An interventional study of Individualized Pulsed Field Ablation Guided by Pulmonary Vein Antral Substrate Mapping in Atrial Fibrillation (AF), sponsored by Xi'an Jiaotong University. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-22.
Sponsored by Xi'an Jiaotong University · Not applicable, Interventional, and Treatment
This study will adopt a prospective, single-center, single-arm research design, enrolling 120 patients with paroxysmal or persistent atrial fibrillation who are scheduled to undergo catheter ablation for the first time. Individualized pulsed electrical field pulmonary vein isolation will be performed under the guidance of pulmonary vein vestibular stromal mapping. By recording the distribution characteristics of abnormal stroma in the pulmonary vein vestibule, the guidance situation of the ablation strategy based on the mapping results, surgical and ablation parameters, immediate pulmonary vein isolation effect, perioperative complications, and the 12-month recurrence-free survival rate of atrial arrhythmias after surgery, the feasibility, effectiveness and safety of this ablation strategy will be evaluated, and the relationship between the characteristics of pulmonary vein vestibular stroma and postoperative recurrence will be explored. This will provide more clinical experience and data support for individualized ablation under the guidance of pulmonary vein vestibular stromal mapping.
3,957 studies on the registry are indexed under Atrial Fibrillation; 933 are open to participants now.
This study's planned enrollment of 120 is below the median of 145 across 2,437 interventional studies indexed under Atrial Fibrillation.
Browse Atrial Fibrillation studies →Xi'an Jiaotong University is the lead sponsor of 32 studies on the registry; 8 are open to participants now.
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Procedure: Individualized Pulsed Field Ablation Guided by Pulmonary Vein Antral Substrate Mapping
Before ablation, electroanatomic voltage mapping of the left atrium and pulmonary vein antra will be performed. Low-voltage areas will be identified using prespecified thresholds according to the rhythm during mapping: \<0.5 mV during sinus rhythm and \<0.3 mV during atrial fibrillation. Mapping findings will guide an individualized pulmonary vein isolation strategy, including the ablation boundary and segmental lesion delivery, according to the study protocol. Pulsed field energy will be delivered using the PFA catheter and system specified in the protocol. Repeat mapping will be performed 20-30 minutes after ablation to assess the lesion set and identify residual conduction or reconnection.
Freedom From Atrial Tachyarrhythmia Recurrence
Time frame: From the end of the 3-month blanking period through 12 months after ablation
Acute Ablation Success Rate
Time frame: At the end of the ablation procedure, after a 20- to 30-minute waiting period
Atrial Tachyarrhythmia During the Blanking Period
Time frame: From ablation through 3 months after ablation
Procedure- or PFA-Related Adverse Events
Time frame: From the start of the ablation procedure through 12 months after ablation
No study locations are listed for this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Xi'an Jiaotong University