Glomerulosclerosis, Focal Segmental clinical trials
The registry lists 105 studies for Glomerulosclerosis, Focal Segmental across more than 10 countries. 33 are recruiting or about to start. 60 of them are mainly about Glomerulosclerosis, Focal Segmental (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (11) · Travere Therapeutics, Inc. (6) · Northwell Health (6) · University of Michigan (5) · Goldfinch Bio, Inc. (3) · Vertex Pharmaceuticals Incorporated (3) · Amgen (2) · Istanbul University (2)
What is being tested here
Drugs under test in Glomerulosclerosis, Focal Segmental studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Sparsentan | 1 | 1 | 5 |
| Propagermanium | 1 | 1 | 2 |
| Sibeprenlimab | 1 | 0 | 1 |
| Praliciguat | 1 | 0 | 1 |
| BI-764198 | 1 | 1 | 1 |
| N-acetylmannosamine | 1 | 0 | 1 |
| Frexalimab | 1 | 0 | 1 |
| Brivekimig | 1 | 0 | 1 |
| Rilzabrutinib | 1 | 0 | 1 |
| BAT4406F | 1 | 1 | 1 |
Drug classes tested here Angiotensin receptor blockers (ARBs) 1 open · Endothelin receptor antagonists 1 open · Corticosteroids 5 · Calcineurin inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Proteinuria in Pre and Post Transplant · University of Miami
- Dec 2026A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease · Sanofi
- Jan 2027INS, B Cells and Microbiota · Nantes University Hospital
- Mar 2027Sparsentan in Posttransplant Immunoglobulin A Nephropathy or Focal Segmental Glomerulosclerosis · Travere Therapeutics, Inc.
- Mar 2027A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS) · Northwell Health
- Mar 2027taVNS for FRNS in Children · Northwell Health
- Mar 2027Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases · Travere Therapeutics, Inc.
- Jun 2027A Study of Praliciguat in Participants With Focal Segmental Glomerulosclerosis (FSGS) · Akebia Therapeutics
- Sep 2027Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children · Kaneka Medical America LLC
- Sep 2027Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 System · Kaneka Medical America LLC
Who these studies take
Of the 30 Glomerulosclerosis, Focal Segmental studies recruiting now, 11 (37%) set no upper age limit and 12 (40%) stop at 75 or younger. 22 (73%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (7%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 18 (60%) | 18 (60%) |
| 18 | 27 (90%) | 27 (90%) |
| 30 | 24 (80%) | 24 (80%) |
| 40 | 24 (80%) | 24 (80%) |
| 50 | 23 (77%) | 23 (77%) |
| 65 | 23 (77%) | 23 (77%) |
| 75 | 23 (77%) | 23 (77%) |
| 85 | 14 (47%) | 14 (47%) |
Across all 105 studies, recruiting or not: 46% stop at 75 or younger and 30% at 65; 52% take children; 0% are for women only and 0% for men only; 10% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Glomerulosclerosis, Focal Segmental studies take
Of 17 phase 2 interventional studies under Glomerulosclerosis, Focal Segmental, half reached primary completion within 35 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 35 mo21–42 · 17 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
- MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)Oct 23, 2026NCT07892651
Studies
Recruiting first, then most recently updated. Showing 50 of 105. Browse all 105 → or search them.
- NEPTUNE Match StudyRecruitingNCT04571658Not applicable1 country
- Nephrotic Syndrome Study NetworkRecruitingNCT012090002 countries
- A Study of Praliciguat in Participants With Focal Segmental Glomerulosclerosis (FSGS)RecruitingNCT07268638Phase 21 country
- A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)RecruitingNCT07220083Phase 340 countries
- An Open-Label Phase 2 Study of N-Acetyl-D-Mannosamine (ManNAc) in Subjects With Podocyte DiseasesRecruitingNCT06664814Phase 21 country
- MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)Not yet recruitingNCT078926511 country
- A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change DiseaseRecruitingNCT06500702Phase 222 countries
- A Study to Evaluate the Effectiveness and Safety of Sibeprenlimab in Participants With Primary Membranous Nephropathy, Immune-mediated Focal Segmental Glomerulosclerosis, and Minimal Change DiseaseNot yet recruitingNCT07861113Phase 2
- Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in ChildrenRecruitingNCT02235857Not applicable1 country
- Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 SystemRecruitingNCT04065438Not applicable1 country
- Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of EVER001 in Participants With Selected Proteinuric Glomerular DiseasesRecruitingNCT07614477Phase 21 country
- Epithelial Dysmetabolism and Renal Fibrosis in ANCA VasculitisRecruitingNCT070102501 country
- Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular DiseasesRecruitingNCT05003986Phase 28 countries
- Recurrence Post-transplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change DiseaseRecruitingNCT056506191 country
- A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS)RecruitingNCT05583942Not applicable1 country
- taVNS for FRNS in ChildrenRecruitingNCT05588063Not applicable1 country
- SLIT ABS: Study on Patients With Autoimmune PodocytopathyRecruitingNCT07516964Not applicable5 countries
- A Clinical Study of BAT4406F Injection in Patients With Minimal Change Disease/Focal Segmental GlomerulosclerosisRecruitingNCT07499700Phase 2/31 country
- INS, B Cells and MicrobiotaRecruitingNCT049247121 country
- AMPK-activation by Metformin in FSGS: AMP-FSGSRecruitingNCT06090227Phase 1/21 country
- A Study of the Efficacy and Safety of DMX-200 in Patients With FSGS Who Are Receiving an ARBRecruitingNCT05183646Phase 321 countries
- Interview Study of Adult and Child Patients and Parents of Children With Swelling Due to Nephrotic Syndrome.RecruitingNCT055055001 country
- Proteinuria in Pre and Post TransplantRecruitingNCT010943271 country
- The FOrMe Registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry)RecruitingNCT039499721 country
- Autoantibodies Against-nephrin in Idiopathic Nephrotic SyndromeRecruitingNCT063346921 country
- Raman Spectroscopy Diagnosis of Kidney DiseasesRecruitingNCT067608451 country
- A First in Human Study to Evaluate Safety, Tolerability, Pharmacology of HS-10390 in Healthy SubjectsRecruitingNCT05942625Phase 11 country
- Predictive Determinants of Nephrotic Syndrome Remission in Patients With At-risk Polymorphism of APOL1Not yet recruitingNCT064430341 country
- ARREST-NEPHROSIS - Austrian Resistant Nephrotic Syndrome Treatment Response Registry and BiobankRecruitingNCT061625461 country
- National Registry of Rare Kidney DiseasesRecruitingNCT060658521 country
- China Kidney Patient Trials NetworkRecruitingNCT050368501 country
- INSIGHT (Insight Into Nephrotic Syndrome)RecruitingNCT016052661 country
- KOrea Renal Biobank NEtwoRk System TOward NExt-generation AnalysisRecruitingNCT039298871 country
- Genetic Markers for Focal Segmental GlomerulosclerosisCompletedNCT000013931 country
- Focal Segmental Glomerulosclerosis Clinical Trial (FSGS-CT)CompletedNCT00135811Phase 31 country
- Immunophenotyping Profiling in Patients With Primary Nephrotic SyndromeCompletedNCT077029811 country
- Obinutuzumab in Primary FSGSCompletedNCT04983888Phase 21 country
- Sparsentan in Posttransplant Immunoglobulin A Nephropathy or Focal Segmental GlomerulosclerosisActive, not recruitingNCT07219121Phase 41 country
- Genetic Causes of FSGS, Nephrotic Syndrome, or Kidney FailureActive, not recruitingNCT021945821 country
- Atrasentan in Patients With Proteinuric Glomerular DiseasesActive, not recruitingNCT04573920Phase 26 countries
- REduced-dose Steroid PrOtocol for Childhood Nephrotic SyndromE (RESPONSE)Active, not recruitingNCT06635720Phase 31 country
- Janus Kinase-STAT Inhibition to Reduce APOL1 Associated Kidney DiseaseCompletedNCT05237388Phase 21 country
- Study of Sparsentan in Patients With Primary Focal Segmental Glomerulosclerosis (FSGS)CompletedNCT03493685Phase 322 countries
- Global Kidney Patient Trials NetworkCompletedNCT043898271 country
- Study to Evaluate R3R01 in Patients With Alport Syndrome and Patients With Focal Segmental GlomerulosclerosisCompletedNCT05267262Phase 26 countries
- Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental GlomerulosclerosisCompletedNCT04340362Phase 24 countries
- PRI-VENT FSGS: Preemptive Rituximab to Prevent Recurrent Focal Segmental Glomerulosclerosis Post-TransplantCompletedNCT03763643Early Phase 11 country
- A Phase 2 Trial of the Safety and Efficacy of Bardoxolone Methyl in Patients With Rare Chronic Kidney Diseases - PHOENIXCompletedNCT03366337Phase 21 country
- Randomized, Double-Blind, Safety and Efficacy Study of RE-021 (Sparsentan) in Focal Segmental GlomerulosclerosisCompletedNCT01613118Phase 23 countries
- Rituximab Treatment of Focal Segmental GlomerulosclerosisWithdrawnNCT00550342Phase 21 country