An interventional study of GPB Group : This group will receive ultrasound-guided Gastrocnemius plane block with 30 mL bupivacaine (0.25%) and SAB in Gastrocnemius, Ankle Surgery and Foot Surgery, sponsored by Cairo University. Recruiting at 1 site in Egypt. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-10-16.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
The study aim is to evaluate the efficacy of the gastrocnemius plane block (GPB) in providing postoperative analgesia for patients undergoing foot and ankle surgery.
Objectives:
Cairo University is the lead sponsor of 4,909 studies on the registry; 1,445 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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Exclusion Criteria:
GPB Group will receive Gastrocnemius plane block with 30 mL bupivacaine (0.25%)
Drug: GPB Group : This group will receive ultrasound-guided Gastrocnemius plane block with 30 mL bupivacaine (0.25%) · Drug: SAB
Control Group will receive ultrasound-guided Gastrocnemius plane block with 30 mL normal saline .
Drug: GPB Group : This group will receive ultrasound-guided Gastrocnemius plane block with 30 mL bupivacaine (0.25%) · Drug: SAB
o In lateral position, a high frequency US (Siemens ACUSON X300 Ultrasound System) linear probe (8-12 mhz) will be placed in the popliteal fossa facing the operator. Scanning continue towards the foot, and the gastrocnemius will appear. As the scanning progresses towards the caput fibulae, the soleus gradually becomes visible. Once Gastrosoleus Interfascial Plane is identified, a needle advanced by consultant anesthesiologists who had experience in regional anesthesia in a lateral-to-medial direction into the lower surface of the gastrocnemius (between the gastrocnemius and the soleus). Subsequently, 20 mL bupivacaine (0.25%) will be injected to separate the fascias of the two muscles, allowing the local anaesthetic to diffuse around the tibial nerve through the fascial gap. The needle is then withdrawn to the upper surface of the gastrocnemius, and 10 mL bupivacaine (0.25%) will be injected into the upper surface (between gastrocnemius and deep subcutaneous fascia) to block
* Patients will receive SAB using 25g spinal needle in the lateral position with rapid crystalloid co-loading. Fifteen milligrams of hyperbaric bupivacaine will be administered at L3-L4 or at L4-L5 interspace in addition to 25 mcg fentanyl. The dose will be reduced to 10 mg in patients aged above 60 years. * SAB will be considered successful when a bilateral block is confirmed at T12. The block success will be assessed by loss of cold (cold ice) and pain (a 23-gauge needle) sensations. If spinal anaesthesia fails, the patient will receive general anaesthesia and will be excluded from the study.
Time to first postoperative analgesic request
Time to first postoperative analgesic request
Time frame: 24 hours
Visual analogue pain score (VAS)
Visual analogue pain score (VAS) at rest (static), and on movement (dynamic) at 2, 4, 6, 12, 18, and 24 hours postoperatively
Time frame: 24 hours
Postoperative assessment of sensory and motor function
Assessment of sensory block: Sensory block will be assessed using a pinprick test with a blunt 22-gauge needle along dermatomes relevant to the surgery. The degree of sensory loss will be graded as follows: * Grade 0: Normal sensation to pinprick * Grade 1: Decreased but present sensation to pinprick (hypoalgesia) * Grade 2: Complete loss of sensation to pinprick (analgesia)
Time frame: 24 hours
Time to first postoperative analgesic request
Time to first postoperative analgesic request
Time frame: 24 hours
Total morphine requirements
Total morphine requirements 24 hours postoperatively.
Time frame: 24 hours
Time to early mobilization
Time to early mobilization: First bedtime helps to judge the effect of the nerve block
Time frame: 24 hours
Incidence of complications related to the blocks
Incidence of complications related to the blocks as hematoma or Toxicity
Time frame: 24 hours
Incidence of postoperative nausea and vomiting
Incidence of postoperative nausea and vomiting
Time frame: 24 hours
Postoperative assessment of motor function
Assessment of motor block: using the Modified Bromage score, which will be evaluated to assess the motor block as follows: * Bromage 0: full flexion of the knee and feet. * Bromage 1: just able to move the knee * Bromage 2: able to move the feet. * Bromage 3: unable to move the knees and feet
Time frame: 24 hours
Plan to share: Undecided
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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