An interventional study of 0.1% Ropivacaine in Labor Pain, sponsored by General Hospital of Ningxia Medical University. Not yet recruiting. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-10-20.
Sponsored by General Hospital of Ningxia Medical University · Not applicable, Interventional, and Treatment
This study aims to determine the 90% effective dose (ED₉₀) of an initial regimen of 0.1% ropivacaine combined with 0.3 μg/mL sufentanil, administered via the double dural puncture epidural technique for epidural labor analgesia.
Epidural labor analgesia is a widely adopted pain management modality for parturition. Recent technical advances including the dural puncture epidural (DPE) technique have considerably improved the quality of the childbirth experience. The double dural puncture epidural technique appears to improve this effect more effectively. This study aims to determine the 90% effective dose (ED₉₀) of an initial regimen of 0.1% ropivacaine + 0.3 μg/mL sufentanil, administered via the double dural puncture epidural technique for epidural labor analgesia.
409 studies on the registry are indexed under Labor Pain; 69 are open to participants now.
This study's planned enrollment of 30 is below the median of 100 across 336 interventional studies indexed under Labor Pain.
Browse Labor Pain studies →General Hospital of Ningxia Medical University is the lead sponsor of 106 studies on the registry; 40 are open to participants now.
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Labor analgesia via double dural puncture epidural technique
Drug: 0.1% Ropivacaine
An initial bolus of 0.1% ropivacaine + sufentanil 0.3 µg/mL, with a total volume of 10 mL (containing 10 mg ropivacaine), was administered to the first patient. For subsequent patients, the dose was adjusted in increments or decrements of 2 mL (2 mg 0.1% ropivacaine), based on whether a VAS score of less than 3 was achieved within 30 minutes after administration.
The ED₉₀ of ropivacaine
The ED₉₀ of ropivacaine required for parturients to achieve an numerical rating scale (NRS) pain score \<3 within 30 minutes following the initial administration.
Time frame: When the fetus is delivered
Numerical rating scale (NRS) pain score
0-10; 0 = no pain, 10 = unbearable pain
Time frame: 10, 20, and 30 minutes after initial administration.
Bromage score
0: full flexion of knees and ankles; 1: partial knee flexion with full ankle flexion; 2: inability to flex knees with partial ankle flexion; 3: inability to flex knees or ankles
Time frame: 30, 60, 120, 180, and 240 minutes after initial administration
APGAR score
A= Appearance P=Pulse G=Grimace A=Attitude R=Respiration
Time frame: 1 minute after delivery
APGAR score
A= Appearance P=Pulse G=Grimace A=Attitude R=Respiration
Time frame: 5 minutes after delivery
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Ropivacaine
General Hospital of Ningxia Medical University →