An observational study in Endometriosis, Postoperative Pain and Pain Trajectories, sponsored by Centre Hospitalier Universitaire, Amiens. Recruiting at 1 site in France. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-20.
Sponsored by Centre Hospitalier Universitaire, Amiens · Observational
The pain associated with endometriosis reflects a multifactorial pathophysiology combining peripheral nociception, central sensitisation and psychosocial factors. Although surgery is an integral part of treatment, a significant proportion of patients experience persistent pain several months after the procedure. To date, postoperative pain trajectories after endometriosis surgery remain poorly characterised, and there are no reliable predictors of chronic postoperative pain (CPP). This prospective, single-centre, longitudinal study aims to identify distinct postoperative pain trajectories and to assess whether perioperative quantitative sensory testing can predict the development of chronic postoperative pain at 3 and 6 months. Patients will undergo perioperative mechanical and pressure tests, including assessment of temporal summation and pressure pain thresholds, combined with validated measures of patient- reported outcomes. Follow-up assessments will be conducted on day 2, day 14, 1 month, 3 months, and 6 months after surgery to capture the dynamic evolution of pain, quality of life, fatigue, sexual function, and central sensitisation symptoms.
925 studies on the registry are indexed under Endometriosis; 264 are open to participants now.
This study's planned enrollment of 150 is above the median of 125 across 354 observational studies indexed under Endometriosis.
Browse Endometriosis studies →Centre Hospitalier Universitaire, Amiens is the lead sponsor of 582 studies on the registry; 181 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients operated for endometriosis in CHRU Amiens
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Perioperative quantitative sensory testing (mechanical temporal summation and pressure pain thresholds)
Repeated administration of validated patient-reported outcome questionnaires
Brief Pain Inventory values for pain intensity and interference measurement
Postoperative pain trajectories derived from repeated assessments of pain intensity and interference (Brief Pain Inventory) Brief Pain Inventory (BPI) is a questionnaire with 15 questions. For each question 0 is the smallest score and 10 is the highest score
Time frame: day 2
EHP-5 values for quality of life measurement
Postoperative pain trajectories derived from quality of life (EHP-5) EHP-5 (Endometriosis health profile 5) is a questionnaire with 10 questions
Time frame: day 2
EHP-5 values for quality of life measurement
Postoperative pain trajectories derived from quality of life (EHP-5) EHP-5 (Endometriosis health profile 5) is a questionnaire with 10 questions
Time frame: at 6 months
FSFI values for sexual function measurement
Postoperative pain trajectories derived sexual function (FSFI), Female Sexual Function Index (FSFI) is a questionnaire with 4 questions
Time frame: day 2
FSFI values for sexual function measurement
Postoperative pain trajectories derived sexual function (FSFI), Female Sexual Function Index (FSFI) is a questionnaire with 4 questions
Time frame: at 6 months
Brief Pain Inventory values for pain intensity and interference measurements
Postoperative pain trajectories derived from repeated assessments of pain intensity and interference (Brief Pain Inventory)
Time frame: at 6 months
PROMIS Fatigue SF-6a values for fatigue measurement
Postoperative pain trajectories derived from fatigue (PROMIS Fatigue SF-6a) PROMIS Fatigue SF-6a is a questionnaire with 6 questions
Time frame: day 2
PROMIS Fatigue SF-6a values for fatigue measurement
Postoperative pain trajectories derived from fatigue (PROMIS Fatigue SF-6a) PROMIS Fatigue SF-6a is a questionnaire with 6 questions
Time frame: at 6 months
Convergences PP values for central sensitization symptoms measurement
Postoperative pain trajectories derived from and central sensitization symptoms (Convergences PP) Score Convergence PP is a questionnaire with 4 questions
Time frame: day 2
Convergences PP values for central sensitization symptoms measurement
Postoperative pain trajectories derived from and central sensitization symptoms (Convergences PP) Score Convergence PP is a questionnaire with 4 questions
Time frame: at 6 months
Prevalence of chronic postsurgical pain
Time frame: at 3 months
Prevalence of chronic postsurgical pain
Time frame: at 6 months
Correlation between pain trajectories and CPSP
Time frame: at 3 months
Predictive value of perioperative QST parameters
Predictive value of perioperative QST parameters (preoperative and postoperative day 2) for CPSP
Time frame: at 3 months
Predictive value of perioperative QST parameters
Predictive value of perioperative QST parameters (preoperative and postoperative day 2) for CPSP
Time frame: at 6 months
Plan to share: No
No publications or documents are linked to this record.
Started Jul 2026 (actual). Primary completion is estimated for Jul 2028, 24 months after the start.
Of 153 non-industry observational studies under Endometriosis, half reached primary completion within 30 months of starting (the median), counting those still running; a quarter within 14 and three quarters within 48. This study's planned 24 months is below that.
Counting every sponsor, half of 182 studies reached it within 30 months; a quarter within 14 and three quarters within 48.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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