An observational study in Addiction, sponsored by University of Bordeaux. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-16.
Sponsored by University of Bordeaux · Observational
Addiction is a psychiatric disorder associated with craving, an unwanted, intense and persistent desire to use the substance/addictive behavior, leading to frequent relapses. Craving is fluctuating, influenced by internal factors or environmental context, and can be evaluated only by self-report which can be burdensome. It has been shown that craving predicts relapse, making it a major treatment target in addiction. Identify biomarkers of craving could enable to detect craving in a passive way (without major effort from individuals to report it) and would be a major improvement. The goal of this observational study is to explore if voice could be a biomarker of craving in adults with substance or behavioral addictions. The main question it aims to answer is:
521 studies on the registry are indexed under Behavior, Addictive; 124 are open to participants now.
This study's planned enrollment of 120 is below the median of 158 across 106 observational studies indexed under Behavior, Addictive.
Browse Behavior, Addictive studies →University of Bordeaux is the lead sponsor of 17 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Participants will be recruited from outpatient addiction treatment centers and the general population through social media, university and research websites, posters, and broader communication campaigns in the Bordeaux metropolitan area.
Inclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Adults meeting Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) criteria for diagnosis for a substance use disorder (SUD) /behavioral addiction, recruited to complete voice recordings during cue-reactivity protocol and during 14-28 days Ecological Momentary Assessment (EMA) protocol.
Other: Cue reactivity paradigm · Other: Ecological momentary assessment
Single laboratory session during which participants undergo a cue-reactivity protocol and are exposed to neutral, addiction-cue, and stress-inducing conditions. Participants realize three different speech tasks (text reading, image description, response to semi-spontaneous question) recorded before and after the visualization of images, either neutral, addiction- related or stress-related. Craving and stress level are collected at different time during each block. No active treatment or intervention is administered.
Repeated ambulatory assessments: short smartphone questionnaires 4 times per day for 14-28 days to report craving, substance use/addictive behavior, and daily experiences, and self-initiated event-contingent reports of craving or substance use/addictive behavior. Some of the questionnaires have vocal items that should be directly answered by the participant speaking out loud. No intervention is provided.
Vocal acoustic features during the laboratory cue-reactivity protocol
Comparison of acoustic parameters across conditions (neutral, addiction, versus stress conditions): fundamental frequency, pitch, formants, speech rate, articulation rate will be extracted from voice recordings collected during standardized text reading, image description, and semi-spontaneous speech tasks, using custom Python scripts.
Time frame: Day 1 of individual participant timeline
Vocal acoustic features during daily life
Comparison of acoustic parameters in craving versus no-craving assessments: fundamental frequency, pitch, formants, speech rate, articulation rate will be extracted from voice recordings collected during semi-spontaneous speech elicited during EMA questionnaires, using custom Python scripts.
Time frame: From day 2 through day 15 (up to day 29) of individual participant timeline
Plan to share: Yes — Deidentified individual participant data will be available upon reasonable request to the principal investigator. Access will be granted to researchers who provide a methodologically sound proposal for achieving the aims of the approved proposal. A data access agreement may be required before the data are released.
No publications or documents are linked to this record.
Started Oct 2025 (actual). Primary completion is estimated for Dec 2029, 50 months after the start.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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University of Bordeaux