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CompletedNCT07925372APCVOUpdated Nov 9, 2026

Acute Pain Management of Vaso-occlusive Crises in Pediatric Patients With Sickle Cell Disease in the Emergency Department: a Comparative Study.

An observational study in Sickle Cell Disease, sponsored by Central Hospital, Nancy, France. Completed at 3 sites in France. Open to participants aged 0 Years to 17 Years. Per ClinicalTrials.gov, last updated 2026-11-09.

Sponsored by Central Hospital, Nancy, France · Observational

Updated Nov 9, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
92
Ages
0 Years to 17 Years
Sex
All
01

Study summary

This retrospective observational multicenter study aims to describe the management of acute pain in children with sickle cell disease treated in the emergency departments of the University Hospitals of Nancy, Strasbourg, and Reims, France. The study analyzed routinely collected medical data from pediatric patients presenting with acute painful episodes related to sickle cell disease. Information regarding pain assessment, analgesic treatment, timing of care, and clinical outcomes was reviewed. No additional procedures or interventions were performed for the purpose of this study. All data were collected as part of standard clinical care. The results of this study may help improve the management of acute pain in children with sickle cell disease in emergency settings.

02

Conditions studied

  • Sickle Cell Disease

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03

In context

Anemia, Sickle Cell

1,134 studies on the registry are indexed under Anemia, Sickle Cell; 238 are open to participants now.

This study's enrollment of 92 is close to the median of 100 across 296 observational studies indexed under Anemia, Sickle Cell.

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Lead sponsor

Central Hospital, Nancy, France is the lead sponsor of 798 studies on the registry; 186 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
0 Years to 17 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Pediatric patients aged 0 to 17 years with confirmed sickle cell disease presenting to the emergency department for a painful vaso-occlusive crisis. The sudy includes patients from multiple hospitals and is based on retrospective review of medical records.

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Inclusion criteria

  • Age 0 to 17 years
  • Confirmed diagnosis of sickle cell disease (SS, SC, Sβ0, Sβ+)
  • Emergency department visit for painful vaso-occlusive crisis
  • Medical record available with complete documentation of pain management

Exclusion criteria

Exclusion Criteria:

  • Emergency department visit for a reason other than vaso-occlusive crisis
  • Pain not related to vaso-occlusive crisis
  • Incomplete medical record
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
92 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Time to first analgesic administration during vaso-occlusive crisis

    Time (in minutes) between emergency department admission and administration of the first analgesic for vaso-occlusive crisis, as documented in the medical record

    Time frame: During the index emergency department visit (up to 24 hours)

Secondary outcomes

  1. Type of analgesic treatment administered during vaso-occlusive crises

    Type of analgesic treatment administered for vaso-occlusive crisis (World Health Organization (WHO) pain ladder levels I,II,III, and combinations), as documented in the medical record.

    Time frame: During the index emergency department visit (up to 24 hours)

07

Study locations

3 sites
  • CHU de Reims - American Memorial Hospital
    Reims, Grand Est 51090, France
  • Hôpitaux Universitaires de Strasbourg - Hôpital de Hautepierre
    Strasbourg, Grand Est 67000, France
  • CHRU de Nancy - Hôpital d'enfants - Urgences pédiatriques
    Vandœuvre-lès-Nancy, Grand Est 54500, France
08

Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Nov 9, 2026
Show all 1 update
  1. Nov 9, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

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Registry details

Key details

Study ID
NCT07925372
Responsible party
Sponsor
First posted
Nov 9, 2026
Start date
Jun 1, 2026
Primary completion
Sep 30, 2026
Completion
Sep 30, 2026
Last update
Nov 9, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.

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