Exocrine Pancreatic Insufficiency clinical trials
The registry lists 136 studies for Exocrine Pancreatic Insufficiency across more than 10 countries. 26 are recruiting or about to start. 65 of them are mainly about Exocrine Pancreatic Insufficiency (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-30. Counting its narrower condition Shwachman-Diamond Syndrome too: 155 studies, 29 open.
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Who runs them
Forest Laboratories (12) · Anthera Pharmaceuticals (8) · AbbVie (6) · Changhai Hospital (6) · Abbott (5) · Solvay Pharmaceuticals (5) · Digestive Care, Inc. (5) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (4)
What is being tested here
Drugs under test in Exocrine Pancreatic Insufficiency studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Apr 2027Evaluating the Efficacy of RELiZORB in Managing Exocrine Pancreatic Insufficiency in Tube-fed Pancreatitis Patients · Phase 3 · Massachusetts General Hospital
- Apr 2027PERT in Acute Necrotizing Pancreatitis · Phase 3 · Asian Institute of Gastroenterology, India
- Jun 2027Comparative Study to Evaluate Microbial Versus Porcine Pancreatic Enzyme Therapy in Chronic Pancreatitis · Phase 3 · Asian Institute of Gastroenterology, India
- Jun 2027Pancreatic Enzyme Replacement in Acute Necrotizing Pancreatitis · Phase 3 · Asian Institute of Gastroenterology, India
- Dec 2026Beta-cell Response to Incretin Hormones in Cystic Fibrosis · University of Pennsylvania
- Mar 2027A Study Of Effect Of Secretin For In Injection (Chirostim) On Pancreatic Fluid Composition In Healthy Subjects · Mayo Clinic
- Apr 2027Nutrition Intervention for Pancreatic Cancer · Children's Hospital of Philadelphia
- Apr 2027Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Jun 2027A Study to Evaluate Safety and Explore Efficacy of New Lipase NHS7108 in Adult Participants With Exocrine Pancreatic Insufficiency. · Aimmune Nestlé Health Science US R&D, LLC
- Jun 2027GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance · University of Pennsylvania
Who these studies take
Of the 19 Exocrine Pancreatic Insufficiency studies recruiting now, 12 (63%) set no upper age limit and 5 (26%) stop at 75 or younger. 5 (26%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (16%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (16%) | 3 (16%) |
| 18 | 19 (100%) | 19 (100%) |
| 30 | 19 (100%) | 19 (100%) |
| 40 | 19 (100%) | 19 (100%) |
| 50 | 19 (100%) | 19 (100%) |
| 65 | 16 (84%) | 16 (84%) |
| 75 | 14 (74%) | 14 (74%) |
| 85 | 13 (68%) | 13 (68%) |
Across all 136 studies, recruiting or not: 28% stop at 75 or younger and 21% at 65; 40% take children; 0% are for women only and 0% for men only; 10% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Exocrine Pancreatic Insufficiency studies take
Of 16 observational studies under Exocrine Pancreatic Insufficiency, half reached primary completion within 35 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Observational | 35 mo26–79 · 16 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting1
Studies
Recruiting first, then most recently updated. Showing 50 of 136. Browse all 136 → or search them.
- Phase 2 Study to Assess the Safety and Efficacy of ANG003RecruitingNCT07450547Phase 21 country
- Determine the Prevalence of Exocrine Pancreatic Insufficiency (EPI) in Pediatric and Adult Participants With Alagille Syndrome After Liver TransplantationRecruitingNCT073355231 country
- Comparative Study to Evaluate Microbial Versus Porcine Pancreatic Enzyme Therapy in Chronic PancreatitisRecruitingNCT07697352Phase 31 country
- A Study to Evaluate Safety and Explore Efficacy of New Lipase NHS7108 in Adult Participants With Exocrine Pancreatic Insufficiency.RecruitingNCT07559175Phase 27 countries
- Malabsorption Blood Test (MBT) to Determine Exocrine Pancreatic Function and Related Quality of Life in Chronic PancreatitisRecruitingNCT07418593Phase 41 country
- Dorzagliatin in Pancreatic Insufficient Cystic FibrosisRecruitingNCT06995651Phase 11 country
- A Study on the Efficacy of Different Doses of Oryz-Aspergillus Enzyme And Pancreatin Tablet in Treating Pancreatic Exocrine Insufficiency After Gastrointestinal SurgeryNot yet recruitingNCT07751367Not applicable1 country
- A Multicenter Clinical Study on Protein Absorption Efficiency in Patients With Pancreatic Exocrine Insufficiency in the ICUNot yet recruitingNCT07709611Phase 41 country
- Pancreatic Enzyme Replacement Therapy for Acute Pancreatitis-Associated Exocrine Pancreatic InsufficiencyRecruitingNCT06477159Phase 41 country
- GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose IntoleranceRecruitingNCT04731272Phase 21 country
- Evaluating the Efficacy of RELiZORB in Managing Exocrine Pancreatic Insufficiency in Tube-fed Pancreatitis PatientsRecruitingNCT06691893Phase 31 country
- Nutrition Intervention for Pancreatic CancerRecruitingNCT07554560Not applicable1 country
- Pancreatic Enzyme Replacement in Acute Necrotizing PancreatitisRecruitingNCT07441824Phase 31 country
- IPEX Study: Pancreatic Exocrine Insufficiency as a Functional Marker of Disease Progression in Patients With IPMNNot yet recruitingNCT07535125
- Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial PancreatectomyNot yet recruitingNCT074792381 country
- Assessment of Pancreatic Dysfunction in Patients With Type 2 DiabetesRecruitingNCT075129341 country
- Beta-cell Response to Incretin Hormones in Cystic FibrosisRecruitingNCT01851694Not applicable1 country
- PERT in Acute Necrotizing PancreatitisNot yet recruitingNCT07211568Phase 3
- Exocrine Pancreatic Insufficiency and Functional DyspepsiaNot yet recruitingNCT06756503
- Fatty Liver and Pancreatic SteatosisNot yet recruitingNCT067573481 country
- Shwachman-Diamond Syndrome Global Patient Survey and Partnering PlatformRecruitingNCT069999541 country
- Investigating Predictive Factors of Diabetes Occurence After DuodenalpancreatectomyRecruitingNCT021754591 country
- The Effect of PERT on Patients Undergoing PancreaticoduodenectomyRecruitingNCT06119880Phase 41 country
- Establishment and Clinical Application of Pancreatic Endocrine and Exocrine Function TestsRecruitingNCT060063121 country
- The Development of a Metabolomic Test to Diagnose and Quantify Pancreatic Exocrine Insufficiency (The DETECTION Study)RecruitingNCT05980221Not applicable1 country
- The Effects of Pancreatic Enzyme Supplementation in Critically Ill Patients on Enteral FeedingRecruitingNCT05112328Not applicable1 country
- A Study Of Effect Of Secretin For In Injection (Chirostim) On Pancreatic Fluid Composition In Healthy SubjectsActive, not recruitingNCT07285863Phase 41 country
- Evaluating the Utility of RELiZORB™ for Treating Feeding Intolerance in Critically Ill Adults With Multi-Organ FailureActive, not recruitingNCT05710315Not applicable1 country
- Safety of Stopping Pancreatic Enzyme Replacement Therapy in Children With Improved Pancreatic Function After Highly Effective Modulator TherapyCompletedNCT07632768Phase 41 country
- Registry of Pancreatic Exocrine Insufficiency: Enzyme Dose Requirements and Outcomes in Pancreatic Exocrine Insufficiency Across AetiologiesCompletedNCT054506271 country
- Phase 1 Study to Assess Safety and Efficacy of ANG003CompletedNCT06052293Phase 11 country
- Diagnosis and Treatment of Patients With Cystic FibrosisTerminatedNCT000012231 country
- Role of Pancreatic Exocrine Secretion in Weight Gain After Pancreas TransplantationSuspendedNCT046907381 country
- Genomic Resources for Enhancing Available Therapies (GREAT1.0) StudySuspendedNCT043069391 country
- Investigation on the Current Situation and Risk Factors Analysis of Exocrine Insufficiency in Chronic PancreatitisCompletedNCT069461081 country
- Longitudinal Assessment of Transient Elastography in Cystic FibrosisCompletedNCT030013882 countries
- Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic FibrosisCompletedNCT011445072 countries
- MRI to Characterize and Predict CF Liver Disease in PUSH CohortCompletedNCT029793401 country
- Medication Adherence to Phone-supervised Pancreatic Enzyme Replacement TherapyActive, not recruitingNCT06581653Not applicable1 country
- Magnesium Supplementation in Simultaneous Pancreas-Kidney TransplantationCompletedNCT067667861 country
- PERT to Improve Quality of Life in Patients Undergoing Pancreaticoduodenectomy: A Pilot Randomized Controlled TrialActive, not recruitingNCT05466838Not applicable1 country
- BÜHLMANN FPELA in the Diagnosis of Exocrine Pancreatic InsufficiencyCompletedNCT045487781 country
- Oral CDX-7108 in Healthy Adults and EPI SubjectsCompletedNCT05082051Phase 12 countries
- Study to Assess an Enteric Microgranule Formulation of Adrulipase in Patients With Cystic FibrosisCompletedNCT05719311Phase 21 country
- Diabetes/ Endocrine Surveillance in SDSTerminatedNCT042754791 country
- Study to Evaluate Symptoms of Exocrine Pancreatic Insufficiency in Adult Participants With Cystic Fibrosis or Chronic Pancreatitis Treated With CreonCompletedNCT05069597Phase 41 country
- Proton Pump Inhibitors (PPI) and Fat Absorption in Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (EPI)CompletedNCT03551691Phase 21 country
- Effect of CREON on Exocrine Pancreatic Insufficiency (EPI) SymptomsCompletedNCT049498281 country
- AI Evaluation of Pancreatic Exocrine Insufficiency in CP PatientsCompletedNCT062782721 country
- A Study to Compare US Marketed Creon Manufactured With a Modernized Process at an Alternate Manufacturing Site and Manufactured With the Approved Manufacturing Process at an Alternate Active Pharmaceutical Ingredient Site, in Participants With Exocrine Pancreatic Insufficiency Due to Cystic FibrosisCompletedNCT03924947Phase 41 country