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CompletedNCT07879261SubstancesUpdated Oct 16, 2026

Hazardous Substances Injuries

An observational study in Occupational Diseases, sponsored by Sergio Gabriel Susmallian. Completed at 1 site in Israel. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-16.

Sponsored by Sergio Gabriel Susmallian · Observational

Updated Oct 16, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
1,951
Ages
18 Years and older
Sex
All
01

Study summary

This clinical study aims to evaluate the effectiveness and safety of [intervention or treatment] in patients with [clinical condition]. The study will investigate whether this intervention improves [primary clinical outcome] compared with [standard treatment or control group]. Participants will undergo clinical assessment and follow-up according to the study protocol. The findings may provide additional evidence regarding the clinical effectiveness, safety, and potential benefits of this treatment.

Read the detailed description

This study is designed to investigate the clinical effectiveness and safety of [intervention] in patients diagnosed with [clinical condition]. The primary objective is to evaluate the effect of the intervention on [primary outcome]. Secondary objectives include the assessment of [secondary outcomes], treatment-related complications, and other relevant clinical parameters.

Eligible participants will be enrolled according to predefined inclusion and exclusion criteria. Participants will receive [description of intervention], and clinical outcomes will be assessed using standardized evaluation methods at predetermined follow-up intervals.

Data will be collected prospectively and analyzed to assess the primary and secondary study outcomes. Safety assessments will include the documentation of adverse events and treatment-related complications.

02

Conditions studied

  • Occupational Diseases

Keywords

  • Hazardous substances
  • Contact Dermatitis
  • Toxic Effects of Chemical Substances
  • Disability burden
03

In context

Occupational Diseases

49 studies on the registry are indexed under Occupational Diseases; 12 are open to participants now.

This study's enrollment of 1,951 is above the median of 255 across 23 observational studies indexed under Occupational Diseases.

Browse Occupational Diseases studies →

Lead sponsor

Sergio Gabriel Susmallian is the lead sponsor of 5 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

The study population comprises individuals with occupational claims related to exposure to hazardous substances recorded in the National Insurance Institute of Israel administrative database between January 1, 2018, and December 31, 2025. The nationwide dataset includes information on demographic characteristics, geographic distribution, exposure-related diagnoses, medical assessments, temporary and permanent disability determinations, assigned disability severity, and compensation classifications. Solar and sunlight-related conditions are excluded from the diagnostic analysis. The study includes all eligible administrative records without additional participant recruitment or clinical interventions.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Individuals with occupational injury or disease claims related to exposure to hazardous chemical substances or other non-solar hazardous agents recorded in the National Insurance Institute of Israel database between January 1, 2018, and December 31, 2025.
  • Claims classified as occupational substance exposure according to the administrative diagnostic and exposure classification system.
  • Records containing information relevant to at least one study outcome, including demographic characteristics, clinical diagnoses, disability determinations, assigned disability percentages, or compensation classifications.
  • Both male and female claimants.
  • Workers 18 y.o. and higher

Exclusion criteria

Exclusion Criteria:

  • Claims exclusively related to solar radiation, sunlight exposure, or associated actinic conditions.
  • Occupational claims unrelated to hazardous substance exposure.
  • Records outside the study period.
  • Records without sufficient information to establish eligibility for the occupational substance-exposure cohort.
  • Duplicate administrative records representing the same determination, when identifiable. Separate legitimate claims or determinations relating to the same individual will not automatically be excluded.
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
1,951 participants (actual)
Patient registry
No

Groups and cohorts

  • Workers With Occupational Exposure to Hazardous Substances

    Workers with occupational claims related to exposure to hazardous chemical substances and other non-solar hazardous agents recorded in the National Insurance Institute of Israel database between January 2018 and December 2025. The study includes administrative information on demographic characteristics, occupational exposure-related diagnoses, geographic distribution, medical assessments, temporary and permanent disability determinations, assigned disability severity, and compensation classifications. Solar and sunlight-related conditions are excluded from the diagnostic analysis. All data were collected retrospectively from existing administrative records.

    Other: Retrospective Administrative Data Assessment

Interventions

  • OtherRetrospective Administrative Data Assessment

    Retrospective analysis of existing occupational insurance records to evaluate hazardous substance-exposure claims, associated clinical conditions, and disability outcomes. No treatment, experimental exposure, or clinical intervention is administered.

06

What researchers measure

Primary outcomes

  1. Occupational Hazardous Substance-Exposure Claim Rate

    Annual number of recognized occupational hazardous substance-exposure claims per 100,000 employed persons in Israel. Rates will be calculated using annual claim counts and the average national employed population. Temporal trends will be evaluated across the study period using regression models with appropriate denominator offsets. The outcome is an administrative claim rate rather than the incidence of occupational disease or exposure.

    Time frame: January 1, 2018, through December 31, 2025

07

Study locations

1 site
  • Israel National Insurance Institute
    Jerusalem, 91099, Israel
08

References and documents

Publications

  • Jacobsen G, Rasmussen K, Bregnhoj A, Isaksson M, Diepgen TL, Carstensen O. Causes of irritant contact dermatitis after occupational skin exposure: a systematic review. Int Arch Occup Environ Health. 2022 Jan;95(1):35-65. doi: 10.1007/s00420-021-01781-0. Epub 2021 Oct 19. PubMed 34665298 ↗
  • Schutte MG, Tamminga SJ, de Groene GJ, Kezic S, van der Molen HF. Work-related and personal risk factors for occupational contact dermatitis: A systematic review of the literature with meta-analysis. Contact Dermatitis. 2023 Mar;88(3):171-187. doi: 10.1111/cod.14253. Epub 2022 Dec 12. PubMed 36444496 ↗
  • Feveile H, Christensen KB, Flyvholm MA. Self-reported occupational skin contact with cleaning agents and the risk of disability pension. Contact Dermatitis. 2009 Mar;60(3):131-5. doi: 10.1111/j.1600-0536.2008.01495.x. PubMed 19260909 ↗

Individual participant data

Plan to share: No — Individual participant data will not be publicly shared because the study uses confidential administrative records obtained from the National Insurance Institute of Israel. Access to individual-level data is restricted by applicable privacy regulations, institutional policies, and data-use agreements. De-identified aggregate results, statistical summaries, and methodological information may be made available in scientific publications or upon reasonable request, subject to institutional approval.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jan 2018 to primary completion in Dec 2025, 95 months.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 10, 2026
First posted
Oct 16, 2026
StartActual
Jan 1, 2018
Primary completionActual
Dec 31, 2025
CompletionActual
Dec 31, 2025
Last update
Oct 16, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Registered
First appeared on the registry. No changes since
Oct 16, 2026
Show all 1 update
  1. Oct 16, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07879261
Lead sponsor
Sergio Gabriel Susmallian
Collaborators
Assuta Medical Center
Responsible party
Sergio Gabriel Susmallian (Medicine doctor, Assuta Medical Center) — Sponsor-investigator
First posted
Oct 16, 2026
Start date
Jan 1, 2018
Primary completion
Dec 31, 2025
Completion
Dec 31, 2025
Last update
Oct 16, 2026

Study contacts

Yoram Chaiter
study director · National Insurance Institute of Israel

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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