Corneal Endothelial Cell Loss clinical trials
The registry lists 28 studies for Corneal Endothelial Cell Loss across more than 10 countries. 6 are recruiting or about to start. 21 of them are mainly about Corneal Endothelial Cell Loss (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-09.
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Who runs them
Cairo University (3) · Sunnybrook Health Sciences Centre (3) · Assiut University (2) · Topcon Medical Systems, Inc. (2) · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (1) · Centre Hospitalier Régional Metz-Thionville (1) · University of Erlangen-Nürnberg Medical School (1) · Emmecell (1)
What is being tested here
Drugs under test in Corneal Endothelial Cell Loss studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ascorbic Acid | 2 | 0 | 2 |
| EO2002 | 1 | 0 | 1 |
| K-115 | 0 | 0 | 1 |
| Sulfur Hexafluoride | 0 | 0 | 1 |
| Dexamethasone | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
- Jan 2027A Study of CA201A Eye Drops to Prevent Corneal Endothelial Cell Loss in Patients Undergoing Cataract Surgery · Caravel Oculus Pty Ltd
- Aug 2027Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction · Emmecell
Who these studies take
Of the 6 Corneal Endothelial Cell Loss studies recruiting now, 4 (67%) set no upper age limit and 0 (0%) stop at 75 or younger. 1 (17%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 4 (67%) | 4 (67%) |
| 30 | 5 (83%) | 5 (83%) |
| 40 | 5 (83%) | 5 (83%) |
| 50 | 5 (83%) | 5 (83%) |
| 65 | 6 (100%) | 6 (100%) |
| 75 | 6 (100%) | 6 (100%) |
| 85 | 6 (100%) | 6 (100%) |
Across all 28 studies, recruiting or not: 18% stop at 75 or younger and 4% at 65; 11% take children; 0% are for women only and 0% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 28 of 28. search them.
- Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial DysfunctionRecruitingNCT07729137Phase 21 country
- A Study of CA201A Eye Drops to Prevent Corneal Endothelial Cell Loss in Patients Undergoing Cataract SurgeryRecruitingNCT07694375Phase 21 country
- Safety and Tolerability of EO2002RecruitingNCT05587205Phase 11 country
- The Viability Control of Human Endothelial Cells Before Keratoplasty (V-CHECK) StudyRecruitingNCT058473876 countries
- Effect of Vitamin C Supplementation in Corneal Endothelial Damage in Phacoemulsification of Patients with Hard CataractsRecruitingNCT06781970Not applicable1 country
- Anterior Chamber Versus Scleral Fixated Intraocular Lens: Long-term Vision and Safety OutcomesRecruitingNCT040729781 country
- Effect of Systemic Ozone Therapy on Corneal EndotheliumCompletedNCT07718100Not applicable1 country
- Comparison of Phacoemulsification and Corneal Damage Between FLACS and Standard Phaco With Two HandpiecesWithdrawnNCT05119270Not applicable1 country
- RTA 408 Ophthalmic Suspension for the Prevention of Corneal Endothelial Cell Loss Following Cataract Surgery - GUARDCompletedNCT02128113Phase 21 country
- Anterior Versus Posterior Artisan Intraocular Lens Fixation in Aphakic Children With Insufficient Capsular Support.CompletedNCT06396156Not applicable1 country
- Corneal Endothelial Cell Loss After Trabeculectomy Versus PhakotrabeculectomyCompletedNCT03107000Not applicable1 country
- Corneal Endothelium in Diabetics Undergoing PhacoemulsificationStatus unknownNCT05522842
- Corneal Endothelium After Phacoemulsification in Pseudo Exfoliation SyndromeCompletedNCT05447130Not applicable1 country
- Quantification of Factors Influencing Endothelial Damage During PhacoemulsificationCompletedNCT055294851 country
- Comparative Study of Specular Microscopes for Endothelial and Corneal Cell MeasurementsCompletedNCT021382661 country
- Second Comparative Study of Specular Microscopes for Endothelial and Corneal Cell MeasurementsCompletedNCT024272561 country
- Endothelial Changes in Pseudoexfoliation SyndromeStatus unknownNCT05194891
- Changes in Corneal Endothelial Cell Density After Transscleral ab Interno Glaucoma Gel Stent ImplantationCompletedNCT045470361 country
- Technique And Results In Endothelial KeratoplastyCompletedNCT02470793Not applicable1 country
- Effect of Intracameral Injection of Mydriatic Plus Anaesthetic Combination on Corneal Endothelial Count in PhacoCompletedNCT04396301Phase 31 country
- Effect of Intracameral Dexamethasone After Phacoemulsification in Diabetics on Corneal Endothelial Cell DensityWithdrawnNCT03361709Phase 4
- Comparative Study of Specular Microscopes for Measurements of Cell Density, Coefficient of Variation and HexagonalityCompletedNCT022766381 country
- Protecting the Corneal Endothelium During Cataract Surgery Using the Anterior CapsuleCompletedNCT03855293Not applicable
- Ripasudil 0.4% Eye Drops in Fuchs Endothelial Corneal DystrophyStatus unknownNCT03575130Phase 21 country
- Endothelial Cell Loss After Cataract SurgeryTerminatedNCT00932191Phase 2/31 country
- Corneal Endothelial Cell Loss After Pneumatic Retinopexy for the Repair of Primary Rhegmatogenous Retinal DetachmentStatus unknownNCT02185469Not applicable1 country
- Effect of Intravitreal Bevacizumab on Corneal EndotheliumStatus unknownNCT017267901 country
- The Effect of Hydrodynamic Parameters on Corneal Endothelial Cell Loss After PhacoemulsificationCompletedNCT00370955Not applicable1 country