Directly Observed Therapy clinical trials

The registry lists 34 studies for Directly Observed Therapy across more than 10 countries. 4 are recruiting or about to start. 4 of them are mainly about Directly Observed Therapy (how this is decided). Per ClinicalTrials.gov, last updated 2026-07-02.

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Status

Completed: 25
Terminated: 3
Not yet recruiting: 2
Recruiting: 2
Status unknown: 2

Phase

Phase 2: 7
Phase 4: 3
Phase 3: 3
Early Phase 1: 1

Where

United States: 16
South Africa: 3
India: 3
Turkey: 2
Switzerland: 1
Armenia: 1

Who runs them

National Institute of Allergy and Infectious Diseases (NIAID) (4) · Johns Hopkins University (2) · Prisma Health-Upstate (2) · Universidad de Burgos (2) · Albert Einstein College of Medicine (2) · AiCure (2) · Johns Hopkins Bloomberg School of Public Health (2) · University of California, San Diego (1)

What is being tested here

Drugs under test in Directly Observed Therapy studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Terazosin	1	0	1
Peginterferon alfa-2a	0	1	2
Varenicline	0	0	1
Fluoxetine	0	0	1
Emtricitabine tenofovir alafenamide	0	0	1

Coming up

1phase 3 study under way

0studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

Who these studies take

Of the 2 Directly Observed Therapy studies recruiting now, 0 (0%) set no upper age limit and 2 (100%) stop at 75 or younger. 1 (50%) take children under 18. 0 (0%) are for women only and 1 (50%) for men only; 0 (0%) take healthy volunteers.

Recruiting studies that take each age, of 2
Age	Women	Men
10	1 (50%)	1 (50%)
18	0 (0%)	1 (50%)
30	0 (0%)	1 (50%)
40	0 (0%)	1 (50%)
50	0 (0%)	1 (50%)
65	0 (0%)	1 (50%)
75	0 (0%)	1 (50%)
85	0 (0%)	0 (0%)

Across all 34 studies, recruiting or not: 21% stop at 75 or younger and 15% at 65; 29% take children; 0% are for women only and 6% for men only; 15% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Directly Observed Therapy studies take

Of 13 interventional studies with no phase under Directly Observed Therapy, half reached primary completion within 19 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Interventional, no phase	19 mo13–42 · 13 studies	—	—

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

Studies

Recruiting first, then most recently updated. Showing 34 of 34. search them.