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Not yet recruitingNCT07890207HLC-CogMarkUpdated Oct 22, 2026

Human-LLM Conversations as a Digital Signature of Cognitive Performance in Adults

An observational study in Dementia, sponsored by Technion, Israel Institute of Technology. Not yet recruiting. Open to participants aged 60 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-22.

Sponsored by Technion, Israel Institute of Technology · Observational

Updated Oct 22, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Case-only
Time perspective
Cross-sectional
Enrollment
100
Ages
60 Years and older
Sex
All
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Study summary

Subtle changes in language are among the early signs of cognitive decline in Alzheimer's disease and related conditions. Researchers are therefore studying whether language can help identify cognitive changes earlier and at larger scale. Conversational AI tools (large language models, or LLMs) such as ChatGPT, Gemini, and Claude are now widely used, including by middle-aged and older adults. A conversation with an AI chatbot is more than a sample of written language: it shows how a person works toward a goal over several exchanges. This includes how they phrase requests, add constraints, keep track of context, notice errors, and revise their instructions. These behaviors may reflect language, attention, working memory, planning, and other aspects of cognitive function.

This exploratory, observational study will examine whether features of people's conversations with AI chatbots are associated with performance on a standard cognitive screening test. The study does not involve any treatment or intervention and is not intended to diagnose Alzheimer's disease, mild cognitive impairment, dementia, or any other condition.

Participants: 100 adults aged 60 and above who use AI chatbots and are proficient in English. Participants are recruited online through research crowdsourcing platforms (Prolific and DataForce). They do not need to have, or report, any diagnosis. No participants are recruited through clinics or hospitals.

Procedure: Participants complete a single online session of about 20 to 30 minutes. After giving informed consent, they:

Complete a background questionnaire covering demographics, language background, and AI chatbot use. Optional questions cover relevant medical and family history.

Upload three to five of their own previous conversations with an AI chatbot. They are asked to remove names and other identifying details first and to avoid highly sensitive conversations. They then answer a few short questions about each conversation.

Complete two short everyday tasks with a chatbot in the study interface: planning an activity and drafting a short message. The timing of typing and messages within the study interface is recorded.

Complete a remote MoCA test (XpressO), a validated self-administered digital cognitive screening tool, and the PHQ-8, a brief questionnaire on depressive symptoms.

A subset of participants may be invited to an optional additional assessment: the standard Montreal Cognitive Assessment (MoCA), administered by a trained examiner over video call. This is used to check how well the online test agrees with standard administration, and requires separate consent.

Outcomes: The primary outcome is the association between linguistic and interactional features of participants' AI conversations and their cognitive screening score, analyzed mainly as a continuous measure. Features include how specific and well structured requests are, how context is maintained, repetition, clarification, error recognition, revision strategies, progress through multi-step tasks, and typing and timing patterns. Secondary aims are to describe how adults aged 60 and over use AI chatbots, and to assess whether these features could support future computational methods for studying early cognitive change. Demographic, language, health, mood, and technology-use variables are considered as possible confounders.

Risks and safeguards: The study is minimal risk. The main risk is to privacy, because past chatbot conversations may contain personal information. Participants choose which conversations to share and are asked to remove identifying details. The research team removes any remaining direct identifiers, and data are stored on secure, access-restricted university servers. Data are analyzed by the academic research team and its research partner for research purposes only. Participants may feel mild fatigue or frustration; they can skip questions, take breaks, or stop at any time, and receive proportional compensation if they stop early. Individual scores are not reported. Participants whose screening score falls in the range that may indicate impairment receive a non-diagnostic note that explains the limits of screening tests and suggests discussing any memory concerns with a physician.

02

Conditions studied

  • Dementia

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Keywords

  • Dementia
  • AI
  • LLM
  • NLP
  • GPT
  • Large language models
03

In context

Dementia

2,231 studies on the registry are indexed under Dementia; 549 are open to participants now.

This study's planned enrollment of 100 is below the median of 250 across 500 observational studies indexed under Dementia.

Browse Dementia studies →

Lead sponsor

Technion, Israel Institute of Technology is the lead sponsor of 12 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
60 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Adults over the age of 60, proficient in English, regular (daily) use of AI-based chatbots. All levels of cognitive performance.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

Adults over the age of 60, proficient in English, regular (daily) use of AI-based chatbots.

Exclusion criteria

Exclusion Criteria:

All else.

05

Study design

Observational model
Case-only
Time perspective
Cross-sectional
Enrollment
100 participants (estimated)
Patient registry
No

Groups and cohorts

  • All participants

    Adults over the age of 60, proficient in English, who regularly use LLMs like GPT.

    Other: No Intervention: Observational Cohort

Interventions

  • OtherNo Intervention: Observational Cohort

    No intervention. Collecting cohort and analyzing data.

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What researchers measure

Primary outcomes

  1. Association between features of human-AI chatbot conversations and cognitive screening score

    The study measures linguistic and interactional features from participants' uploaded AI chatbot conversations and from two standardized chatbot tasks. Examples include request specificity and structure, context maintenance, repetition, clarification, error recognition, revision strategies, task progression, and typing and timing patterns. The association between these features and the MoCA XpressO total score is analyzed, with the score treated as a continuous measure.

    Time frame: Day 1 (single online session at enrollment, about 20-30 minutes)

Secondary outcomes

  1. Patterns of AI chatbot use

    Descriptive summary of self-reported AI chatbot use: platforms used, duration and frequency of use, main purposes, language of use, and whether others help with use. Collected by questionnaire.

    Time frame: Day 1 (single online session at enrollment)

  2. Performance of conversation features in estimating cognitive screening score

    How well computational models based on conversation features estimate the MoCA XpressO score, assessed with cross-validation. Reported as correlation with the observed score and as the area under the ROC curve for classifying scores above versus below the validated cutoff.

    Time frame: Day 1 (single online session at enrollment)

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Study locations

No study locations are listed for this record.

08

Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Oct 22, 2026
Show all 1 update
  1. Oct 22, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

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Registry details

Key details

Study ID
NCT07890207
Lead sponsor
Technion, Israel Institute of Technology
Responsible party
Lotem Peled-Cohen (Lotem Peled-Cohen, Technion, Israel Institute of Technology) — Principal investigator
First posted
Oct 22, 2026
Start date
Dec 1, 2026 (estimated)
Primary completion
Mar 30, 2027 (estimated)
Completion
Jun 30, 2027 (estimated)
Last update
Oct 22, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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