Depressive Disorder, Major: all 2,805 studies

Page 17 of 29. Open to participants first (565), then studies with results posted, then the rest; newest registration first within each.

• TDCS in Pediatric and Teenage Patients With Major Depressive Disorder During COVID-19 PandemicStatus unknownNCT04780152Phase 2/3
• Probiotics and the Gut Brain Axis- Do Probiotics Interact With the Vagal Nerve?CompletedNCT04772664Not applicable
• Evaluate the Quality of Life and Treatment of Anxiety Symptoms of Buspirone in Patients With Depression Disorders(BASIS)CompletedNCT04770454
• Behavioral Activation for Major Depression With and Without MindfulnessCompletedNCT04768361Not applicable
• Antidepressant Decision Aid for Major Depressive Disorder PatientsCompletedNCT04761757Not applicable
• The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder PatientsWithdrawnNCT04751071Phase 1/2
• Tracking Response to Antidepressants in Advance of Investigational TrialsStatus unknownNCT04748276
• Incorporating Stepped Care Approach Into e-CBT for DepressionCompletedNCT04747873Not applicable
• The Effects of the Be Mindful Intervention in Previously Depressed Individuals Experiencing Subclinical SymptomsCompletedNCT04740879Not applicable
• Feasibility and Acceptability of a Healthy Nordic Diet Intervention in Depressed and Non-depressed AdultsCompletedNCT04731454Not applicable
• Stellate Ganglion Block for Major Depressive Disorder.CompletedNCT04727229Phase 4
• ANTIVIRAL TREATMENT OF CYTOMEGALOVIRUS IN DEPRESSIONCompletedNCT04724447Phase 1/2
• Internet-administered Interpersonal Psychotherapy for Depressive SymptomsCompletedNCT04721678Not applicable
• D-serine Supplementation for DepressionCompletedNCT04721249Not applicable
• The Efficacy and Safety of tDCS in Patients With Mild to Moderate Major Depressive DisorderCompletedNCT04720040Not applicable
• The Modulatory Role of Communicated Treatment Rationale on Treatment Expectation Effects in Depression.CompletedNCT04719663Not applicable
• Cognitive Behavioral Therapy Group for Older Adults Delivered by TelethealthTerminatedNCT04714164Not applicable
• Fixed Order, Open-Label, Dose-Escalation Study of DMT in HumansActive, not recruitingNCT04711915Phase 1
• Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in DepressionCompletedNCT04701866Not applicable
• Clinical Study of GH001 in DepressionCompletedNCT04698603Phase 1/2
• Aerobic Group Exercise for Adolescents With DepressionCompletedNCT04695145Not applicable
• Brainsway DTMS for Treatment of MDD Using iTBSCompletedNCT04679753Phase 4
• Using mHealth to Improve Adherence and Reduce Blood Pressure in Individuals With Hypertension and Mood DisordersCompletedNCT04675593Not applicable
• SPL026 (DMT Fumarate) in Healthy Subjects and MDD PatientsCompletedNCT04673383Phase 1/2
• A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of SuicideCompletedNCT04669665Phase 2
• Dexmedetomidine Adjuvant Treatment for Depressed Patients Undergoing ECTStatus unknownNCT04661475Phase 4
• Optimisation of ECT Based on ASTI vs NarcotrendCompletedNCT04657575Not applicable
• "Brexpiprazole (Rexulti™) Safety and Efficacy Among Filipino Patients (RAISE) - A Post Marketing Surveillance Program"Status unknownNCT04641780
• Supportive Text Messaging Versus Supportive E-mail Messaging for Patients with Major Depressive DisorderCompletedNCT04638231Not applicable
• The Efficacy of Automated Feedback After Internet-based Depression ScreeningCompletedNCT04633096Not applicable
• Investigating Biological Markers, Targets, and Intervention for Mood DisordersTerminatedNCT04632498Not applicable
• The Effect of Psilocybin on MDD Symptom Severity and Synaptic DensityCompletedNCT04630964Phase 2
• IPT for Major Depression Following Perinatal Loss: Healing After Loss (HeAL)CompletedNCT04629599Not applicable
• the Safety, Tolerability, and Pharmacokinetics Study of HEC113995CompletedNCT04623814Phase 1
• Evaluation of the Safety and Pharmacokinetics of MSI-195 to a Commercial S-AdenosylmethionineCompletedNCT04623034Phase 1
• Pilot Study of the Safety and Tolerability of L-DLPFC iTBS rTMS for MDD in MSStatus unknownNCT04621708Not applicable
• Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use DisorderActive, not recruitingNCT04620759Phase 2
• Near-infrared Radiation-transcranial Photobiomodulation for Major Depressive DisorderCompletedNCT04619121Not applicable
• Safety and Tolerability of Single and Multiple Ascending Doses of GATE-101 in Normal Human VolunteersTerminatedNCT04618263Phase 1
• Clinical Validation of a Combinatorial Pharmacogenomic Approach in Major Depressive DisorderStatus unknownNCT04615234
• Interactive Voice-Based Administration of the PHQ-9Status unknownNCT04609267Not applicable
• Mechanistic Evaluation of Response in TRD (MERIT)CompletedNCT04608396Phase 2
• Effects of Respiratory-Gated Transcutaneous Vagal Nerve Stimulation in Major Depression (Phase 1)CompletedNCT04607226Not applicable
• Symptom-specific TMS Targets for Depression and AnxietyCompletedNCT04604210Phase 2
• The Safety, Efficacy, and Tolerability of Microbial Ecosystem Therapeutic-2 in People With Major DepressionStatus unknownNCT04602715Phase 2
• Tolerability and Pharmacokinetics of Hypidone Hydrochloride in Healthy SubjectsCompletedNCT04598607Phase 1
• Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD)WithdrawnNCT04594616Not applicable
• The Safety and Efficacy of Psilocybin in Cancer Patients With Major Depressive DisorderStatus unknownNCT04593563Phase 2
• Action Tendencies and Prognosis in Major Depressive DisorderCompletedNCT04593537
• The Safety, Tolerability, and Pharmacokinetics Study of HEC113995 PA•H2O Tablets in Healthy SubjectsCompletedNCT04591301Phase 1
• A Double-blind, Placebo-controlled Study of Antidepressant Augmentation With AgomelatineCompletedNCT04589143Phase 4
• Using EEG to Predict Depression Treatment Response to rTMS in Patients With Major DepressionWithdrawnNCT04575285
• Gender Dysphoria: Epidemiological DataStatus unknownNCT04573127
• Efficacy of Blue Light Treatment in Patients With Nonseasonal Major Depressive DisorderStatus unknownNCT04555408Not applicable
• Individualized Targeting and Neuromodulation of Late-Life DepressionActive, not recruitingNCT04543773Not applicable
• Effect of Self-administered tDCS in Patients With MDDCompletedNCT04543123Phase 4
• Fisher Wallace Neurostimulation & Depression StudyActive, not recruitingNCT04541563Not applicable
• Efficacy of Pythagorean Self-Awareness Intervention for Major Depressive DisorderCompletedNCT04536714Not applicable
• PKC as Serum Biomarkers for DepressionStatus unknownNCT04531423Not applicable
• The Efficacy and Prediction of Deep Brain Stimulation for Treatment-resistant DepressionActive, not recruitingNCT04530942Not applicable
• Patient Characteristics and Cognitive vs. Behavioral Therapies for DepressionCompletedNCT04529694Not applicable
• Optimization of Diagnosis and Treatment of Depression Based on Multidimensional Clinical Assessment ClassificationStatus unknownNCT04528628Not applicable
• The Utility of Concurrent TBS/fNIRS for Antidepressant Treatment OptimizationCompletedNCT04526002Not applicable
• A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant TherapyCompletedNCT04513912Phase 3
• Scaling Mental Healthcare in COVID-19 With Voice BiomarkersCompletedNCT04510519
• Bear Bile Pill as add-on the Treatment of MDDStatus unknownNCT04509882Phase 2
• Transcranial Direct Current Stimulation (tDCS) Therapy in Major DepressionCompletedNCT04507243Not applicable
• Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal IdeationCompletedNCT04502758Not applicable
• Vortioxetine for Treatment of Depressive Mood and Alcohol UseStatus unknownNCT04498897Phase 2
• Efficacy of Transcranial Direct Current Stimulation (tDCS) for the Treatment of Major Depressive DisorderStatus unknownNCT04497493Not applicable
• Transcranial Magnetic Stimulation vs Theta Burst Stimulation in Major Depressive DisorderStatus unknownNCT04497350Not applicable
• Neuromodulation Device Use in Patients With Major Depressive DisorderWithdrawnNCT04496505Not applicable
• Accelerated Bilateral rTMS on Geriatric DepressionTerminatedNCT04486222Not applicable
• Effect of Zinc Supplementation on Depression in SSRI-treated Major Depressive Disorder PatientsCompletedNCT04482296Not applicable
• Peer-delivered and Technology-Assisted Integrated Illness Management and RecoveryCompletedNCT04481737Not applicable
• Feasibility and Effectiveness of Delivering CBT Through OPTT for DepressionCompletedNCT04478058Not applicable
• Ketamine or Placebo in Patients With Major Depression and Advanced CancerCompletedNCT04471818Phase 1/2
• Dopaminergic Dysfunction in Late-Life DepressionCompletedNCT04469959Phase 2
• Establishing TCM Daycare Model and Teaching Mechanism of Depression PatientsStatus unknownNCT04469608Not applicable
• Pharmacogenetic Implementation Trial in Veterans With Treatment Refractory DepressionCompletedNCT04469322Not applicable
• Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive DisorderCompletedNCT04466345Phase 2
• A Study to Describe Routine Treatment Pathways in Participants With Major Depression and Active Suicidal Ideation With Intent in ItalyCompletedNCT04463108
• Psychophysiological Study of Pain Perception in Depressed Patients With Suicidal RiskTerminatedNCT04461327Not applicable
• Combining H1-Coil Deep Transcranial Magnetic Stimulation (dTMS) and App-guided CBT in Subjects With Major Depression Disorder (MDD)Status unknownNCT04455646
• A Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Participants With Major Depressive DisorderCompletedNCT04451187Phase 1
• Comparison of Vortioxetine and Desvenlafaxine in Adult Patients Suffering From DepressionCompletedNCT04448431Phase 4
• Light Therapy to Improve Symptoms in Pregnant Women With Major Depressive DisorderStatus unknownNCT04447430Not applicable
• Brain Hippocampal Volume Relationship With Anxious Symptoms in Major Depressive PatientsStatus unknownNCT04430556Not applicable
• tDCS Intervention on Motivational Anhedonia of Major Depressive DisorderStatus unknownNCT04425278Not applicable
• Neuroinflammation, Affective and Cognitive Symptoms in Major Depression and PsoriasisWithdrawnNCT04423471
• Combination of Novel Therapies for CKD Comorbid DepressionActive, not recruitingNCT04422652Phase 2
• Mental Health Assessment and Prescribing by Alberta PharmacistsCompletedNCT04410575Not applicable
• The DPP-4 Inhibitor Vildagliptin as Adjunct in Major Depressive Disorder PatientsWithdrawnNCT04410341Phase 1/2
• Efficacy of Clinical Application of Transcranial Low Intensity Focused Ultrasonic Stimulation for Patients With Major Deperessive Disorder - Exploratory Clinical TrialCompletedNCT04405791Phase 3
• Effectiveness of Walking Exercise in Improving Depression in Older Adults With Major Depressive Disorder, A Pilot StudyCompletedNCT04403373Not applicable
• The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT)Status unknownNCT04399070Not applicable
• Treatment of Major Depressive Disorder With Bilateral Theta Burst StimulationCompletedNCT04392947Not applicable
• Stress Management and Resiliency Training for Depression vs Treatment as Usual in the Treatment of Major DepressionCompletedNCT04388748Not applicable
• Leveraging EEG for Antidepressant Prediction With Sertraline and EscitalopramWithdrawnNCT04388202Phase 4
• Leveraging EEG for Antidepressant Prediction With Duloxetine and BupropionWithdrawnNCT04388189Phase 4

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