An interventional study of Thigh Reduction Cream and Placebo Cream in Thigh Cellulite, sponsored by Frank Greenway. Not yet recruiting. Open to female participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-10-07.
Sponsored by Frank Greenway · Not applicable, Interventional, and Treatment
this study tests the hypothesis that naringenin, beta carotene and menthol cream when applied to one thigh and a placebo cream to the other twice a day will result in greater loss of girth, smoother appearance of the skin and a greater increase in lipolysis on the treated vs. the placebo cream over 8 weeks
10 women 18 to 50 years of age who are overweight or obese and desire smaller and smoother thighs will have size assessed by measuring girth and smoothness assessed by photographs at baseline and at the end of the study at week 8. Lipolysis will be assessed by microdialysis.
71 studies on the registry are indexed under Cellulite; 3 are open to participants now.
This study's planned enrollment of 10 is below the median of 34 across 65 interventional studies indexed under Cellulite.
Browse Cellulite studies →Frank Greenway is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria: 25-35 kg/m2, Stable weight +/- 3kg in last 2 months, self-reported cellulite -
Exclusion Criteria: women of child bearing potential who do not agree to use an effective method during the trial, lymphedema, skin problems precluding use of a cream, allergy to citrus fruit, carrots mint, skin disease of the thighs like psoriasis, eczema, contact dermatitis or other skin disease of the thighs, and vulnerable populations like children, prisoners, pregnant women or people unable to give consent.
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Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
naringenin, beta carotene with menthol cream
Other: Thigh Reduction Cream
Placebo cream used twice a day on the control thigh
Other: Placebo Cream
naringenn, beta carotene with menthol cream
Placebo cream added twice a day on control thigh
Thigh girth
Difference in girth between treated and placebo thigh
Time frame: Cream application twice a day for 8 weeks
No study locations are listed for this record.
Plan to share: Yes — Results will be available for review by scientists needing that information from the Nutrition Obesity Research Center repository at Pennington Biomedical Research Center
Supporting information: Study protocol, Informed consent form, Clinical study report
Time frame: Estimated to be July 1, 2027
Access criteria: Scientists have need for the individual patient data will be able to obtain it trough the Nutrition Obesity Research Center at Pennington Biomedical Research Center.
Data sharing details ↗ · www.bing.com
Start is estimated for Jan 2027; primary completion for Jul 2027, 6 months later.
Of 20 interventional studies with no phase under Cellulite, half reached primary completion within 12 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 14. This study's planned 6 months is below that.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Frank Greenway