A Phase 1/2 interventional study of Povidone-Iodine in Dental Implant, sponsored by Madigan Army Medical Center. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years to 55 Years. Per ClinicalTrials.gov, last updated 2026-10-28.
Sponsored by Madigan Army Medical Center · Phase 1/2, Interventional, and Prevention
We hope to learn if applying antiseptic to the inside of a dental implant will decrease or alter the types of bacteria inside it which may then decrease the incidence of implant failure associated with bone loss, infection, and other complications. During your implant placement appointment, an antiseptic (povidone iodine) will be applied to the inside one of your two new dental implants, no antiseptic will be applied to your other dental implant (this is what would occur if you choose not to participate in this study), before covering both of them with a cover screw or healing abutment. You will return to the Madigan Oral \& Maxillofacial Surgery Clinic 3-6 months later when your implant hardware is removed a swab of the implants internal cavities will be collected. Your participation in this research will last up to 6 months and require one additional minute during both your implant placement and hardware removal appointments.
Madigan Army Medical Center is the lead sponsor of 26 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
The internal cavity of one dental implant will have a small volume of povidone iodine added to it before closure. The other dental implant will remain untreated.
Drug: Povidone-Iodine
All participants will receive this intervention in one implant and no intervention in a second implant.
Microbiome Diversity
Inverse Simpson index calculated following 16S microbiome sequencing
Time frame: From enrollment to hardware removal 3-6 months later
Implant Success Rate
Time frame: From enrollment to hardware removal 3-6 months later
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: Yes — Data may be shared if the appropriate regulatory approvals and agreements are in place.
Supporting information: Study protocol, Informed consent form
Time frame: For at least 3 years following manuscript publication
Access criteria: Investigators wishing to access the data should reach out to the study team. Data may be shared if the appropriate regulatory approvals and agreements are in place.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Madigan Army Medical Center