Giant Cell Tumor of Bone clinical trials
The registry lists 23 studies for Giant Cell Tumor of Bone across more than 10 countries. 7 are recruiting or about to start. 19 of them are mainly about Giant Cell Tumor of Bone (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
Amgen (4) · Shanghai JMT-Bio Inc. (3) · Istituto Ortopedico Rizzoli (2) · M.D. Anderson Cancer Center (1) · Second Affiliated Hospital, School of Medicine, Zhejiang University (1) · Leiden University Medical Center (1) · Tang Xiaodong (1) · St. Louis University (1)
Who develops what
Save this setEvery programme with a company-led study here in the last two years, whatever its size: 0 programmes from 0 companies, 0 with this as their studies’ main aim; 0 with a live phase 3 study; 0 primary completions in the next 12 months.
Stage, biomarker and line of therapy are not read yet: these programmes are in development here, not all in the same competitive position.
Comparator & background therapies
What other companies’ phase 2+ studies give as the comparator or the background here (its leading trial sponsor and partners left out): a sign of what new drugs are measured against, not by itself the standard of care, its prescriptions or its market.
| Drug | Leading trial sponsor · rights | Companies, last 5 years |
|---|---|---|
DenosumabRecent, limitedEvidence
| Amgen70% of its industry studiesUS: Amgen (FDA 2010) + 9 othersEU: Amgen (EMA 2010) + 29 others | 11 study |
Programmes
“Meets, by arms” reads each study’s arms: vs its arm against the therapy’s; + X vs a combination against it; added to it plus the therapy against the therapy; studied with given together only. The next primary completion is the next phase-3 study’s when there is one.
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Primary completion in the next 12 months (0)
Live phase 2 and 3 studies of these programmes. Primary completion is when the main measure’s data collection ends, as the registry states it (most are estimates); results come later, if they are announced.
None in the next 12 months.
Read from ClinicalTrials.gov, industry-led studies. Main aim: this is the study’s judged main condition; named, not the main aim: the sponsor names it, the study is about something else; registry mapping only: only the registry’s mapping put it here. Leading trial sponsor is the company leading the most industry studies of a drug, a measure of trial activity, not of rights. US and EU rights, and Approved: from the regulators’ records (FDA’s Drugs@FDA via openFDA; EMA’s medicines data) — the holder of a marketed or authorised original, generics and other companies’ versions; not rights elsewhere, nor approval for this condition. Phase 4 trial recorded, where neither lists it: a phase 4 study exists somewhere. Not read yet: labels by indication, exclusivity, licences, line of therapy, academic comparators, sales.
What is being tested here
Drugs under test in Giant Cell Tumor of Bone studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3, phase 3 first
- Jan 2027Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone · Phase 3 · St. Louis University
- Dec 2026Accuracy of Indocyanine Green (ICG) Fluorescence Imaging in Giant Cell Tumor of Bone Surgery · Shanghai Jiao Tong University Affiliated Sixth People's Hospital
- Apr 2027LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas · M.D. Anderson Cancer Center
Who these studies take
Of the 6 Giant Cell Tumor of Bone studies recruiting now, 4 (67%) set no upper age limit and 2 (33%) stop at 75 or younger. 1 (17%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (17%) | 1 (17%) |
| 18 | 6 (100%) | 6 (100%) |
| 30 | 6 (100%) | 6 (100%) |
| 40 | 6 (100%) | 6 (100%) |
| 50 | 6 (100%) | 6 (100%) |
| 65 | 6 (100%) | 6 (100%) |
| 75 | 5 (83%) | 5 (83%) |
| 85 | 4 (67%) | 4 (67%) |
Across all 23 studies, recruiting or not: 26% stop at 75 or younger and 17% at 65; 52% take children; 0% are for women only and 0% for men only; 4% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 23 of 23. search them.
- Activation Sarcoma: PROMIS and Mobility Evaluation in Sarcoma PatientsRecruitingNCT072279612 countries
- TRACP-5b for Diagnosis and Follow-up of Giant Cell Tumor of BoneRecruitingNCT076092771 country
- Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of BoneRecruitingNCT03295981Phase 33 countries
- Accuracy of Indocyanine Green (ICG) Fluorescence Imaging in Giant Cell Tumor of Bone SurgeryRecruitingNCT07315828Phase 41 country
- Efficacy of ICG-based NIR Imaging in Intralesional Curettage of Giant Cell Tumors of Bone in Limbs: a Prospective, Single-center, Single-arm, Open StudyRecruitingNCT06647901Phase 1/21 country
- A Study to Evaluate the Efficacy and Safety of Narlumosbart (JMT103) in Patients With Giant Cell Tumor of BoneNot yet recruitingNCT05813665Phase 31 country
- Zoledronic Acid-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Bone Tumor After Intralesional CurettageRecruitingNCT05595603Phase 21 country
- LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue SarcomasActive, not recruitingNCT03449108Phase 21 country
- Study of XGEVA® (Denosumab) in Chinese Adults and Skeletally Mature Adolescents With Giant Cell Tumor of the BoneActive, not recruitingNCT04586660Phase 42 countries
- Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004CompletedNCT03301857Phase 48 countries
- Safety and Efficacy Study of Denosumab in Patients With Recurrent or Unresectable Giant Cell Tumor of BoneCompletedNCT00396279Phase 2
- Efficacy and Safety of JMT103 in Patients With Giant Cell Tumor of BoneStatus unknownNCT04255576Phase 1/21 country
- Study of Denosumab in Subjects With Giant Cell Tumor of BoneCompletedNCT00680992Phase 212 countries
- A Real-world Study on Patients of Unresectable Giant Cell Tumor of BoneCompletedNCT054028651 country
- The Value of Preoperative Diagnosis and Prognostic Prediction Based on Radiomics of Giant Cell Tumor of SpineCompletedNCT049528181 country
- Giant Cell Tumor of the Bone in Young PatientsCompletedNCT040028171 country
- Reduced Dose-density of Denosumab for Unresectable GCTBTerminatedNCT03620149Phase 24 countries
- Trial of Dasatinib in Advanced SarcomasCompletedNCT00464620Phase 21 country
- Safety and Efficacy of Post-operative Denosumab Strategy for Giant Cell Tumor of Bone Treatment in ChinaStatus unknownNCT03358212
- Characteristics and Mechanism of Denosumab-treated Giant Cell Tumor of BoneStatus unknownNCT03259152Phase 31 country
- Giant Cell Tumor of the Extremities Treated With Surgery and/or Medical TreatmentCompletedNCT02996734
- Adjuvant Zoledronic Acid in High Risk Giant Cell Tumour of Bone (GCT)TerminatedNCT00889590Phase 22 countries
- Study of the Effect of Zoledronate on Local Recurrence After Surgical Treatment of Giant Cell Tumors of Bone ZométaTerminatedNCT01564121Phase 1/21 country