An observational study in Influenza, COVID-19 and Vaccination Willingness, sponsored by George Washington University. Not yet recruiting at 2 sites in United States. Open to participants aged 18 Years to 89 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-13.
Sponsored by George Washington University · Observational
This study addresses a critical evidence gap relevant to implementation strategies for combination vaccines in health care settings. This study will specifically investigate healthcare worker (HCWs) attitudes around and willingness to receive combination influenza/COVID-19 vaccines. Findings will identify determinants of hesitancy and acceptance among HCWs and support effective rollout strategies and communication approaches. Cross-sectional surveys and qualitative interviews will be conducted with healthcare workers to characterize HCW willingness to be vaccinated and to identify demographic, attitudinal, and structural predictors of vaccination.
This study uses a sequential explanatory mixed-methods design. The first phase utilizes a cross-sectional, multi-site electronic survey. The quantitative survey will characterize willingness of approximately 550 HCWs to receive a combination influenza/COVID-19 vaccine and to identify demographic, attitudinal, and structural predictors of vaccination. Participants will complete a one-time REDCap survey (approximately 20-30 minutes).
In the second phase, a subset of 10-20 HCWs will be invited to participate in qualitative interviews that will be used to interpret and elaborate on quantitative findings. Specifically, the qualitative analysis allows for exploration of the nuanced rationale behind reported willingness to vaccinate, gives additional context to latent constructs identified in factor analysis, and identifies communication preferences that are not adequately captured by closed-ended questions. Integration will occur at the interpretation stage: quantitative results will inform purposive sampling for the qualitative phase, and qualitative themes will be used to contextualize and explain patterns observed in the quantitative analysis. A joint display table will be used in reporting to show how qualitative findings confirm, extend, or challenge quantitative results.
2,264 studies on the registry are indexed under Influenza, Human; 173 are open to participants now.
This study's planned enrollment of 550 is above the median of 300 across 313 observational studies indexed under Influenza, Human.
Browse Influenza, Human studies →George Washington University is the lead sponsor of 191 studies on the registry; 34 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 11 (85%) have results posted.
Counted across the registry records on this site, refreshed daily.
Healthcare workers who are eligible for seasonal influenza vaccination, encompassing both clinical and non-clinical positions (physicians, advanced practice providers, nurses, allied health professionals, administrative and support staff, trainees, and students). We are targeting enrollment of 275 participants per site (George Washington University and Children's National Hospital), for a study-wide total of 550.
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Exclusion Criteria:
One-time RedCAP electronic survey on the willingness of healthcare workers to receive a combination influenza/COVID-19 vaccine and factors that might influence this decision.
Proportion of health care workers (HCWs) who indicate that they would "definitely" or "probably" receive a combination influenza and COVID-19 vaccine.
Time frame: Day 1
Proportion of HCWs willing to receive standalone seasonal influenza vaccines.
Time frame: Day 1
Proportion of HCWs willing to receive standalone COVID-19 vaccines, also stratified by COVID-19 vaccine platform (mRNA vs. protein-based).
Time frame: Day 1
Determinants of willingness to receive combination influenza and COVID-19 vaccines as assessed by multivariable logistic regression.
Adjusted odds ratios (aOR) for demographic, occupational, behavioral, attitudinal, and emotional predictors associated with vaccination willingness, measured using responses from the REDCap electronic survey.
Time frame: Day 1
Categorization of attitudes toward co-administration compared with true combination vaccine formulations as assessed by semi-structured qualitative interviews.
Qualitative thematic analysis of healthcare worker attitudes and preferences recorded using a semi-structured qualitative interview guide.
Time frame: Day 1 through completion of the qualitative surveys, an average of 1 month.
Participant ranking of messaging options associated with willingness to receive combination vaccines as assessed by REDCap survey.
Mean ranking scores of communication messaging options measured via ordinal ranking items in the REDCap electronic survey.
Time frame: Day 1 through completion of the qualitative surveys, an average of 1 month.
Proportion of participants in different thematic categories regarding concerns, motivations, and preferred communication strategies as assessed by qualitative thematic analysis.
Identified qualitative themes and sub-themes synthesized using qualitative thematic analysis from REDCap survey free-text fields and semi-structured interview transcripts.
Time frame: Day 1 through completion of the qualitative surveys, an average of 1 month.
Proportion of participants in different thematic categories associated with willingness to receive combination vaccines as assessed by semi-structured qualitative interviews.
Qualitative themes identified through inductive thematic analysis of semi-structured interview transcripts.
Time frame: Day 1 through completion of the qualitative surveys, an average of 1 month.
Plan to share: Undecided
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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