An interventional study of Exercise and Exercise in Healthy Adult Male and Healthy Adult Females, sponsored by University of British Columbia. Not yet recruiting at 1 site in Canada. Open to participants aged 19 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-08.
Sponsored by University of British Columbia · Not applicable, Interventional, and Other
This study will compare mitochondrial function and leg blood flow during exercise in healthy endurance-trained females and males aged 19-35.
This study will compare mitochondrial function and leg blood flow during exercise in healthy endurance-trained females and males aged 19-35. Participants will complete five laboratory visits over 2-3 weeks, including cycling and single-leg knee extension exercise tests, a dual-energy X-ray absorptiometry (DXA) body composition scan, one resting thigh muscle biopsy, ultrasound blood-flow measurements, muscle oxygen and activity measurements, intramuscular pressure measurement, OMNI perceived exertion ratings, and a finger-prick hemoglobin sample. The study will examine whether sex-related differences in muscle energy use, muscle torque, and muscle pressure help explain blood-flow delivery during exercise.
University of British Columbia is the lead sponsor of 1,310 studies on the registry; 253 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 1 (17%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
currently use cigarettes, vaping products, or other nicotine products, or have used them in the past 2 years;
Endurance Trained Healthy Males
Other: Exercise
Endurance Trained Healthy Females
Other: Exercise
Exercise - Men
Exercise - Females
Isolated mitochondria maximal state 3 respiration (pmols O2/microgram) measured via an ouroborous oxygraph (mitochondrial respirometry)
This measure quantifies the maximal rate of oxygen consumption (picomoles O2/ micogram of mitochondrial protein) when ADP, Malate, Succinate, Pyruvate and Glutamate have all been addded to the chamber.
Time frame: Baseline
Maximal state 3 respiration in permeabilized Fibers (pmols O2/mg) measured via an ouroborous oxygraph (mitochondrial respirometry)
This measure quantifies the maximal rate of oxygen consumption (picomoles O2/ milligram of muscle tissue) when ADP, Malate, Succinate, Pyruvate and Glutamate have all been added to the chamber.
Time frame: Baseline
Fiber type 1 specific maximal state 3 respiration (pmols O2/mg) measured via an ouroborous oxygraph (mitochondrial respirometry)
This measure quantifies the maximal rate of oxygen consumption (picomoles O2/ micogram of mitochondrial protein) when ADP, Malate, Succinate, Pyruvate and Glutamate have all been added to the chamber.
Time frame: Baseline
Fiber type 2 specific maximal state 3 respiration (pmols O2/mg) measured via an ouroborous oxygraph (mitochondrial respirometry)
This measure quantifies the maximal rate of oxygen consumption (picomoles O2/ micogram of mitochondrial protein) when ADP, Malate, Succinate, Pyruvate and Glutamate have all been addded to the chamber.
Time frame: Baseline
Plan to share: Undecided — Undecided
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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University of British Columbia