An interventional study of predominantly tissue-repositioning thread lifting and predominantly tissue-support thread-lifting in Nasolabial Fold, sponsored by Beijing Tsinghua Chang Gung Hospital. Completed at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-10-16.
Sponsored by Beijing Tsinghua Chang Gung Hospital · Not applicable, Interventional, and Treatment
This randomized clinical trial compares two minimally invasive thread-lifting procedures for improving moderate-to-severe nasolabial folds, the lines that run from the sides of the nose toward the corners of the mouth. Both procedures use absorbable threads placed under the skin, but they differ in their main treatment approach. One procedure is designed primarily to lift and reposition sagging facial tissues, whereas the other is designed primarily to provide local support and added volume beneath and around the folds.
Approximately 180 adults with moderate-to-severe nasolabial folds will be randomly assigned to one of the two treatment groups. An independent evaluator who does not know the treatment assignment will assess changes in the nasolabial folds during follow-up. The main purpose of the study is to compare the effectiveness of the two procedures 7 months after treatment. The study will also assess early improvement, participants' and evaluators' overall impressions of the results, and treatment-related adverse events and safety.
Beijing Tsinghua Chang Gung Hospital is the lead sponsor of 102 studies on the registry; 52 are open to participants now.
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Healthy Chinese female or male between 18 and 65 years.
Exclusion Criteria:
·With a hypersensitive constitution.
Participants received a predominantly tissue-repositioning and multi-plane tissue-lifting thread-lifting protocol for correction of moderate-to-severe nasolabial folds.
Procedure: predominantly tissue-repositioning thread lifting
A predominantly tissue-support and multiregional volumization thread-lifting protocol for correction of moderate-to-severe nasolabial folds.
Procedure: predominantly tissue-support thread-lifting
A predominantly tissue-repositioning and multi-plane tissue-lifting thread-lifting protocol for correction of moderate-to-severe nasolabial folds.
A predominantly tissue-support and multiregional volumization thread-lifting protocol for correction of moderate-to-severe nasolabial folds.
WSRS effective rate (ER) for NLF correction at 7 months post-operation
The ER was calculated as the percentage of effective responses among subjects in the relevant analysis population.
Time frame: 7 months post-operation
ERs of NLF correction
The ERs of NLF correction immediately after surgery (V2) and at 14 days (V3), 1 month (V4), and 3 months (V5) postoperatively.
Time frame: Immediately after surgery (V2) and at 14 days (V3), 1 month (V4), and 3 months (V5) postoperatively
Percentage improvement in WSRS scores
Percentage improvement in WSRS scores (%) was calculated as \[(baseline WSRS score - post-operation WSRS score) / baseline WSRS score\] × 100%
Time frame: Immediately after surgery (V2), and at 14 days (V3), 1 month (V4), 3 months (V5), and 7 months (V6) postoperatively.
The mean GAIS scores
The mean GAIS scores at all follow-up visits (V2-V6). The GAIS was a 5-point scale (1 = very much improved; 5 = worse), assessed independently by the subjects and independent evaluators.
Time frame: Immediately after surgery (V2), and at 14 days (V3), 1 month (V4), 3 months (V5), and 7 months (V6) postoperatively.
Plan to share: No
No publications or documents are linked to this record.
Ran from Jun 2022 to primary completion in Nov 2023, 16 months.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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