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CompletedNCT07881913Updated Oct 20, 2026

Comparison of Bracing and Eccentric Loading Exercises on Pain Modulation and Functional Improvement in Acute Pes Anserine Bursitis Patients

An interventional study of Medial-Support Knee Brace and Eccentric Loading Exercise in Pes Anserine Bursitis, sponsored by Dr Aneeqa Sultan. Completed at 2 sites in Pakistan. Open to participants aged 20 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-10-20.

Sponsored by Dr Aneeqa Sultan · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 11 months after the study started (first participant enrolled Oct 2025, registered Oct 2026).
Updated Oct 20, 2026Newly registeredGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
32
Allocation
Randomized
Ages
20 Years to 50 Years
Sex
All
01

Study summary

This study aims to compare the effects of knee bracing and eccentric loading exercises on pain and functional ability in adults with acute pes anserine bursitis. Pes anserine bursitis is a condition affecting the inner side of the knee that can cause pain and difficulty with activities such as walking, climbing stairs, and standing up from a chair.

A total of 32 participants will be included in the study and divided into two groups. One group will receive a knee-bracing intervention, while the other group will participate in a structured exercise program involving eccentric loading and strengthening exercises for the muscles around the knee.

The bracing group will be instructed to wear a properly fitted medial-support knee brace for approximately 6-8 hours daily during weight-bearing activities. The exercise group will perform prescribed exercises three times per week for eight weeks, with exercise intensity adjusted according to individual tolerance.

Pain intensity and knee-related functional ability will be assessed using the Visual Analogue Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Assessments will be conducted before treatment and at the planned follow-up visits to evaluate changes in symptoms and function.

The findings are intended to help determine which intervention provides greater improvement in pain and functional ability in people with acute pes anserine bursitis and may help guide physiotherapy treatment decisions.

Read the detailed description

Pes anserine bursitis is a condition involving irritation or inflammation of the bursa located near the insertion of the sartorius, gracilis, and semitendinosus tendons on the inner side of the knee. It may cause localized pain and tenderness and can limit daily activities, including walking, climbing stairs, standing up from a chair, and performing other movements involving the knee.

Conservative physiotherapy management may include exercise therapy and external support. Exercise therapy aims to improve the strength and functional capacity of the muscles surrounding the knee, while a knee brace may provide support during weight-bearing activities. However, further comparative evidence is needed to determine which approach provides greater improvements in pain and functional ability in patients with acute pes anserine bursitis.

**Study objective**

The objective of this randomized controlled trial is to compare the effects of knee bracing and eccentric loading exercises on pain intensity and knee-related functional ability in adults with acute pes anserine bursitis. The study is intended to determine whether either intervention provides greater improvement in the measured outcomes.

**Study design and treatment groups**

The study uses a two-group, parallel randomized controlled trial design. Eligible participants are assigned to one of two intervention groups following screening and informed consent. The planned sample comprises 32 participants, with 16 participants allocated to each group.

**Bracing group**

Participants assigned to the bracing group receive a properly fitted medial-support knee brace. The prescribed wearing schedule is approximately 6-8 hours daily during weight-bearing activities for eight weeks. Participants are instructed on the correct use and care of the brace.

**Eccentric loading exercise group**

Participants assigned to the exercise group follow a structured exercise program targeting the muscles surrounding the knee, including the quadriceps and hamstrings. The program includes strengthening and functional exercises, such as leg raises, hamstring curls, and step-ups. Exercises are prescribed three times per week for eight weeks, with three sets of approximately 10-15 repetitions, adjusted according to the participant's tolerance and ability. Exercise intensity progresses gradually as tolerated.

**Outcome assessment**

Pain intensity is assessed using the Visual Analogue Scale (VAS), and knee-related symptoms and functional limitations are assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). These instruments are used to evaluate changes in pain and function over the course of the intervention.

Baseline assessments are performed before treatment. Follow-up assessments are planned to evaluate treatment response and determine whether improvements are maintained. The final assessment schedule should correspond to the actual visits completed and the time points specified in the approved study protocol.

**Data analysis**

Participant characteristics are summarized using descriptive statistics. Within-group changes and between-group differences in pain and functional outcomes are evaluated using appropriate statistical methods. The choice of statistical tests depends on the distribution of the data, the study design, and the availability of measurements at each assessment time point.

Potential significance

The findings may contribute to the evidence supporting conservative physiotherapy management of acute pes anserine bursitis. Comparing these interventions may help physiotherapists make informed treatment decisions based on improvements in pain and knee-related function.

02

Conditions studied

  • Pes Anserine Bursitis

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Keywords

  • Pes Anserine Bursitis
  • Knee Pain
  • Knee Bracing
  • Eccentric Loading Exercises
  • Exercise Therapy
  • Physiotherapy
  • Visual Analogue Scale
  • Western Ontario and McMaster Universities Osteoarthritis Index
03

In context

Bursitis

417 studies on the registry are indexed under Bursitis; 112 are open to participants now.

This study's enrollment of 32 is below the median of 45 across 376 interventional studies indexed under Bursitis.

Browse Bursitis studies →

Lead sponsor

Dr Aneeqa Sultan is the lead sponsor of 2 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 50 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adults aged 20-50 years, both male and female.
  • Patients diagnosed with early-stage pes anserine bursitis based on clinical symptoms and imaging.
  • Body mass index (BMI) between 20 and 35.
  • Pain intensity score between 4 and 7.
  • Participants with or without previous surgeries.

Exclusion criteria

Exclusion Criteria:

  • Advanced arthritis or systemic inflammatory conditions, such as systemic lupus erythematosus (SLE).
  • Recent lower-limb fracture.
  • Pregnancy or other considerations that contraindicate physical therapy or bracing.
  • Neurological disorders affecting mobility, such as spinal cord injuries.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
32 participants (actual)

Study arms

  • Experimental
    Bracing Group

    Participants will use a medial-support knee brace daily for 6-8 hours during mobility for 8 weeks. The intervention aims to reduce pain and improve functional ability in patients with acute pes anserine bursitis.

    Device: Medial-Support Knee Brace

  • Experimental
    Eccentric Loading Exercise Group

    Participants will receive a structured exercise program targeting the quadriceps and hamstring muscles. Supervised sessions will be conducted three times per week for 8 weeks, with 3 sets of 10-15 repetitions. Exercises will progress from low to moderate intensity according to participant tolerance.

    Behavioral: Eccentric Loading Exercise

Interventions

  • DeviceMedial-Support Knee Brace

    Participants will use a medial-support knee brace daily for 6-8 hours during mobility for 8 weeks. The intervention will be used in patients with acute pes anserine bursitis to assess its effects on pain modulation and functional improvement.

  • BehavioralEccentric Loading Exercise

    Participants will perform a structured exercise program targeting the quadriceps and hamstring muscles for 8 weeks. Supervised sessions will be conducted three times per week, with 3 sets of 10-15 repetitions. Exercise intensity will progress according to participant tolerance.

06

What researchers measure

Primary outcomes

  1. Change in Pain Intensity Measured by the Visual Analogue Scale (VAS)

    Pain intensity will be assessed using the Visual Analogue Scale (VAS) before and after the intervention. Changes in VAS scores will be used to evaluate pain reduction following bracing or eccentric loading exercise in patients with acute pes anserine bursitis.

    Time frame: Baseline and after 8 weeks of intervention

Secondary outcomes

  1. Change in Knee Pain and Functional Ability Measured by the WOMAC Index

    Knee-related pain and functional ability will be assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) before and after the intervention. Changes in WOMAC scores will be used to evaluate improvement following bracing or eccentric loading exercise.

    Time frame: Baseline and after 8 weeks of intervention

07

Study locations

2 sites
  • Lahore Poly Clinic
    Lahore, Punjab Province, Pakistan
  • M. Ali clinic
    Lahore, Punjab Province, Pakistan
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Oct 20, 2026
Show all 1 update
  1. Oct 20, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07881913
Lead sponsor
Dr Aneeqa Sultan
Responsible party
Dr Aneeqa Sultan (Reserach Associate, Superior University) — Sponsor-investigator
First posted
Oct 20, 2026
Start date
Oct 20, 2025
Primary completion
Apr 27, 2026
Completion
Aug 27, 2026
Last update
Oct 20, 2026

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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