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Not yet recruitingNCT07883096PSKUpdated Oct 20, 2026

Parsing the Impact of Calories Versus Sweet Taste on Beverage Brand Conditioning

An interventional study of 3-week daily beverage intervention in Neuropsychology and Ingestive Behavior, sponsored by Monell Chemical Senses Center. Not yet recruiting. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-20.

Sponsored by Monell Chemical Senses Center · Not applicable, Interventional, and Basic science

Updated Oct 20, 2026Newly registeredGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
176
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
All
01

Study summary

The purpose of this study is to learn how the sweet taste and the calorie content of a beverage affect the way people respond to the brand logo printed on that beverage. Previous work suggests that once a logo has been paired repeatedly with a rewarding drink, the logo alone can capture attention and increase the desire to consume. What is not yet known is whether the sweet taste, the calories, or both are responsible. Two current scientific explanations disagree on this point, and the study is designed to compare them. The investigators plan to enroll 176 healthy adults, 18 to 45 years old, with a body mass index between 18 and 34. People will not be eligible if they cannot safely have an MRI scan, are actively trying to lose weight or taking weight-loss medication, have a history of a taste, smell, or eating disorder, or have an active neurological condition.

02

Conditions studied

  • Neuropsychology
  • Ingestive Behavior

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Keywords

  • sugar-sweetened beverage
  • fMRI
  • non-nutritive sweetener
  • neuropsychology
  • ingestive behavior
03

In context

Feeding Behavior

243 studies on the registry are indexed under Feeding Behavior; 101 are open to participants now.

This study's planned enrollment of 176 is above the median of 80 across 181 interventional studies indexed under Feeding Behavior.

Browse Feeding Behavior studies →

Lead sponsor

Monell Chemical Senses Center is the lead sponsor of 18 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Adults 18-45 years old
  2. BMI = 18-34 kg/m2
  3. Speak English fluently

Exclusion criteria

Exclusion Criteria:

  • Current or past diagnosis of diabetes or metabolic disorder (thyroid disease, etc.)
  • Current or intended weight loss efforts (behavioral, GLP-1 agonists)
  • Gastric bypass or GLP-1 use in the previous 6 months
  • Current pregnancy or planning to become pregnant in the next 6 weeks
  • Claustrophobia (this would make lying in an MRI scanner very uncomfortable).
  • History of head injury resulting in loss of consciousness for more than 10 minutes
  • Contraindications to MRI: Individuals with a pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel workers, or other implants.
  • History of diagnosed taste, smell, or eating disorders
  • History of alcohol or drug dependence
  • Active neurologic disorder
  • Food allergies or restrictive diet
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
176 participants (estimated)

Study arms

  • Experimental
    Sugar-sweetened beverage

    Dietary Supplement: 3-week daily beverage intervention

  • Experimental
    Nonnutritive Sweetener

    Dietary Supplement: 3-week daily beverage intervention

  • Experimental
    High-fructose corn syrup

    Dietary Supplement: 3-week daily beverage intervention

  • No intervention
    Control

Interventions

  • Dietary supplement3-week daily beverage intervention

    Beverage/brand condition with either sugar-sweetened beverage, nonnutritive sweetener, high-fructose corn syrup, or control.

06

What researchers measure

Primary outcomes

  1. Stop Signal Task

    Time frame: Completed during the pre- and post-intervention assessment visits scheduled at baseline and within 1-2 weeks of the 3-week long intervention.

  2. Body Composition

    Body Fat Mass, Lean Body Mass, Skeletal Muscle Mass, Total Body Water, all measured in kg

    Time frame: Completed during the pre- and post-intervention assessment visits scheduled at baseline and within 1-2 weeks of the 3-week long intervention.

Secondary outcomes

  1. Questionnaire

    Dutch Eating Questionnaire

    Time frame: Completed during the pre- and post-intervention assessment visits scheduled at baseline and within 1-2 weeks of the 3-week long intervention.

  2. Questionnaire

    Barratt Impulsiveness Scale

    Time frame: Completed during the pre- and post-intervention assessment visits scheduled at baseline and within 1-2 weeks of the 3-week long intervention.

  3. Questionnaire

    International Physical Activity Questionnaire

    Time frame: Completed during the pre- and post-intervention assessment visits scheduled at baseline and within 1-2 weeks of the 3-week long intervention.

  4. Questionnaire

    Power of Food Scale

    Time frame: Completed during the pre- and post-intervention assessment visits scheduled at baseline and within 1-2 weeks of the 3-week long intervention.

  5. Questionnaire

    Pittsburgh Sleep Quality Index

    Time frame: Completed during the pre- and post-intervention assessment visits scheduled at baseline and within 1-2 weeks of the 3-week long intervention.

07

Study locations

No study locations are listed for this record.

08

Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Oct 20, 2026
Show all 1 update
  1. Oct 20, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

09

Registry details

Key details

Study ID
NCT07883096
Lead sponsor
Monell Chemical Senses Center
Responsible party
Sponsor
First posted
Oct 20, 2026
Start date
Mar 2027 (estimated)
Primary completion
Aug 2030 (estimated)
Completion
May 2031 (estimated)
Last update
Oct 20, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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