alpha-Mannosidosis clinical trials

The registry lists 24 studies for alpha-Mannosidosis across more than 10 countries. 6 are recruiting or about to start. 15 of them are mainly about alpha-Mannosidosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-03.

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Status

Completed: 11
Recruiting: 5
Terminated: 3
Withdrawn: 2
Available: 1
Active, not recruiting: 1

Phase

Phase 2: 8
Phase 3: 6
Phase 1: 3

Where

United States: 12
Denmark: 6
Germany: 4
United Kingdom: 3
France: 3
Austria: 1

Who runs them

Zymenex A/S (6) · Chiesi Farmaceutici S.p.A. (6) · Masonic Cancer Center, University of Minnesota (3) · Paul Szabolcs (2) · Joanne Kurtzberg, MD (1) · University of Pittsburgh (1) · Talaris Therapeutics Inc. (1) · Greenwood Genetic Center (1)

What is being tested here

Drugs under test in alpha-Mannosidosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Alemtuzumab	1	0	3
Hydroxyurea	1	0	1
Fludarabine	1	0	1
Melphalan	1	0	1
Thiotepa	1	0	1
Velmanase alfa	0	5	9
Cyclophosphamide	0	0	2
Busulfan	0	0	2
Cyclosporine	0	0	1
Mycophenolic Acid	0	0	1

Drug classes tested here Alkylating agents 1 open

Coming up

0phase 3 studies under way

2studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 2

Nov 2026Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT · Paul Szabolcs
Oct 2027UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells · Joanne Kurtzberg, MD

Who these studies take

Of the 5 alpha-Mannosidosis studies recruiting now, 1 (20%) set no upper age limit and 4 (80%) stop at 75 or younger. 5 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.

Recruiting studies that take each age, of 5
Age	Women	Men
10	4 (80%)	4 (80%)
18	4 (80%)	4 (80%)
30	3 (60%)	3 (60%)
40	3 (60%)	3 (60%)
50	3 (60%)	3 (60%)
65	1 (20%)	1 (20%)
75	1 (20%)	1 (20%)
85	1 (20%)	1 (20%)

Across all 24 studies, recruiting or not: 58% stop at 75 or younger and 58% at 65; 100% take children; 0% are for women only and 0% for men only; 0% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

Studies

Recruiting first, then most recently updated. Showing 24 of 24. search them.