An interventional study of Single-pulse BreEStim Treatment and Multiple-pulse BreEStim Treatment in Neuropathic Pain, sponsored by The University of Texas Health Science Center, Houston. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-20.
Sponsored by The University of Texas Health Science Center, Houston · Not applicable, Interventional, and Treatment
The overall goal is to evaluate the effectiveness of different stimulation protocol of a novel intervention - Breathing-controlled electrical stimulation (BreEStim) in managing neuropathic pain after spinal cord injury (SCI).
1,303 studies on the registry are indexed under Neuralgia; 261 are open to participants now.
This study's planned enrollment of 32 is below the median of 52 across 986 interventional studies indexed under Neuralgia.
Browse Neuralgia studies →The University of Texas Health Science Center, Houston is the lead sponsor of 897 studies on the registry; 214 are open to participants now.
Of its 173 completed or terminated interventional studies of FDA-regulated products, 142 (82%) have results posted.
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Inclusion Criteria (SCI subjects):
Exclusion Criteria (SCI subjects):
Inclusion criteria (healthy subjects):
Exclusion criteria (healthy subjects):
Device: Single-pulse BreEStim Treatment · Device: Multiple-pulse BreEStim Treatment
Device: Single-pulse BreEStim Treatment · Device: Multiple-pulse BreEStim Treatment
During the Single-pulse BreEStim Treatment session, participants will remain relaxed while breathing is monitored using a nasal cannula. Surface electrodes will be placed over the median nerve at the wrist or another selected peripheral nerve. A single-pulse electrical stimulation will be synchronized with voluntary breathing and delivered at an individually tolerated intensity for approximately 30 minutes.
During the Multiple-pulse BreEStim Treatment session, participants will remain relaxed while breathing is monitored using a nasal cannula. Surface electrodes will be placed over the median nerve at the wrist or another selected peripheral nerve. Multiple-pulse electrical stimulation will be synchronized with voluntary breathing and delivered at an individually tolerated intensity for approximately 30 minutes.
Change in Pain Level as Measured by the Visual Analog Scale (VAS).
VAS scores are recorded from 0 to 10 with 0 being "no pain" and 10 being "worst pain", a higher score indicating a higher level of pain. Change is reported as \[(VAS score at baseline) - (VAS Score 10 minutes after intervention)\] - a positive value indicates that the score (and pain level) decreased. Mean VAS difference will be compared.
Time frame: Baseline, 10-15 minutes after intervention
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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The University of Texas Health Science Center, Houston →