Leukemia, Myelomonocytic, Chronic clinical trials
The registry lists 540 studies for Leukemia, Myelomonocytic, Chronic across more than 10 countries. 69 are recruiting or about to start. 85 of them are mainly about Leukemia, Myelomonocytic, Chronic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
ClinicalTrials.gov finds 624 studies for Leukemia, Myelomonocytic, Chronic. How that becomes 540 here
This page counts the studies the registry files under Leukemia, Myelomonocytic, Chronic, and those it files under no condition that list Leukemia, Myelomonocytic, Chronicthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 624Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −9List Leukemia, Myelomonocytic, Chronic as a condition, but the registry did not file them under itMost often written as “Chronic Myelomonocytic Leukemia-2” (4), “Chronic Myelomonocytic Leukemia in Remission” (1), and “Acute Myeloid Leukaemia; Myelodysplastic Syndromes;Chronic Myelomonocytic Leukemia” (1). The registry filed them under other conditions only, most often Myelodysplastic Syndromes (6) and Leukemia, Myeloid, Acute (5).
- −75Match it another way13 name it in the title, 3 in a keyword, and 59 by a synonym or other text the search reads.
- 540The count on this page
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· Enrollment: 300 → 450 participants
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Who runs them
M.D. Anderson Cancer Center (53) · Fred Hutchinson Cancer Center (45) · National Cancer Institute (NCI) (41) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (21) · Memorial Sloan Kettering Cancer Center (15) · City of Hope Medical Center (13) · Roswell Park Cancer Institute (12) · Case Comprehensive Cancer Center (11)
What is being tested here
Drugs under test in Leukemia, Myelomonocytic, Chronic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Cyclophosphamide | 6 | 4 | 54 |
| Fludarabine | 6 | 2 | 54 |
| Venetoclax | 4 | 1 | 13 |
| Fludarabine phosphate | 3 | 2 | 45 |
| Azacitidine | 3 | 3 | 38 |
| Tacrolimus | 3 | 0 | 22 |
| Decitabine | 3 | 3 | 22 |
| Cytarabine | 3 | 0 | 18 |
| Pacritinib | 3 | 0 | 6 |
| Busulfan | 2 | 4 | 33 |
Drug classes tested here Antimetabolites 16 open · Tyrosine kinase inhibitors (TKIs) 12 open · Alkylating agents 10 open · JAK inhibitors 6 open · Calcineurin inhibitors 5 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2027A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study) · Phase 3 · Taiho Oncology, Inc.
- Nov 2026Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia · Aptose Biosciences Inc.
- Dec 2026HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis · Center for International Blood and Marrow Transplant Research
- Dec 2026Vorinostat and Azacitidine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia · National Cancer Institute (NCI)
- Dec 2026A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm · AbbVie
- Dec 2026A Phase II, Open-Label, Study of Subcutaneous Canakinumab, an Anti-IL-1β Human Monoclonal Antibody, for Patients With Low or Int-1 Risk IPSS/IPSS-R Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia · M.D. Anderson Cancer Center
- Dec 2026A Phase 1 Study of STX-0712 in Patients With Advanced Hematological Malignancies (CMML and AML) · Solu Therapeutics, Inc
- Dec 2026Unrelated Umbilical Cord Blood Stem Cell Combined With Azacitidine Based Treatment for Advanced MDS,CMML-2 and sAML · The First Affiliated Hospital with Nanjing Medical University
- Jan 2027A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias · Crossbow Therapeutics, Inc.
- Jan 2027Phase I/II Study of Tagraxofusp in Combination With Decitabine for Patients With Myelomonocytic/Myeloproliferative Neoplasm and High Risk Myelodysplastic Syndromes · M.D. Anderson Cancer Center
Who these studies take
Of the 63 Leukemia, Myelomonocytic, Chronic studies recruiting now, 47 (75%) set no upper age limit and 7 (11%) stop at 75 or younger. 8 (13%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (5%) | 3 (5%) |
| 18 | 62 (98%) | 62 (98%) |
| 30 | 62 (98%) | 62 (98%) |
| 40 | 62 (98%) | 62 (98%) |
| 50 | 62 (98%) | 62 (98%) |
| 65 | 62 (98%) | 62 (98%) |
| 75 | 59 (94%) | 59 (94%) |
| 85 | 50 (79%) | 50 (79%) |
Across all 540 studies, recruiting or not: 23% stop at 75 or younger and 14% at 65; 28% take children; 0% are for women only and <1% for men only; 2% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Leukemia, Myelomonocytic, Chronic studies take
Of 69 phase 2 interventional studies under Leukemia, Myelomonocytic, Chronic, half reached primary completion within 68 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 51 mo31–74 · 66 studies | — | 51 mo35–90 · 43 studies |
| Phase 1/2 | 106 mo64–112 · 36 studies | — | — |
| Phase 2 | 68 mo46–110 · 69 studies | — | 70 mo46–111 · 62 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Stopped1
- Hu8F4 in Treating Patients With Advanced Hematologic MalignanciesTerminatedNov 4, 2026NCT02530034
Studies
Recruiting first, then most recently updated. Showing 50 of 540. Browse all 540 → or search them.
- Axatilimab With or Without Azacitidine for the Treatment of Patients With Advanced Phase Myeloproliferative Neoplasms, Myeloproliferative Neoplasm/Myelodysplastic Syndrome Overlap or High Risk Chronic Myelomonocytic LeukemiaRecruitingNCT06523556Phase 1/21 country
- Ropeginterferon Alfa-2b for the Treatment of Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes and Chronic Myelomonocytic LeukemiaNot yet recruitingNCT07468916Phase 21 country
- Personalized NK Cell Therapy in CBTRecruitingNCT02727803Phase 21 country
- Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic MalignanciesRecruitingNCT06904066Phase 11 country
- Therapeutic RSK1 Targeting in Myeloid MalignanciesRecruitingNCT07379125Phase 11 country
- Olutasidenib for the Treatment of Patients With IDH1 Mutated AML, MDS or CMML After Donor Hematopoietic Cell TransplantRecruitingNCT06543381Phase 11 country
- Effects of IL-1 Beta Inhibition on Vascular Inflammation in TET2 Clonal HematopoiesisRecruitingNCT06691217Phase 21 country
- Phase I/II Clinical Trial of Axatilimab, a CSF1R Monoclonal Antibody, in Combination With Ruxolitinib as Therapy for Patients With Myelofibrosis (MF) and Chronic Myelomonocytic Leukemia (CMML)RecruitingNCT07128381Phase 1/21 country
- Screening Study for KIT D816V Mutated Mast Cell Disease in Select PopulationsRecruitingNCT071436692 countries
- CPX-351 in Treating Patients With Relapsed or Refractory High Risk Myelodysplastic Syndrome or Chronic Myelomonocytic LeukemiaRecruitingNCT03896269Phase 11 country
- A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)RecruitingNCT04256317Phase 2/310 countries
- Azacitidine, Venetoclax, and Gilteritinib in Treating Patients With Recurrent/Refractory FLT3-Mutated Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, or High-Risk Myelodysplastic Syndrome/Myeloproliferative NeoplasmRecruitingNCT04140487Phase 1/21 country
- Phenotypic and Functional Characterization of Bone Marrow Macrophages in Chronic Myelomonocytic LeukemiaNot yet recruitingNCT07852494Not applicable1 country
- Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic LeukemiaRecruitingNCT03418038Phase 21 country
- CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic LeukemiaRecruitingNCT04375631Phase 11 country
- Venetoclax in Addition to Sequential Conditioning With Fludarabine / Amsacrine / Ara-C (FLAMSA) + Treosulfan for Allogeneic Blood Stem Cell Transplantation in Patients With MDS, CMML or sAMLRecruitingNCT05807932Phase 1/21 country
- Thiotepa-Containing Conditioning Regimen for Allogeneic HSCT in Chronic Myelomonocytic LeukemiaRecruitingNCT07588594Not applicable1 country
- (Apex) Bezuclastinib in Patients With Advanced Systemic MastocytosisRecruitingNCT04996875Phase 214 countries
- Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene MutationRecruitingNCT03683433Phase 21 country
- A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of Undetermined Significance and Lower-risk Myelodysplastic/Syndromes/Chronic Myelomonocytic Leukemia.RecruitingNCT06566742Phase 21 country
- A Study to Assess Safety and Preliminary Efficacy of LP-108 Combined With Azacitidine In Subjects With AML, MDS, CMMLRecruitingNCT05641259Phase 11 country
- Biological, Prospective Study Evaluating the Dosage of Plasma Cytokines Including the FLT3 Ligand and IL6 of Patients Treated With Non-intensive ChemotherapyRecruitingNCT064391991 country
- Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic SyndromeRecruitingNCT03383575Phase 21 country
- Dose-Expansion Study of Low Dose Post-Transplant Cyclophosphamide/Tacrolimus/Ruxolitinib for Graft-versus-Host Disease (GVHD) Prophylaxis in Myeloablative Allogeneic Peripheral Blood Stem Cell TransplantationRecruitingNCT07249346Phase 21 country
- Pacritinib vs. Hydroxyurea in Advanced Proliferative Chronic Myelomonocytic LeukemiaRecruitingNCT07033598Phase 22 countries
- TACrolimus Targeted Immunosuppression Cessation in ALlogeneic HCTRecruitingNCT07302776Phase 11 country
- Pacritinib in CMMLRecruitingNCT06159491Phase 1/21 country
- Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With High-Risk AML and MDSRecruitingNCT04708054Phase 2/31 country
- Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological MalignancesRecruitingNCT05092451Phase 1/21 country
- A Study for Participants Who Participated in Prior Clinical Studies of ASTX727 (Standard Dose)Enrolling by invitationNCT04093570Phase 213 countries
- A Study to Evaluate S241656 Alone or in Combination in Participants With Selected Myeloid MalignanciesNot yet recruitingNCT07719348Phase 1/2
- Combination Chemotherapy (FLAG-Ida) Followed Immediately by Reduced-Intensity Total Body Radiation Therapy and Donor Hematopoietic Cell Transplant for the Treatment of Adults Age 60 and Older With Newly Diagnosed Adverse-Risk Acute Myeloid Leukemia or Other High-Grade Myeloid CancerRecruitingNCT07046078Phase 21 country
- Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity ConditioningRecruitingNCT06815003Phase 21 country
- Registry of Older Patients With CancerRecruitingNCT011378251 country
- Onvansertib for the Treatment of Recurrent or Refractory Chronic Myelomonocytic Leukemia and Myelodysplastic Syndrome/MPN Overlap NeoplasmsRecruitingNCT05549661Phase 11 country
- 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute LeukemiaRecruitingNCT03128034Phase 1/21 country
- 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic SyndromeRecruitingNCT03670966Phase 1/21 country
- Study to Evaluate the Safety and Tolerability of EP0042RecruitingNCT04581512Phase 1/23 countries
- Relevance of Peripheral Cells in the Pathophysiology of Chronic Myelomonocytic Leukemia (CMML)RecruitingNCT032808881 country
- Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) TransplantRecruitingNCT03964506Early Phase 11 country
- Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological MalignanciesRecruitingNCT04195633Phase 21 country
- A Phase II, Open-Label, Study of Subcutaneous Canakinumab, an Anti-IL-1β Human Monoclonal Antibody, for Patients With Low or Int-1 Risk IPSS/IPSS-R Myelodysplastic Syndromes and Chronic Myelomonocytic LeukemiaRecruitingNCT04239157Phase 21 country
- Cohort of Patients With Chronic Myelomonocytic LeukemiaRecruitingNCT075128821 country
- HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell TransplantRecruitingNCT03326921Phase 11 country
- Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of RelapseRecruitingNCT06928662Phase 1/21 country
- Methods of T Cell Depletion Trial (MoTD)RecruitingNCT04888741Phase 21 country
- Momelotinib in Combination With Hypomethylating Agent for Chronic Phase Myelodysplastic Syndromes/Myeloproliferative Overlap Neoplasms and Chronic Neutrophilic LeukemiaRecruitingNCT07071155Early Phase 11 country
- Combined Evaluation of Epigenetic and Sensitising Therapy in AML and MDSRecruitingNCT05636514Phase 11 country
- A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell TransplantationRecruitingNCT06859424Phase 21 country
- A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid LeukemiasRecruitingNCT06994676Phase 11 country