An observational study in Pulmonary Embolism (Diagnosis), sponsored by Antalya Health Sciences University. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-29.
Sponsored by Antalya Health Sciences University · Observational
This study will review the medical records of adults evaluated for a suspected blood clot in the lungs (pulmonary embolism) in the emergency department at Antalya Training and Research Hospital. It will include patients who underwent a lung perfusion scan, which shows blood flow in the lungs. Some patients also underwent a ventilation scan, which shows airflow in the lungs.
The main aim is to assess how scan findings were related to clinical decisions, including starting or stopping blood-thinning treatment, requesting additional imaging, and admitting patients to hospital or discharging them. The study will also examine time spent in the emergency department and hospital, intensive care admission, return visits to the emergency department, and deaths within 30 days.
Researchers will compare patients who had a perfusion scan alone with those who also had a ventilation scan. All tests and treatments were provided as part of routine care. The study will use existing records only; patients will not undergo additional tests, receive study treatments, or be contacted for research.
This single-center, retrospective observational cohort study will use routinely collected electronic health records from Antalya Training and Research Hospital. The historical review period begins on January 1, 2019, and extends to the ethics committee approval date. All eligible records within this period will be screened without random sampling.
Data sources will include emergency department records, nuclear medicine reports, laboratory results, radiology reports, and discharge summaries. Extracted variables will include presenting symptoms, comorbidities, risk factors for venous thromboembolism, vital signs, renal function, pregnancy status, contrast allergy, and available laboratory and imaging findings.
In routine practice at the study center, pulmonary perfusion scintigraphy is performed first. Ventilation scintigraphy is added when the perfusion findings require further clarification or when considered necessary by the nuclear medicine team. Imaging selection is determined by clinical care rather than the research protocol. Scan findings will be classified according to the original nuclear medicine reports as normal or low probability, high probability or suggestive of pulmonary embolism, or intermediate probability or nondiagnostic.
Clinical management before and after the scan report will be reviewed where documented. Management changes will be assessed using recorded diagnostic assessments, anticoagulation decisions, requests for additional imaging, and disposition decisions. A decision occurring after scintigraphy will not, by timing alone, be considered evidence that the scan changed management; attribution will depend on the available clinical documentation. Subsequent outcomes will be ascertained from existing records without additional patient contact.
Duplicate records from the same clinical episode will be excluded. Missing information and the availability of follow-up records will be documented. Absence of a recorded return visit or death will be distinguished from confirmed absence of the event.
Analyses will describe patient characteristics, scan findings, management decisions, and outcomes. Comparisons will be performed by imaging pathway and scan-result category using appropriate methods for categorical and continuous variables. Regression analyses may be used to examine associations with management changes and clinical outcomes, depending on the available sample size and number of events. Comparisons between imaging pathways will be interpreted with consideration of differences in clinical indications and baseline characteristics.
Data will be de-identified before analysis. No additional imaging, treatment, laboratory testing, or biological sample collection will be performed for research purposes.
756 studies on the registry are indexed under Pulmonary Embolism; 159 are open to participants now.
This study's planned enrollment of 100 is below the median of 361 across 332 observational studies indexed under Pulmonary Embolism.
Browse Pulmonary Embolism studies →Antalya Health Sciences University is the lead sponsor of 18 studies on the registry; 10 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adults aged 18 years or older who presented to the emergency department of Antalya Training and Research Hospital with suspected pulmonary embolism and underwent pulmonary perfusion scintigraphy, with or without additional ventilation scintigraphy, between January 1, 2019, and September 4, 2026. All eligible patients within this period will be identified retrospectively from hospital records. Approximately 100 patients are expected to be included.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Adults evaluated for suspected pulmonary embolism in the emergency department who underwent pulmonary perfusion scintigraphy without additional ventilation scintigraphy during routine clinical care. Clinical characteristics, imaging findings, management decisions, and patient outcomes will be assessed retrospectively from existing medical records.
Diagnostic Test: Pulmonary Perfusion Scintigraphy
Adults evaluated for suspected pulmonary embolism in the emergency department who underwent pulmonary perfusion scintigraphy followed by additional ventilation scintigraphy during routine clinical care. Clinical characteristics, imaging findings, management decisions, and patient outcomes will be assessed retrospectively from existing medical records.
Diagnostic Test: Pulmonary Perfusion Scintigraphy
Pulmonary perfusion scintigraphy performed during routine clinical care to evaluate suspected pulmonary embolism. Findings will be extracted retrospectively from existing nuclear medicine reports. No additional imaging will be performed for research purposes.
Proportion of Patients With a Documented Clinical Management Change Related to Scintigraphy Findings
Percentage of patients with at least one documented change related to scintigraphy findings in the diagnostic assessment of pulmonary embolism, initiation or discontinuation of anticoagulation, requests for additional imaging, or admission or discharge plans. Changes will be identified by retrospectively comparing documented assessments and plans before and after the scintigraphy report. A decision occurring after scintigraphy without evidence of a change in the documented plan will not be classified as a management change.
Time frame: Within 24 hours after the scintigraphy report becomes available.
Plan to share: Undecided — Individual participant data will not be shared because the dataset contains potentially sensitive clinical information obtained retrospectively from hospital records. Only aggregate results will be reported to protect patient privacy and confidentiality.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Antalya Health Sciences University