An interventional study of Long-acting absorbable mesh in Incisional Hernia of Anterior Abdominal Wall, sponsored by Corewell Health West. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-13.
Sponsored by Corewell Health West · Not applicable, Interventional, and Prevention
This prospective study will evaluate whether placement of long-acting absorbable Phasix mesh during loop ileostomy closure reduces the development of an incisional hernia at the ileostomy closure site in patients with a BMI greater than 25. Participants will undergo mesh-reinforced closure and will be followed for two years after surgery. The primary outcome is development of an incisional hernia at the ileostomy closure site, confirmed by CT imaging at two years.
226 studies on the registry are indexed under Incisional Hernia; 53 are open to participants now.
This study's planned enrollment of 65 is below the median of 107 across 142 interventional studies indexed under Incisional Hernia.
Browse Incisional Hernia studies →Corewell Health West is the lead sponsor of 16 studies on the registry; 9 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants undergoing loop ileostomy closure will receive prophylactic long-acting absorbable Phasix mesh reinforcement at the ileostomy closure site.
Device: Long-acting absorbable mesh
Lon-acting absorbable Phasix mesh is placed in the retro-rectus space during loop ileostomy closure to reinforce the closure site. The posterior rectus sheath is closed prior to mesh placement, and the mesh is not fixated to surrounding tissue. If the posterior rectus sheath is not intact or cannot be closed, mesh-reinforced closure is not performed and standard primary closure with suture is used.
Incisional Hernia at the Loop Ileostomy Closure Site
Development of an incisional hernia at the loop ileostomy closure site, confirmed by CT imaging.
Time frame: 2 years after loop ileostomy closure
Operative Time
Duration of the loop ileostomy closure procedure
Time frame: During surgery
Blood Transfusions
Occurrence of blood transfusion associated with the loop ileostomy closure procedure.
Time frame: Perioperative/Periprocedural
Surgical Site Infection
Occurrence of surgical site infection following loop ileostomy closure.
Time frame: Within 30 days after surgery
Postoperative Morbidity
Postoperative mobidity assessed using the Clavien-Dindo Classification.
Time frame: Through 6 weeks after surgery
Postoperative Mortality
Occurrence of death following loop ileostomy closure.
Time frame: Through 6 weeks after surgery
Hospital Length of Stay
Number of das hospitalized following loop ileostomy closure.
Time frame: Up to 6 weeks after surgery
ICU Length of Stay
Number of days spent in the intesive care unit following loop ileostomy closure, if applicable.
Time frame: Up to 6 weeks after surgery
Reoperation
Occurrence of reoperation following loop ileostomy closure.
Time frame: Through 6 weeks after surgery
Hospital Readmission
Occurence of hospital readmission folloing loop ileostomy closure.
Time frame: 30, 60, and 90 days after surgery
Seroma
Occurence of seroma associated with the mesh-reinforced loop ileostomy closure site.
Time frame: Through 6 weeks after surgery
Hematoma
Occurrence of hematoma associated with the mesh-reinforced loop ileostomy closure site.
Time frame: Through 6 weeks after surgery
Mesh-Related Infection
Occurence of infection associated with the mesh-reinforced loop ileostomy closure site.
Time frame: Through 6 weeks after surgery
Mesh-Related Reoperation
Occurence of reoperation related to the mesh-reinforced loop ileostomy closure site.
Time frame: Through 6 weeks after surgery
Health-Related Quality of Life (SF-36)
Self-reported health-related quality of life assessed using the Short Form-36 (SF-36) questionnaire.
Time frame: Preoperative visit, 6 weeks after surgery, and 2 years after surgery
Activity Level (Activities Assessent Scale)
Self-reported activity level assessed using the Activities Assessment Scale (AAS) questionnaire.
Time frame: Preoperative visit, 6 weeks after surgery, and 2 years after surgery
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Oct 2026; primary completion for Oct 2027, 12 months later.
Of 64 non-industry interventional studies with no phase under Incisional Hernia, half reached primary completion within 43 months of starting (the median), counting those still running; a quarter within 18 and three quarters within 60. This study's planned 12 months is below that.
Counting every sponsor, half of 71 studies reached it within 43 months; a quarter within 23 and three quarters within 76.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Corewell Health West