ClinicalTrials.gg
CompletedNCT07921693DPMPGUpdated Nov 6, 2026

The Impact of Dietary Phosphorus on Postprandial Metabolic Responses and Markers of Metabolic Health

An interventional study of high carbohydrate meal with phosphorus supplementation and Full fat milk meal with phosphate binder in Healthy Subjects (HS), Non Diabetic Patients and Normal Body Weight, sponsored by American University of Beirut Medical Center. Completed at 1 site in Lebanon. Open to participants aged 18 Years to 64 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-06.

Sponsored by American University of Beirut Medical Center · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Registered 3 years 7 months after the study started (first participant enrolled Feb 2023, registered Sep 2026).
Updated Nov 6, 2026Newly registeredGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
32
Allocation
Randomized
Ages
18 Years to 64 Years
Sex
All
01

Study summary

To examine the effects of dietary phosphorus availability, including supplementation and restriction conditions, on postprandial glucose responses in healthy adults.

Read the detailed description

Two randomized, controlled, crossover experiments were conducted in healthy adults. Experiment 1 evaluated a refined carbohydrate test meal with phosphorus supplementation (\~684 mg potassium phosphate) versus placebo. Experiment 2 assessed a dairy-based test meal under normal phosphorus availability versus reduced bioavailability using the phosphate-binding agent sevelamer carbonate. Each experiment followed a 10-day protocol comprising two intervention phases separated by a washout period. Within each phase, participants completed two identical test days per condition. Postprandial glucose was continuously monitored for 180 minutes. Primary outcomes included peak glucose, incremental glucose response (ΔBG), and incremental area under the curve (iAUC). Secondary outcomes included subjective appetite ratings assessed using validated visual analogue scale (VAS) questionnaires

02

Conditions studied

  • Healthy Subjects (HS)
  • Non Diabetic Patients
  • Normal Body Weight

Keywords

  • phosphorus
  • phosphate binder
  • postprandial glucose
  • appetite score
03

In context

Lead sponsor

American University of Beirut Medical Center is the lead sponsor of 158 studies on the registry; 24 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 64 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Non diabetic

Exclusion criteria

Exclusion Criteria:

  • pregnancy or lactation
  • diagnosis of diabetes
  • recent weight loss (>3% within 3 months); psychiatric illness
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single (Participant)
Enrollment
32 participants (actual)

Study arms

  • Sham comparator
    refined low phosphorus carbohydrate meal

    High-carbohydrate meal with low phosphorus content

    Dietary Supplement: high carbohydrate meal with phosphorus supplementation

  • Active comparator
    Full fat powdered milk meal

    The meal or drink was composed of full-fat powdered milk meal which is naturally high in phosphorus

    Drug: Full fat milk meal with phosphate binder

Interventions

  • Dietary supplementhigh carbohydrate meal with phosphorus supplementation

    high-carbohydrate meal with 684 mg of phosphorus supplement

  • DrugFull fat milk meal with phosphate binder

    Full fat dairy milk meal with 800 mg sevelamer carbonate (Renvela®)

06

What researchers measure

Primary outcomes

  1. postprandial glucose

    Monitoring glucose concentration

    Time frame: 10 days

Secondary outcomes

  1. Subjective appetite score

    changes in appetite scores between 0 -10 points

    Time frame: 180 minutes

07

Study locations

1 site
  • American University of Beirut
    Beirut, Lebanon
08

References and documents

Publications

  • Hammoud RU, Jabbour MN, Tawil AN, Ghattas H, Obeid OA. Phosphorus Supplementation Mitigated Food Intake and Growth of Rats Fed a Low-Protein Diet. Curr Dev Nutr. 2017 Jul 27;1(8):e000943. doi: 10.3945/cdn.117.000943. eCollection 2017 Aug. PubMed 29955716 ↗
  • Ragi ME, El Mallah C, Toufeili I, Obeid O. Concomitant lysine and phosphorus addition to a wheat gluten protein diet highly amplified growth measures of rats. Nutrition. 2019 Jul-Aug;63-64:69-74. doi: 10.1016/j.nut.2018.11.009. Epub 2018 Nov 30. PubMed 30933728 ↗
  • El Khoury R, El Solh N, Olabi A, Toufeili I, Hlais S, Obeid O. Macromineral enrichment of white bread reduces postprandial glycaemia without altering sensory properties: a crossover study. East Mediterr Health J. 2020 Nov 11;26(11):1388-1395. doi: 10.26719/2020.26.11.1388. PubMed 33226107 ↗

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

Individual participant data

Plan to share: No

09

Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Nov 6, 2026
Show all 1 update
  1. Nov 6, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07921693
Responsible party
Omar Obeid (professor, American University of Beirut Medical Center) — Principal investigator
First posted
Nov 6, 2026
Start date
Feb 17, 2023
Primary completion
Oct 1, 2025
Completion
Apr 1, 2026
Last update
Nov 6, 2026

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion