Repurposed Drugs and Novel TherapiesNot yet recruitingNCT06412718
- Labial Mucosal Epithelium Grafting for Corneal Limbus SubstitutionRecruitingNCT04995926Not applicable1 country
- The Effects of Allogeneic SLETRecruitingNCT040211341 country
- The Effects of Autologous SLETRecruitingNCT040218751 country
- Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet TransplantationAvailableNCT021497321 country
- Cultivated Stem Cell Transplantation for the Treatment of Limbal Stem Cell DeficiencyCompletedNCT00845117Not applicable1 country
- Stem Cell Therapy for Limbal Stem Cell DeficiencyActive, not recruitingNCT03957954Phase 11 country
- Treatment of LSCD With DMCompletedNCT05909735Phase 11 country
- Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) GraftCompletedNCT02592330Phase 1/21 country
- Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter TrialCompletedNCT02318485Phase 21 country
- Implementation of a Protocol for the Transdifferentiation of Buccal Mucosal Epithelium Into Corneal EpitheliumStatus unknownNCT06265298Not applicable1 country
- CDL Validation StudyCompletedNCT054614691 country
- Follow-up Study After ACLSCT for Restoration of Corneal Epithelium in Patients With LSCD Due to Ocular BurnsCompletedNCT032888441 country
- Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of LSCDStatus unknownNCT03549299Phase 1/22 countries
- Efficacy and Safety of Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for Restoration of Corneal Epithelium in Patients With Limbal Stem Cell DeficiencyCompletedNCT02577861Phase 41 country
- Cultivated Autologous Oral Mucosal Epithelial TransplantationStatus unknownNCT03943797Phase 11 country
- Corneal Epithelial Allograft From Living-related Donor for LSCDCompletedNCT03217435Not applicable1 country
- Transplantation of Autologous Oral Mucosal Epithelial Sheets for Limbal Stem-cell DeficiencyCompletedNCT02415218Phase 1/21 country
- Corneal Epithelial Autograft for LSCDStatus unknownNCT03217487Not applicable1 country
- Multiple Noninvasive Examination Modality to Evaluate the Severity of Ocular Surface DisordersCompletedNCT035943701 country
- Biodegradable Synthetic Scaffold as a Substitute for hAM in Limbal Epithelial Cells Transplant in LSCD PatientsCompletedNCT02568527Not applicable1 country
- ABCB5 as a Prognostic Marker in Survival of Cultivated Limbal Stem Cell TransplantationTerminatedNCT02579993Not applicable1 country
- Autologous Oral Mucosa Transplantation for Limbal Stem Cell DeficiencyCompletedNCT03226015
- Correlation of Gene Abnormalities and Clinical Manifestations of AniridiaCompletedNCT002655901 country
- Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency DiseaseStatus unknownNCT03015779Phase 1/2
- The Improvement of Limbal Stem Cell Deficiency (LSCD) in Unilateral Stem Cell Damage by Amniotic Membrane Extract Eye Drop (AMEED)CompletedNCT02649621Phase 1
- Multicenter Study of CAOMECS Transplantation to Patients With Total Limbal Stem Cell DeficiencyWithdrawnNCT01489501Phase 31 country
- Autologous Transplantation of Cultivated Limbal Stem Cells on Amniotic Membrane in Limbal Stem Cell Deficiency (LSD) PatientsCompletedNCT00736307Phase 1/21 country