Carcinoma, Pancreatic Ductal clinical trials
The registry lists 57 studies for Carcinoma, Pancreatic Ductal across more than 10 countries. 10 are recruiting or about to start. 34 of them are mainly about Carcinoma, Pancreatic Ductal (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-13.
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Who runs them
Revolution Medicines, Inc. (4) · Pfizer (4) · University Health Network, Toronto (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Angiodynamics, Inc. (2) · Sumitomo Pharma America, Inc. (2) · Halozyme Therapeutics (2) · Fudan University (2)
Who develops what
Every programme with a company-led study here in the last two years, whatever its size: 4 programmes from 3 companies, 2 with this as their studies’ main aim; 0 with a live phase 3 study; 2 primary completions in the next 12 months.
Stage, biomarker and line of therapy are not read yet: these programmes are in development here, not all in the same competitive position.
Comparator & background therapies
What other companies’ phase 2+ studies give as the comparator or the background here (its leading trial sponsor and partners left out): a sign of what new drugs are measured against, not by itself the standard of care, its prescriptions or its market.
| Drug | Leading trial sponsor | Companies, last 5 years |
|---|---|---|
Modified FOLFIRINOX RegimenRecent, limitedEvidence
| — | 11 study |
GemcitabineRecent, limitedPhase 4 trial recordedEvidence
| Eli Lilly and Company30% of its industry studies | 11 study |
Albumin-Bound PaclitaxelRecent, limitedPhase 4 trial recordedEvidence
| Bristol-Myers Squibb44% of its industry studies | 11 study |
3 more in limited or earlier use — sign in to see them, free.
Programmes
“Meets, by arms” reads each study’s arms: vs its arm against the therapy’s; + X vs a combination against it; added to it plus the therapy against the therapy; studied with given together only. The next primary completion is the next phase-3 study’s when there is one.
The 4 programmes — sign in to see the whole list, free: filter by phase and aim, sort by late development, direct comparisons or the next primary completion.
Primary completion in the next 12 months (2)
Live phase 2 and 3 studies of these programmes. Primary completion is when the main measure’s data collection ends, as the registry states it (most are estimates); results come later, if they are announced.
- 15 Dec 2026 est.Acoustic Cluster Therapy · EXACT Therapeutics AS · Phase 2 registry mapping onlyNCT06850623 Acoustic Cluster Therapy (ACT) With Chemotherapy for the Treatment of Locally Advanced Pancreatic Cancer — primary endpoint: ORR (Overall response rate), defined as the number of participants with measurable disease at baseline who have a confirmed Complete Response or confirmed Partial Response according to RECIST Version 1.1. · 25 enrolled
- Sep 2027 est.relacorilant · Corcept Therapeutics · Phase 2 main aimNCT07259317 Relacorilant With Nab-Paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Adenocarcinoma — primary endpoint: Percent of Patients who Experience Dose Limiting Toxicity (DLT) (Part 1) · 80 enrolled
Read from ClinicalTrials.gov, industry-led studies. Main aim: this is the study’s judged main condition; named, not the main aim: the sponsor names it, the study is about something else; registry mapping only: only the registry’s mapping put it here. Leading trial sponsor is the company leading the most industry studies of a drug, a measure of trial activity, not of rights. Phase 4 trial recorded: a phase 4 study exists somewhere; approval here is not checked. Not read yet: approvals and labels, exclusivity, licences, line of therapy, academic comparators, sales.
What is being tested here
Drugs under test in Carcinoma, Pancreatic Ductal studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Daraxonrasib | 3 | 0 | 3 |
| Sitneprotafib | 1 | 0 | 3 |
| Elironrasib | 1 | 0 | 2 |
| Paclitaxel | 1 | 0 | 2 |
| Gemcitabine | 1 | 0 | 2 |
| Relacorilant | 1 | 0 | 1 |
| Albumin-Bound Paclitaxel | 1 | 0 | 1 |
| Cetuximab | 1 | 0 | 1 |
| Zoldonrasib | 1 | 0 | 1 |
| Glecirasib | 1 | 0 | 1 |
Drug classes tested here Antimitotic agents 2 open · Antimetabolites 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Dec 2026Acoustic Cluster Therapy (ACT) With Chemotherapy for the Treatment of Locally Advanced Pancreatic Cancer · EXACT Therapeutics AS
- Mar 2027Phase 1/2a Study of JAB-21822 Plus JAB-3312 in Patients With Advanced Solid Tumors Harboring KRAS p.G12C Mutation · Allist Pharmaceuticals, Inc.
- Mar 2027Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors · Revolution Medicines, Inc.
- May 2027Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS · Revolution Medicines, Inc.
- Sep 2027Relacorilant With Nab-Paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Adenocarcinoma · Corcept Therapeutics
Who these studies take
Of the 7 Carcinoma, Pancreatic Ductal studies recruiting now, 7 (100%) set no upper age limit and 0 (0%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 7 (100%) | 7 (100%) |
| 30 | 7 (100%) | 7 (100%) |
| 40 | 7 (100%) | 7 (100%) |
| 50 | 7 (100%) | 7 (100%) |
| 65 | 7 (100%) | 7 (100%) |
| 75 | 7 (100%) | 7 (100%) |
| 85 | 7 (100%) | 7 (100%) |
Across all 57 studies, recruiting or not: 12% stop at 75 or younger and 0% at 65; 5% take children; 0% are for women only and 0% for men only; 4% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 57. Browse all 57 → or search them.
- Acoustic Cluster Therapy (ACT) With Chemotherapy for the Treatment of Locally Advanced Pancreatic CancerRecruitingNCT06850623Phase 22 countries
- Relacorilant With Nab-Paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic AdenocarcinomaRecruitingNCT07259317Phase 21 country
- Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid TumorsRecruitingNCT06445062Phase 1/21 country
- Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid TumorsRecruitingNCT06128551Phase 1/27 countries
- Phase 1/2a Study of JAB-21822 Plus JAB-3312 in Patients With Advanced Solid Tumors Harboring KRAS p.G12C MutationRecruitingNCT05288205Phase 1/21 country
- Using Tumor Models to Determine TreatmentsRecruitingNCT06813079Phase 21 country
- Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RASRecruitingNCT05379985Phase 1/21 country
- CD318-targeted CAR-T Cell Therapy in Patients With Pancreatic Cancer (ResCPa)Not yet recruitingNCT07153289Phase 1/2
- Radiotherapy With Sequential Chemotherapy Combined With PD-1 Inhibitor and Thymalfasin for BRPCNot yet recruitingNCT06573398Phase 2
- A Cohort Study on Screening and Follow-up of High-risk Population of PDAC Based on EUSNot yet recruitingNCT05621824
- A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.Active, not recruitingNCT06447662Phase 12 countries
- Personalized First-line Chemotherapy Choice in Advanced Pancreatic Adenocarcinoma Using Transcriptomic SignaturesActive, not recruitingNCT05475366Not applicable1 country
- Hepatic Artery Infusional Floxuridine to Treat Pancreatic Cancer Liver MetastasesActive, not recruitingNCT03856658Phase 21 country
- A Study to Learn About the Study Medicine PF-07985045 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Change in a Gene.TerminatedNCT06704724Phase 12 countries
- Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid TumorsActive, not recruitingNCT05462717Phase 113 countries
- A Clinical Trial of PF-08046037 Alone or With Sasanlimab in Patients With Advanced or Metastatic MalignanciesTerminatedNCT06974734Phase 12 countries
- Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)CompletedNCT054614301 country
- A First-in-Human, Phase 1 Study of JAB-3312 in Adult Patients With Advanced Solid TumorsCompletedNCT04045496Phase 11 country
- Study of Changes and Characteristics of Genes in Patients With Pancreatic Cancer for Better Treatment SelectionCompletedNCT027506571 country
- A Study of MGC018 in Combination With MGD019 in Participants With Advanced Solid TumorsCompletedNCT05293496Phase 11 country
- A Study of JAB-3312 in Adult Patients With Advanced Solid Tumors in ChinaCompletedNCT04121286Phase 11 country
- A Registry Study of NanoKnife IRE for Stage 3 Pancreatic CancerActive, not recruitingNCT038996491 country
- A Pivotal Study of Safety and Effectiveness of NanoKnife IRE for Stage 3 Pancreatic CancerActive, not recruitingNCT03899636Phase 31 country
- An Evaluation of the Utility of the ExSpiron Respiratory Variation Monitor During Upper GI EndoscopyCompletedNCT02310230Not applicable1 country
- A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Pancreatic CancerCompletedNCT02231723Phase 11 country
- Recurrence After Whipple's (RAW) StudyCompletedNCT045968658 countries
- A Study of Napabucasin Plus Nab-Paclitaxel With Gemcitabine in Adult Patients With Metastatic Pancreatic AdenocarcinomaCompletedNCT02993731Phase 320 countries
- Impact of Nationwide Enhanced Implementation of Best Practices in Pancreatic Cancer Care (PACAP-1)CompletedNCT03513705Not applicable1 country
- Selective Extended Dissection in Different Types of Pancreatic Head Cancer: A Retrospective Cohort Study.CompletedNCT057239781 country
- Ultrasound-enhanced Uptake of Chemotherapy in Patients With Inoperable Pancreatic Ductal AdenocarcinomaCompletedNCT04146441Phase 21 country
- Parvovirus H-1 (ParvOryx) in Patients With Metastatic Inoperable Pancreatic CancerCompletedNCT02653313Phase 1/21 country
- Predictive Factors for Resection and Survival in Type A Borderline Resectable Pancreatic Ductal Adenocarcinoma Patients After Neoadjuvant TherapyStatus unknownNCT05489458
- EUS Shear Wave for Solid Pancreatic Lesions.Status unknownNCT050958311 country
- The Combination Chemotherapy of SIRIOX as First- or Second-Line Chemotherapy for Pancreatic CancerStatus unknownNCT03403101Phase 21 country
- Establishing Organoids From Metastatic Pancreatic Cancer Patients, the OPT-I Study.Status unknownNCT03500068Not applicable1 country
- Efficacy Study of Gemcitabine, Paclitaxel, and Irradiation in the Treatment of Pancreatic CancerWithdrawnNCT00226746Phase 21 country
- Durvalumab and Tremelimumab in Combination With First-Line Chemotherapy in Advanced Solid TumorsCompletedNCT02658214Phase 12 countries
- PEGPH20 Plus Nab-Paclitaxel Plus Gemcitabine Compared With Nab-Paclitaxel Plus Gemcitabine in Participants With Stage IV Untreated Pancreatic CancerCompletedNCT01839487Phase 21 country
- A Study of PEGylated Recombinant Human Hyaluronidase in Combination With Nab-Paclitaxel Plus Gemcitabine Compared With Placebo Plus Nab-Paclitaxel and Gemcitabine in Participants With Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal AdenocarcinomaTerminatedNCT02715804Phase 322 countries
- Amatuximab for High Mesothelin CancersTerminatedNCT01413451Early Phase 11 country
- A Phase 1 Study of CC-486 as a Single Agent and in Combination With Carboplatin or ABI-007 in Subjects With Relapsed or Refractory Solid TumorsCompletedNCT01478685Phase 14 countries
- Correlation of Serum CA19-9 Levels With Levels in Saliva and Urine of Patients With Ductal Adenocarcinoma of the PancreasStatus unknownNCT02817308Not applicable1 country
- Detection of MicroRNA-25 in the Diagnosis of Pancreatic CancerStatus unknownNCT034326241 country
- Pancreatic Cancer Can be Detected by Adrenomedullin in New Onset Diabetes PatientsTerminatedNCT024560511 country
- QUILT-3.019: Phase 2 Study of NPC-1C Chimeric Monoclonal Antibody to Treat Pancreatic and Colorectal CancerCompletedNCT01040000Phase 1/21 country
- A Study of AGS-1C4D4 in Pancreatic Cancer Subjects Previously Treated in Protocol 2008002CompletedNCT01608711Phase 22 countries
- Phase II Study of Preoperative FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel in Patients With Resectable Pancreatic CancerTerminatedNCT02243007Phase 21 country
- Continuous Monitoring on the General WardCompletedNCT02933307Not applicable
- Standard Versus Extended Lymphadenectomy in Pancreatoduodenectomy for Patients With Pancreatic Head AdenocarcinomaStatus unknownNCT02928081Not applicable1 country
- Atu027 Plus Gemcitabine in Advanced or Metastatic Pancreatic Cancer (Atu027-I-02)CompletedNCT01808638Phase 1/21 country