An interventional study of Acupuncture and Sham Acupuncture in Superoxide Dismutase and Acupuncture, sponsored by Universitas Indonesia. Not yet recruiting at 1 site in Indonesia. Open to participants aged 21 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-26.
Sponsored by Universitas Indonesia · Not applicable, Interventional, and Basic science
The goal of this randomized, double-blind clinical trial is to evaluate the effects of a single session of manual acupuncture on superoxide dismutase (SOD) enzyme activity and smoking cravings in active smokers aged 21-40 years. The study will also examine the correlation between changes in SOD enzyme activity and changes in smoking cravings, as measured by the Questionnaire of Smoking Urges-Brief (QSU-Brief).
The main questions it aims to answer are:
Researchers will compare a manual acupuncture group with a sham acupuncture group to determine whether manual acupuncture produces greater changes in SOD enzyme activity and smoking cravings.
Participants will:
Universitas Indonesia is the lead sponsor of 29 studies on the registry; 12 are open to participants now.
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Exclusion Criteria:
Participants will receive a single 30-minute session of manual acupuncture
Procedure: Acupuncture
Participants will receive a single 30-minute session of non-penetrating sham manual acupuncture
Procedure: Sham Acupuncture
Participants will receive a single 30-minute session of manual acupuncture at GV20 and bilateral ST36, SP6, and HT7 using sterile acupuncture needles (0.25 × 25 mm) with the Park Sham Needle Device.
Participants will receive a single 30-minute session of sham acupuncture at GV20 and bilateral ST36, SP6, and HT7 using the Park Sham Needle Device. Blunt, non-penetrating needles will be positioned at the same acupoints as the manual acupuncture group without penetrating the skin.
Change in Superoxide Dismutase (SOD) Enzyme Activity
Superoxide dismutase (SOD) enzyme activity will be measured from venous blood samples collected before and 90 minutes after the intervention using an enzyme-linked immunosorbent assay (ELISA). SOD activity will be expressed in U/gHb (units per gram of hemoglobin). Changes in SOD activity from baseline will be compared between the manual acupuncture and sham acupuncture groups.
Time frame: Baseline (before intervention) and 90 minutes after completion of the intervention.
Change in Questionnaire of Smoking Urges-Brief (QSU-Brief) Score
Smoking cravings will be assessed using the Questionnaire of Smoking Urges-Brief (QSU-Brief), a 10-item questionnaire rated on a 7-point Likert scale. Total scores range from 10 to 70, with higher scores indicating greater smoking cravings. The questionnaire will be completed before and immediately after the intervention. Changes in QSU-Brief scores from baseline will be compared between the manual acupuncture and sham acupuncture groups.
Time frame: Baseline (before intervention) and immediately after completion of the 30-minute intervention.
Plan to share: No — There is no plan to share individual participant data (IPD) with other researchers. Study findings will be reported in aggregate form without disclosing participants' identities.
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Universitas Indonesia